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1.
N Engl J Med ; 377(2): 154-161, 2017 07 13.
Artículo en Inglés | MEDLINE | ID: mdl-28700843

RESUMEN

Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease. In Europe, cases have been reported only in the southeastern part of the continent. We report two autochthonous cases in Spain. The index patient acquired the disease through a tick bite in the province of Ávila - 300 km away from the province of Cáceres, where viral RNA from ticks was amplified in 2010. The second patient was a nurse who became infected while caring for the index patient. Both were infected with the African 3 lineage of this virus. (Funded by Red de Investigación Cooperativa en Enfermedades Tropicales [RICET] and Efficient Response to Highly Dangerous and Emerging Pathogens at EU [European Union] Level [EMERGE].).


Asunto(s)
Virus de la Fiebre Hemorrágica de Crimea-Congo/aislamiento & purificación , Fiebre Hemorrágica de Crimea , Colon/patología , Trazado de Contacto , Resultado Fatal , Femenino , Virus de la Fiebre Hemorrágica de Crimea-Congo/clasificación , Virus de la Fiebre Hemorrágica de Crimea-Congo/genética , Fiebre Hemorrágica de Crimea/patología , Fiebre Hemorrágica de Crimea/transmisión , Fiebre Hemorrágica de Crimea/virología , Humanos , Transmisión de Enfermedad Infecciosa de Paciente a Profesional , Hígado/patología , Masculino , Persona de Mediana Edad , Necrosis , Reacción en Cadena de la Polimerasa , España
2.
J Hand Surg Am ; 44(7): 619.e1-619.e5, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30344020

RESUMEN

Cutaneous mucormycosis due to Saksenaea vasiformis species is exceptional. There have been about 40 reported cases worldwide, with most being fatal. We report an exceptional nonlethal case of mucormycosis due to S. vasiformis following a spider bite. The patient was in an immunosuppressed state owing to previous chemotherapy and diabetes mellitus. The origin of the inoculation was the bite of a Loxosceles laeta spider, which caused loxoscelism. The initial skin injury was quickly progressive, requiring amputation of the right upper limb. After surgical intervention and suitable antifungal treatment, the patient was discharged with resolution of accompanying pulmonary disease. Infections due to S. vasiformis are probably underdiagnosed. To avoid fatal outcomes, a high index of clinical suspicion in patients with quickly progressive necrotic lesions of soft tissues and systemic dissemination is important.


Asunto(s)
Dermatomicosis/etiología , Dermatomicosis/patología , Mucormicosis/etiología , Mucormicosis/patología , Picaduras de Arañas/complicaciones , Anciano , Dermatomicosis/terapia , Humanos , Masculino , Mucormicosis/terapia
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