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1.

FuSe: a tool to move RNA-Seq analyses from chromosomal/gene loci to functional grouping of mRNA transcripts.

Gupta, Rajinder; Schrooders, Yannick; Verheijen, Marcha; Roth, Adrian; Kleinjans, Jos; Caiment, Florian.

Bioinformatics ; 37(3): 375-381, 2021 04 20.

Artículo en Inglés | MEDLINE | ID: mdl-32814975

2.

Translational precision medicine: an industry perspective.

Hartl, Dominik; de Luca, Valeria; Kostikova, Anna; Laramie, Jason; Kennedy, Scott; Ferrero, Enrico; Siegel, Richard; Fink, Martin; Ahmed, Sohail; Millholland, John; Schuhmacher, Alexander; Hinder, Markus; Piali, Luca; Roth, Adrian.

J Transl Med ; 19(1): 245, 2021 06 05.

Artículo en Inglés | MEDLINE | ID: mdl-34090480

3.

Snapshot 3D reconstruction of liquid surfaces.

Roth, Adrian; Kristensson, Elias; Berrocal, Edouard.

Opt Express ; 28(12): 17906-17922, 2020 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-32679993

4.

Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.

Schadt, Simone; Hauri, Simon; Lopes, Filipe; Edelmann, Martin R; Staack, Roland F; Villaseñor, Roberto; Kettenberger, Hubert; Roth, Adrian B; Schuler, Franz; Richter, Wolfgang F; Funk, Christoph.

Drug Metab Dispos ; 47(12): 1443-1456, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31748266

5.

Current limitations and future opportunities for prediction of DILI from in vitro.

Funk, Christoph; Roth, Adrian.

Arch Toxicol ; 91(1): 131-142, 2017 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-27766365

6.

Temporal Patterns of Novel Circulating Biomarkers in IL-2-mediated Vascular Injury in the Rat.

Keirstead, Natalie D; Bertinetti-Lapatki, Cristina; Knapp, Denise; Albassam, Mudher; Hughes, Valerie; Hong, Feng; Roth, Adrian B; Mikaelian, Igor.

Toxicol Pathol ; 43(7): 984-94, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-26353978

7.

Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis.

Benay, Stephan; Meille, Christophe; Kustermann, Stefan; Walter, Isabelle; Walz, Antje; Gonsard, P Alexis; Pietilae, Elina; Kratochwil, Nicole; Iliadis, Athanassios; Roth, Adrian; Lave, Thierry.

J Pharmacokinet Pharmacodyn ; 42(3): 275-85, 2015 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-25822652

8.

Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems.

Parvatam, Surat; Pamies, David; Pistollato, Francesca; Beken, Sonja; Mariappan, Indumathi; Roth, Adrian; Piergiovanni, Monica; G C Maisonneuve, Benoît; Ewart, Lorna; Majumder, Abhijit; Dandekar, Prajakta; Date, Rahul; Mahadik, Kasturi; Thiyagarajan, Saravanan; Coecke, Sandra.

Stem Cell Reports ; 19(1): 37-40, 2024 01 09.

Artículo en Inglés | MEDLINE | ID: mdl-38134927

9.

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.

Kostadinova, Radina; Boess, Franziska; Applegate, Dawn; Suter, Laura; Weiser, Thomas; Singer, Thomas; Naughton, Brian; Roth, Adrian.

Toxicol Appl Pharmacol ; 268(1): 1-16, 2013 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-23352505

10.

A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.

Kuepfer, Lars; Clayton, Olivia; Thiel, Christoph; Cordes, Henrik; Nudischer, Ramona; Blank, Lars M; Baier, Vanessa; Heymans, Stephane; Caiment, Florian; Roth, Adrian; Fluri, David A; Kelm, Jens M; Castell, José; Selevsek, Nathalie; Schlapbach, Ralph; Keun, Hector; Hynes, James; Sarkans, Ugis; Gmuender, Hans; Herwig, Ralf; Niederer, Steven; Schuchhardt, Johannes; Segall, Matthew; Kleinjans, Jos.

Arch Toxicol ; 92(1): 553-555, 2018 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-28852801

11.

The evolving role of investigative toxicology in the pharmaceutical industry.

Pognan, Francois; Beilmann, Mario; Boonen, Harrie C M; Czich, Andreas; Dear, Gordon; Hewitt, Philip; Mow, Tomas; Oinonen, Teija; Roth, Adrian; Steger-Hartmann, Thomas; Valentin, Jean-Pierre; Van Goethem, Freddy; Weaver, Richard J; Newham, Peter.

Nat Rev Drug Discov ; 22(4): 317-335, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-36781957

12.

New approach methodologies in human regulatory toxicology - Not if, but how and when!

Schmeisser, Sebastian; Miccoli, Andrea; von Bergen, Martin; Berggren, Elisabet; Braeuning, Albert; Busch, Wibke; Desaintes, Christian; Gourmelon, Anne; Grafström, Roland; Harrill, Joshua; Hartung, Thomas; Herzler, Matthias; Kass, George E N; Kleinstreuer, Nicole; Leist, Marcel; Luijten, Mirjam; Marx-Stoelting, Philip; Poetz, Oliver; van Ravenzwaay, Bennard; Roggeband, Rob; Rogiers, Vera; Roth, Adrian; Sanders, Pascal; Thomas, Russell S; Marie Vinggaard, Anne; Vinken, Mathieu; van de Water, Bob; Luch, Andreas; Tralau, Tewes.

Environ Int ; 178: 108082, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37422975

13.

High-speed videography of transparent media using illumination-based multiplexed schlieren.

Ek, Simon; Kornienko, Vassily; Roth, Adrian; Berrocal, Edouard; Kristensson, Elias.

Sci Rep ; 12(1): 19018, 2022 Nov 08.

Artículo en Inglés | MEDLINE | ID: mdl-36347904

14.

Gene expression-based in vivo and in vitro prediction of liver toxicity allows compound selection at an early stage of drug development.

Roth, Adrian; Boess, Franziska; Landes, Christian; Steiner, Guido; Freichel, Christian; Plancher, Jean-Marc; Raab, Susanne; de Vera Mudry, Cristina; Weiser, Thomas; Suter, Laura.

J Biochem Mol Toxicol ; 25(3): 183-94, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-21671310

15.

Human microphysiological systems for drug development.

Roth, Adrian.

Science ; 373(6561): 1304-1306, 2021 Sep 17.

Artículo en Inglés | MEDLINE | ID: mdl-34529479

16.

Challenging the pipeline.

Loskill, Peter; Hardwick, Rhiannon N; Roth, Adrian.

Stem Cell Reports ; 16(9): 2033-2037, 2021 09 14.

Artículo en Inglés | MEDLINE | ID: mdl-34525380

17.

A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.

Baier, Vanessa; Clayton, Olivia; Nudischer, Ramona; Cordes, Henrik; Schneider, Annika R P; Thiel, Christoph; Wittenberger, Timo; Moritz, Wolfgang; Blank, Lars M; Neumann, Ulf P; Trautwein, Christian; Kelm, Jens; Schrooders, Yannick; Caiment, Florian; Gmuender, Hans; Roth, Adrian; Castell, José V; Kleinjans, Jos; Kuepfer, Lars.

Clin Pharmacol Ther ; 110(5): 1293-1301, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34462909

18.

Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies.

Vormann, Marianne K; Vriend, Jelle; Lanz, Henriëtte L; Gijzen, Linda; van den Heuvel, Angelique; Hutter, Simon; Joore, Jos; Trietsch, Sebastiaan J; Stuut, Christiaan; Nieskens, Tom T G; Peters, Janny G P; Ramp, Daniela; Caj, Michaela; Russel, Frans G M; Jacobsen, Björn; Roth, Adrian; Lu, Shuyan; Polli, Joseph W; Naidoo, Anita A; Vulto, Paul; Masereeuw, Rosalinde; Wilmer, Martijn J; Suter-Dick, Laura.

J Pharm Sci ; 110(4): 1601-1614, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33545187

19.

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.

Kerns, S Jordan; Belgur, Chaitra; Petropolis, Debora; Kanellias, Marianne; Barrile, Riccardo; Sam, Johannes; Weinzierl, Tina; Fauti, Tanja; Freimoser-Grundschober, Anne; Eckmann, Jan; Hage, Carina; Geiger, Martina; Ng, Patrick Ray; Tien-Street, William; Manatakis, Dimitris V; Micallef, Virginie; Gerard, Regine; Bscheider, Michael; Breous-Nystrom, Ekaterina; Schneider, Anneliese; Giusti, Anna Maria; Bertinetti-Lapatki, Cristina; Grant, Heather Shannon; Roth, Adrian B; Hamilton, Geraldine A; Singer, Thomas; Karalis, Katia; Moisan, Annie; Bruenker, Peter; Klein, Christian; Bacac, Marina; Gjorevski, Nikolce; Cabon, Lauriane.

Elife ; 102021 08 11.

Artículo en Inglés | MEDLINE | ID: mdl-34378534

20.

Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity.

Nudischer, Ramona; Renggli, Kasper; Hierlemann, Andreas; Roth, Adrian B; Bertinetti-Lapatki, Cristina.

PLoS One ; 15(7): e0235745, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-32645073

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