Detalles de la búsqueda
1.
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
J Am Chem Soc
; 141(22): 8951-8968, 2019 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31060360
2.
Automated design of ligands to polypharmacological profiles.
Nature
; 492(7428): 215-20, 2012 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23235874
3.
Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification.
Anal Chem
; 88(19): 9510-9517, 2016 10 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27583774
4.
The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.
Brain Res Bull
; 202: 110748, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37657612
5.
The structural basis of fatty acid elongation by the ELOVL elongases.
Nat Struct Mol Biol
; 28(6): 512-520, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34117479
6.
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
Bioorg Med Chem
; 18(14): 5056-62, 2010 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20598892
7.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur J Med Chem
; 177: 316-337, 2019 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31158747
8.
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates.
FEBS J
; 274(1): 275-86, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17222187
9.
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.
J Med Chem
; 60(6): 2287-2304, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28182408
10.
Assessing histone demethylase inhibitors in cells: lessons learned.
Epigenetics Chromatin
; 10: 9, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28265301
11.
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Cell Chem Biol
; 24(3): 371-380, 2017 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28262558
12.
Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.
J Med Chem
; 49(14): 4183-95, 2006 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-16821778
13.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J Med Chem
; 59(4): 1388-409, 2016 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26741168
14.
Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging.
Chem Commun (Camb)
; 51(5): 881-4, 2015 Jan 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-25429667
15.
N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.
ACS Chem Biol
; 10(6): 1425-34, 2015 Jun 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-25706802
16.
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science
; 347(6227): 1256-9, 2015 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25766236
17.
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase.
Chem Commun (Camb)
; 50(38): 4904-7, 2014 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-24691497
18.
Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.
J Med Chem
; 56(14): 5917-30, 2013 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-23822179
19.
Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase.
Eur J Med Chem
; 46(8): 3309-14, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21600680
20.
Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase.
ChemMedChem
; 6(2): 309-20, 2011 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-21246738