[Correction of mineral and protein metabolism by anabolic preparations and vitamin D2 in rats with dental caries]. / Korrektsiia mineral'nogo i belkovogo obmena pri kariece zubov u krys anabolicheskimi preparatiami i vitaminom D2.

The effect of nerabol, namacyte and vitamin D2 introduction (separately or in combination) on the animal mineral and protein metabolism has been studied in the experiment on 210 white Wistar rats with reproduced caries. Biochemical and radioisotopic investigations have permitted determining the quantitative content of phosphorus, calcium, 14C-glycine in the saliva, blood serum, teeth, jaw bones and femur. The data obtained evidence for the pronounced caries-static effect of the tested preparations connected with their active influence on the mineral and protein metabolism of experimental animals as well as for the expediency to use the above drugs for complex prophylaxis and treatment of dental caries normalizing processes.

[Relation of the course of dental caries in schoolchildren to a series of risk factors]. / Zavisimost' techeniia kariesa zubov u shkol'nikov ot riada faktorov riska.

A total of 839 schoolchildren were investigated in different age groups. In compensated and subcompensated caries forms its intensity varied within the limits of 1.76 +/- 0.07 to 3.13 +/- 0.59 and 5.40 +/- 0.15 to 7.29 +/- 0.17, respectively. In decompensation these values were 10.23 +/- 0.34 to 12.28 +/- 0.42. The highest hygienic index (2.0 +/- 0.25) was found in schoolchildren with decompensated form of caries. Sub- and decompensated forms developed with concomitant gastrointestinal, endocrine disorders and CNS trauma.

[Metabolic disorders and their correction in schoolchildren with different forms of caries]. / Metabolicheskie narusheniia i ikh korrektsiia u shkol'nikov s razlichnymi formami kariesa.

Biochemical studies of salivary metabolic disorders in 839 schoolchildren with various forms of caries have revealed salivary pH range to vary from 6.23 +/- 0.02 to 6.80 +/- 0.04, with calcium and inorganic phosphorus levels varying from 4.20 +/- 0.07 to 5.12 +/- 0.11 mg% and from 0.117 +/- 0.05 to 1.041 +/- 0.21 micrograms/ml, respectively. Alkaline phosphatase activity range was found to vary from 107.7 +/- 7.65 to 295.0 +/- 32.3, that of acids from 11.7 +/- 1.81 to 52.5 +/- 4.61 nmol/ml. alpha-ketoglutarate, oxalacetate, phosphoenolpyruvate levels were 3.12 +/- 0.03 to 28.8 +/- 3.41 mumol/ml, fructose diphosphatase content from 2.5 +/- 0.35 to 8.71 +/- 0.72 nmol/s/ml. Use of namacit various dosage forms (5 percent aqueous solution, as a toothpaste component--6 percent, or a component of an adhesive coating) elevated salivary pH level to 7.06. Calcium level remained unchanged, that of inorganic phosphorus increased (p less than 0.001), phosphatase activities grew, as did acid levels and fructose diphosphatase activity, that increased irrespective of the dosage form used (p less than 0.001).

[Effect of prodigiozan on the course of candidiasis of the oral mucosa clinically and in an experiment]. / Vliianie prodigiozana na techenie kandidoza slizistoi obolochki polosti rta v klinike i éksperimente

The effect of various doses of prodigiozan on Candida infection was studied under experimental and clinical conditions. Hamsters and guinea pigs were used in the experiments. Prodigiozan was administered intramuscularly to the hamsters in doses of 100 gamma/kg of the body weight 1 hour before the infection and intracutaneously to the guinea pigs in doses of 50 gamma/kg 2 days before the infection. The results showed that the drug accelerated the recovery of the animals. In complex therapy of a group of 22 patients with candidosis of the mouth mucosa of various localization prodigiozan was administered thrice in doses of 50 gamma/kg. This provided faster elimination of the pathological process.