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1.

Controlling the anaphylatoxin C5a in diseases requires a specifically targeted inhibition.

Riedemann, Niels C; Habel, Maria; Ziereisen, Jana; Hermann, Marlen; Schneider, Conny; Wehling, Cyrill; Kirschfink, Michael; Kentouche, Karim; Guo, Renfeng.

Clin Immunol ; 180: 25-32, 2017 07.

Artículo en Inglés | MEDLINE | ID: mdl-28366510

2.

A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a.

Hünniger, Kerstin; Bieber, Kristin; Martin, Ronny; Lehnert, Teresa; Figge, Marc Thilo; Löffler, Jürgen; Guo, Ren-Feng; Riedemann, Niels C; Kurzai, Oliver.

J Immunol ; 194(3): 1199-210, 2015 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-25539819

3.

Treatment with anti-C5a antibody improves the outcome of H7N9 virus infection in African green monkeys.

Sun, Shihui; Zhao, Guangyu; Liu, Chenfeng; Fan, Wei; Zhou, Xiaojun; Zeng, Lin; Guo, Yan; Kou, Zhihua; Yu, Hong; Li, Junfeng; Wang, Renxi; Li, Yan; Schneider, Conny; Habel, Maria; Riedemann, Niels C; Du, Lanying; Jiang, Shibo; Guo, Renfeng; Zhou, Yusen.

Clin Infect Dis ; 60(4): 586-95, 2015 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-25433014

4.

End-of-life care in the intensive care unit: a patient-based questionnaire of intensive care unit staff perception and relatives' psychological response.

Hartog, Christiane S; Schwarzkopf, Daniel; Riedemann, Niels C; Pfeifer, Ruediger; Guenther, Albrecht; Egerland, Kati; Sprung, Charles L; Hoyer, Heike; Gensichen, Jochen; Reinhart, Konrad.

Palliat Med ; 29(4): 336-45, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25634628

5.

New approaches to sepsis: molecular diagnostics and biomarkers.

Reinhart, Konrad; Bauer, Michael; Riedemann, Niels C; Hartog, Christiane S.

Clin Microbiol Rev ; 25(4): 609-34, 2012 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-23034322

6.

Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*.

Bayer, Ole; Schwarzkopf, Daniel; Doenst, Torsten; Cook, Deborah; Kabisch, Bjoern; Schelenz, Christoph; Bauer, Michael; Riedemann, Niels C; Sakr, Yasser; Kohl, Matthias; Reinhart, Konrad; Hartog, Christiane S.

Crit Care Med ; 41(11): 2532-42, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-23978813

7.

Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis.

Dahlke, Katja; Wrann, Christiane D; Sommerfeld, Oliver; Sossdorf, Maik; Recknagel, Peter; Sachse, Svea; Winter, Sebastian W; Klos, Andreas; Stahl, Gregory L; Ma, Yuanyuan Xu; Claus, Ralf A; Reinhart, Konrad; Bauer, Michael; Riedemann, Niels C.

J Immunol ; 186(5): 3066-75, 2011 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-21263075

8.

Pharmacokinetic analysis of vilobelimab, anaphylatoxin C5a and antidrug antibodies in PANAMO: a phase 3 study in critically ill, invasively mechanically ventilated COVID-19 patients.

Lim, Endry H T; Vlaar, Alexander P J; de Bruin, Sanne; Rückinger, Simon; Thielert, Claus; Habel, Maria; Guo, Renfeng; Burnett, Bruce P; Dickinson, James; Brouwer, Matthijs C; Riedemann, Niels C; van de Beek, Diederik.

Intensive Care Med Exp ; 11(1): 37, 2023 Jun 19.

Artículo en Inglés | MEDLINE | ID: mdl-37332066

9.

Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis.

Recknagel, Peter; Gonnert, Falk A; Westermann, Martin; Lambeck, Sandro; Lupp, Amelie; Rudiger, Alain; Dyson, Alex; Carré, Jane E; Kortgen, Andreas; Krafft, Christoph; Popp, Jürgen; Sponholz, Christoph; Fuhrmann, Valentin; Hilger, Ingrid; Claus, Ralf A; Riedemann, Niels C; Wetzker, Reinhard; Singer, Mervyn; Trauner, Michael; Bauer, Michael.

PLoS Med ; 9(11): e1001338, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-23152722

10.

The anti-C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID-19.

Vlaar, Alexander P J; Lim, Endry H T; de Bruin, Sanne; Rückinger, Simon; Pilz, Korinna; Brouwer, Matthijs C; Guo, Ren-Feng; Heunks, Leo M A; Busch, Matthias H; van Paassen, Pieter; Riedemann, Niels C; van de Beek, Diederik.

Clin Transl Sci ; 15(4): 854-858, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35029045

11.

Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

Vlaar, Alexander P J; Witzenrath, Martin; van Paassen, Pieter; Heunks, Leo M A; Mourvillier, Bruno; de Bruin, Sanne; Lim, Endry H T; Brouwer, Matthijs C; Tuinman, Pieter R; Saraiva, José F K; Marx, Gernot; Lobo, Suzana M; Boldo, Rodrigo; Simon-Campos, Jesus A; Cornet, Alexander D; Grebenyuk, Anastasia; Engelbrecht, Johannes M; Mukansi, Murimisi; Jorens, Philippe G; Zerbib, Robert; Rückinger, Simon; Pilz, Korinna; Guo, Renfeng; van de Beek, Diederik; Riedemann, Niels C.

Lancet Respir Med ; 10(12): 1137-1146, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-36087611

12.

Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison.

Bayer, Ole; Reinhart, Konrad; Sakr, Yasser; Kabisch, Bjoern; Kohl, Matthias; Riedemann, Niels C; Bauer, Michael; Settmacher, Utz; Hekmat, Khosro; Hartog, Christiane S.

Crit Care Med ; 39(6): 1335-42, 2011 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-21358396

13.

Novel strategies for the treatment of sepsis.

Riedemann, Niels C; Guo, Ren-Feng; Ward, Peter A.

Nat Med ; 9(5): 517-24, 2003 May.

Artículo en Inglés | MEDLINE | ID: mdl-12724763

14.

The late phase of sepsis is characterized by an increased microbiological burden and death rate.

Otto, Gordon P; Sossdorf, Maik; Claus, Ralf A; Rödel, Jürgen; Menge, Katja; Reinhart, Konrad; Bauer, Michael; Riedemann, Niels C.

Crit Care ; 15(4): R183, 2011 Jul 28.

Artículo en Inglés | MEDLINE | ID: mdl-21798063

15.

Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis.

Wang, Liyan; Han, Gencheng; Wang, Renxi; Chen, Guojiang; Xu, Ruonan; Xiao, He; Li, Xia; Geng, Shaoxia; Li, Yurong; Li, Xinying; Wang, Jianan; Feng, Jiannan; Riedemann, Niels C; Guo, Renfeng; Shen, Beifen; Li, Yan.

Clin Immunol ; 137(1): 157-65, 2010 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-20591742

16.

Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial.

Vlaar, Alexander P J; de Bruin, Sanne; Busch, Matthias; Timmermans, Sjoerd A M E G; van Zeggeren, Ingeborg E; Koning, Rutger; Ter Horst, Liora; Bulle, Esther B; van Baarle, Frank E H P; van de Poll, Marcel C G; Kemper, E Marleen; van der Horst, Iwan C C; Schultz, Marcus J; Horn, Janneke; Paulus, Frederique; Bos, Lieuwe D; Wiersinga, W Joost; Witzenrath, Martin; Rueckinger, Simon; Pilz, Korinna; Brouwer, Matthijs C; Guo, Ren-Feng; Heunks, Leo; van Paassen, Pieter; Riedemann, Niels C; van de Beek, Diederik.

Lancet Rheumatol ; 2(12): e764-e773, 2020 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-33015643

17.

The enigma of sepsis.

Riedemann, Niels C; Guo, Ren-Feng; Ward, Peter A.

J Clin Invest ; 112(4): 460-7, 2003 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-12925683

18.

Increased C5a receptor expression in sepsis.

Riedemann, Niels C; Guo, Ren-Feng; Neff, Thomas A; Laudes, Ines J; Keller, Katie A; Sarma, Vidya J; Markiewski, Maciej M; Mastellos, Dimitrios; Strey, Christoph W; Pierson, Carl L; Lambris, John D; Zetoune, Firas S; Ward, Peter A.

J Clin Invest ; 110(1): 101-8, 2002 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-12093893

19.

Evidence for a functional role of the second C5a receptor C5L2.

Gao, Hongwei; Neff, Thomas A; Guo, Ren-Feng; Speyer, Cecilia L; Sarma, J Vidya; Tomlins, Scott; Man, Yunfang; Riedemann, Niels C; Hoesel, L Marco; Younkin, Ellen; Zetoune, Firas S; Ward, Peter A.

FASEB J ; 19(8): 1003-5, 2005 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-15784721

20.

Oxidized lipid protects against sepsis.

Riedemann, Niels C; Ward, Peter A.

Nat Med ; 8(10): 1084-5, 2002 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-12357242

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