RESUMEN
BACKGROUND: The epidemiological surveillance of contact dermatitis is one of the objectives of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. Knowing whether the prevalence of positive tests to the different allergens changes over time is important for this monitoring process. OBJECTIVES: To describe the various temporary trends in allergen positivity in the GEIDAC standard series from 2018 through December 31, 2022. METHODS: This was a multicenter, observational trial of consecutive patients analyzed via patch tests as part of the study of possible allergic contact dermatitises collected prospectively within the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. The data was analyzed using 2 statistical tests: one homogeneity test (to describe the changes seen over time) and one trend test (to see whether the changes described followed a linear trend). RESULTS: A total of 11327 patients were included in the study. Overall, the allergens associated with a highest sensitization were nickel sulfate, methylisothiazolinone, cobalt chloride, methylchloroisothiazolinone/methylisothiazolinone, and fragrance mix i. A statistically significant decrease was found in the percentage of methylisothiazolinone positive tests across the study years with an orderly trend. CONCLUSIONS: Although various changes were seen in the sensitizations trends to several allergens of the standard testing, it became obvious that a high sensitization to nickel, methylchloroisothiazolinone/methylisothiazolinone and fragrances mix i remained. Only a significant downward trend was seen for methylisothiazolinone.
Asunto(s)
Dermatitis Alérgica por Contacto , Dermatitis Atópica , Humanos , Tiazoles , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/epidemiología , Dermatitis Alérgica por Contacto/etiología , Alérgenos/efectos adversos , Pruebas del Parche , Estudios RetrospectivosRESUMEN
BACKGROUND: Psoriasis is a chronic inflammatory dermatosis whose clinical and topographic distribution requires differential diagnosis, or the possible association with allergic contact dermatitis (ACD), requiring patch testing (PT) as part of the diagnostic procedure. OBJECTIVES: To describe the epidemiological, clinical, and allergic profile of patients with a primary or secondary diagnosis of psoriasis undergoing PT and compare them with patients with a diagnosis of ACD at the end of the diagnostic process. METHODS: Cross-sectional study with data from REIDAC from 2018 through 2023 of selected patients with a diagnosis of psoriasis and/or ACD. RESULTS: A total of 11 502 patients were included, 513 of whom had been diagnosed with primary or secondary psoriasis, 3640 with ACD, and 108 with both diseases. Men were more predominant in the groups of patients with psoriasis, psoriasis+ACD, and lesions were more predominantly seen in the hands with little association with atopic factors vs the ACD group. The rate of positivity in PT to the 2022 Spanish battery of allergens was lower in the group with psoriasis only in 27% of the patients. The most common allergens found in the psoriasis group were also the most common ones found in the overall ACD population. CONCLUSIONS: Overall, 36.2% of psoriatic patients tested positive in PT to the 2022 Spanish battery of allergens, which proved that this association is not uncommon. Overall, psoriatic patients had a higher mean age, were more predominantly men, and showed more hand involvement.
Asunto(s)
Dermatitis Alérgica por Contacto , Pruebas del Parche , Psoriasis , Sistema de Registros , Humanos , Psoriasis/epidemiología , Masculino , Dermatitis Alérgica por Contacto/epidemiología , Dermatitis Alérgica por Contacto/diagnóstico , España/epidemiología , Femenino , Estudios Transversales , Persona de Mediana Edad , Adulto , Alérgenos/efectos adversos , Anciano , Adulto JovenRESUMEN
After the meeting held by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) back in October 2021, changes were suggested to the Spanish standard series patch testing. Hydroxyethyl methacrylate (2% pet.), textile dye mixt (6.6% pet.), linalool hydroperoxide (1% pet.), and limonene hydroperoxide (0.3% pet.) were, then, added to the series that agreed upon in 2016. Ethyldiamine and phenoxyethanol were excluded. Methyldibromoglutaronitrile, the mixture of sesquiterpene lactones, and hydroxyisohexyl 3-cyclohexene (Lyral) were alo added to the extended Spanish series of 2022.
Asunto(s)
Dermatitis Alérgica por Contacto , Pruebas del Parche , Humanos , España , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/etiología , Alérgenos/efectos adversosRESUMEN
INTRODUCTION: Oral tetracyclines and topical antibiotics have been used to treat papulopustular rosacea (PPR) for years, but it is not uncommon to find patients who do not respond to this standard treatment. In such refractory cases, oral azithromycin has proven to be an effective option. MATERIAL AND METHOD: We conducted a prospective pilot study of 16 patients with PPR who were treated with oral azithromycin after a lack of response to oral doxycycline and metronidazole gel. At the first visit, the patients were assessed for baseline severity of PPR on a 4-point clinical scale and started on oral azithromycin. At the second visit, response to treatment in terms of improvement from baseline was evaluated on a 3-point scale. Patients were then scheduled for follow-up visits every 12 weeks to assess long-term effectiveness. RESULTS: All 16 patients experienced an improvement in their PPR following treatment with oral azithromycin. Eight weeks after completion of treatment, 14 patients (87.5%) showed complete or almost complete recovery (slight or no residual redness and complete clearance of papules and pustules). Only 2 patients experienced a new episode of inflammatory PPR lesions during follow-up. CONCLUSIONS: The findings of this pilot study suggest that oral azithromycin could be a very effective short-term and long-term treatment for RPP resistant to conventional treatment.
Asunto(s)
Antibacterianos/administración & dosificación , Azitromicina/administración & dosificación , Rosácea/tratamiento farmacológico , Administración Oral , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Estudios Prospectivos , Resultado del TratamientoRESUMEN
We report two cases of xeroderma pigmentosum (XP), with neurologic alterations, representing a partial, although not complete form of the syndrome of De Sanctis-Cacchione. The clinical and aetiological features of the condition are discussed.
Asunto(s)
Encéfalo/patología , Xerodermia Pigmentosa/genética , Adolescente , Atrofia/diagnóstico por imagen , Niño , Femenino , Humanos , Masculino , Radiografía , SíndromeRESUMEN
Infantile myofibromatosis is included in fibrous proliferations of infancy, processes with specific clinic, histology, and evolution, that are characterized by nodules in the skin, bones, and viscera. It's prognosis is varied, depending on whether it is manifested in the solitary or multicentric form. We describe a patient with congenital solitary myofibromatosis.
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Fibroma/congénito , Neoplasias Cutáneas/congénito , Femenino , Fibroma/patología , Humanos , Recién Nacido , Neoplasias Cutáneas/patologíaRESUMEN
Seven cases of P X E, four of them seen in the last six months in our clinic, are revised in the Department of Dermatology Medical-Surgical and Venereology of Sevilla (Faculty of Medicine), realising clinical, histological and ultrastructural studies.
Asunto(s)
Seudoxantoma Elástico/patología , Adulto , Anciano , Tejido Elástico/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/complicaciones , Seudoxantoma Elástico/complicaciones , Seudoxantoma Elástico/genética , Piel/patología , Xerodermia Pigmentosa/complicacionesRESUMEN
The fortieth observation in the world literature and the four in Spain of Zinsser-Cole-Engman. Syndrome is presented, and for this reason we have reviewed the clinical, hematological, genetical and diagnostic features of this disease.
Asunto(s)
Carcinoma de Células Escamosas/patología , Leucoplasia Bucal/patología , Neoplasias de la Boca/patología , Lesiones Precancerosas/patología , Síndrome Rothmund-Thomson/patología , Enfermedades de la Piel/patología , Adulto , Atrofia , Neoplasias Esofágicas/patología , Humanos , Masculino , Mucosa Bucal/patología , Trastornos de la Pigmentación/patología , SíndromeRESUMEN
In a series of 1,011 women seen in the Diagnosis Center of Sexually Transmitted Diseases of the Faculty of Medicine of Seville, we study the prevalence of cervical infections caused by Neisseria gonorrhoeae and/or Chlamydia trachomatis and also mucopurulent cervicitis (CMP), these last diagnosed by the presence of more than 10 polymorphonuclear leukocytes x 1,000 magnification in Gram stain of secretion or endocervical mucopus. We calculate the predictive value that the diagnosis of the CMP had in detecting cervical infection by chlamydia and gonococcus. N. gonorrhoeae was isolated in 56 patients (5.5%), C. trachomatis in 83 (8.2%) and both in 15 (1.5%). In all, 154 women presented cervical infections, which correlates to a prevalence of 15.2%. CMP was diagnosed in 267 patients and, of these, 43.4% had cervical infection accused by N. gonorrhoeae and/or C. trachomatis. The diagnosis criteria of CMP used as predictors of cervical infection, had a sensibility of 0.75 and a specificity of 0.82, with a positive predictive value of 0.42.
Asunto(s)
Infecciones por Chlamydia , Gonorrea , Cervicitis Uterina/etiología , Infecciones por Chlamydia/epidemiología , Chlamydia trachomatis/aislamiento & purificación , Femenino , Gonorrea/epidemiología , Hospitales Especializados , Hospitales Universitarios , Humanos , Neisseria gonorrhoeae/aislamiento & purificación , Estudios Retrospectivos , España , Cervicitis Uterina/epidemiologíaRESUMEN
Twelve observations of Behcet's syndrome are described, which comply with the diagnostic criteria of O'DUFFY. The clinic symptomatology is reviewed and compared with those found by other authors.
Asunto(s)
Síndrome de Behçet/patología , Adolescente , Corticoesteroides/uso terapéutico , Adulto , Síndrome de Behçet/tratamiento farmacológico , Síndrome de Behçet/inmunología , Niño , Colchicina/uso terapéutico , Quimioterapia Combinada , Femenino , Humanos , Inosina Pranobex/uso terapéutico , Masculino , Estomatitis Aftosa/patología , Uveítis/patologíaRESUMEN
After observing a case of pemphigoid in a 5-month-old infant, verified inmunologically, we comment on the clinical, histological, biochemical and immunological tests and review the benign chronic bullous dermatosis of the childhood.
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Penfigoide Ampolloso/patología , Enfermedades Cutáneas Vesiculoampollosas/patología , Esofagitis Péptica/complicaciones , Femenino , Hernia Hiatal/complicaciones , Humanos , Lactante , Penfigoide Ampolloso/complicaciones , Penfigoide Ampolloso/inmunología , Atelectasia Pulmonar/complicacionesRESUMEN
We report a family with aplasia cutis congenita, an extremely rare condition. Particular attention is paid to the clinical, etiologic, and genetic characteristics. The only possible treatment, as in the first case in this family, is excision and reconstruction by dermatologic surgery procedures.
Asunto(s)
Anomalías Cutáneas , Adulto , Alopecia/congénito , Alopecia/genética , Preescolar , Femenino , Humanos , Masculino , Persona de Mediana Edad , Linaje , Cuero Cabelludo/anomalías , Cuero Cabelludo/cirugía , Úlcera/congénitoRESUMEN
Congenital fistula of the lower lip was observed in 3 members of a family. There was no evidence of associated congenital malformations. In the father, we performed fistulography with radiopaque substance, showing that the fistular tract extended beyond the orbicularis oris muscle, a feature with no previous report in the literature.