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1.
Foot Ankle Surg ; 25(3): 348-353, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30321979

RESUMEN

BACKGROUND: Recurrence of hallux valgus (HV) is a common complication after forefoot surgery for rheumatoid forefoot deformities. The aim of this study is to evaluate the impact of hindfoot malalignment on recurrence. METHODS: This was a retrospective observational study designed to analyze the radiographic outcomes of 87 feet in 64 patients with rheumatoid arthritis treated with a joint-preserving surgery for HV deformity. Differences in hindfoot alignment preoperatively between the recurrence and nonrecurrence groups was compared. RESULTS: There were no significant differences in hindfoot alignment preoperatively between groups. To estimate the impact of technical problems, the HV and intermetatarsal angles measured from radiographs 3 months postoperatively were compared between groups. The HV angles in the recurrence group were significantly larger than those in the nonrecurrence group (p=0.02). CONCLUSIONS: There were no significant differences between preoperative hindfoot malalignment and postoperative recurrence of HV in rheumatoid forefoot surgeries.


Asunto(s)
Artritis Reumatoide/cirugía , Antepié Humano/cirugía , Hallux Valgus/diagnóstico por imagen , Talón/anomalías , Complicaciones Posoperatorias/diagnóstico por imagen , Adulto , Anciano , Artritis Reumatoide/fisiopatología , Femenino , Antepié Humano/diagnóstico por imagen , Antepié Humano/fisiopatología , Hallux Valgus/cirugía , Talón/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Periodo Preoperatorio , Radiografía , Recurrencia , Estudios Retrospectivos
2.
Mod Rheumatol ; 28(6): 976-980, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29325462

RESUMEN

OBJECTIVE: Since IL-6 has been associated with activation of the coagulation cascade and upregulation of fibrinogen transcription, we retrospectively tested the hypothesis that patients with rheumatoid arthritis (RA) treated with tocilizumab (TCZ) may lose more blood when undergoing total knee arthroplasty (TKA). METHODS: This study included 115 RA patients who underwent primary TKA and were preoperatively tested for fibrinogen levels. The blood volume of each patient was calculated using the Nadler formula, and estimated blood loss after TKA was calculated as the change between pre-operative and post-operative hematocrits. If salvaged blood was reinfused, the volume was measured and added to the volume of the estimated blood loss. RESULTS: We observed that patients treated with TCZ had significantly lower pre-operative fibrinogen levels than those not treated with TCZ (190.0 mg/dL versus 347.0 mg/dL, respectively; p = .00018). We also observed a statistically significant increase in mean total volume of estimated blood loss after TKA in RA patients who had been treated with TCZ compared with those not treated with TCZ (797.1 mL versus 511.4 mL, respectively; p = .0039). CONCLUSION: TCZ treatment in patients with RA may increase the risk of blood loss after TKA because of decreased fibrinogen levels.


Asunto(s)
Anticuerpos Monoclonales Humanizados/efectos adversos , Antirreumáticos/efectos adversos , Artritis Reumatoide/tratamiento farmacológico , Artroplastia de Reemplazo de Rodilla/efectos adversos , Fibrinógeno/análisis , Hemorragia Posoperatoria/epidemiología , Anciano , Anticuerpos Monoclonales Humanizados/uso terapéutico , Antirreumáticos/uso terapéutico , Artritis Reumatoide/sangre , Artritis Reumatoide/cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad
3.
J Hand Surg Am ; 41(6): e129-34, 2016 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-27118392

RESUMEN

PURPOSE: To assess the outcomes of a modified extensor pollicis longus (EPL) rerouting technique for boutonniere deformity of the thumb in patients with rheumatoid arthritis. METHODS: A total of 21 thumbs in 18 patients with a mean age of 63 years were retrospectively analyzed after an average follow-up period of 3.2 years. The preoperative deformities were classified as either mild (5 thumbs) or moderate (16 thumbs). After either metacarpophalangeal (MCP) joint synovectomy or implant arthroplasty, the ulnarly dislocated EPL tendon was reduced dorsally and sutured to the dorsal base of the proximal phalanx. If the interphalangeal (IP) joint extended with manual traction on the proximal portion of the extensor pollicis brevis tendon, no further treatment was considered. If the IP joint did not extend with this maneuver, the insertion of the extensor pollicis brevis tendon was dissected and transferred to the distal portion of the EPL tendon. RESULTS: The average MCP joint extensor lag improved from 62° (range, 32° to 85°) before surgery to 17° (range, active extension 12° to extensor lag 70°) at the final follow-up (P < .05), whereas average MCP joint flexion decreased from 83° (range, 52° to 95°) to 68° (range, 30° to 90°) (P < .05). Hyperextension at the IP joint was improved from 30° (range, 10° to 50°) before surgery to an average extensor lag of 2° (range, extensor lag 24° to hyperextension 20°) at the final follow-up. The average combined MCP and IP motion did not significantly change. The boutonniere deformity was improved in 18 of 21 thumbs. The 3 failures all had moderate-stage deformity prior to treatment. CONCLUSIONS: A modified EPL rerouting technique provided satisfactory results together with a low risk of IP joint extension loss. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.


Asunto(s)
Artritis Reumatoide/complicaciones , Deformidades Adquiridas de la Mano/cirugía , Rango del Movimiento Articular/fisiología , Transferencia Tendinosa/métodos , Pulgar/anomalías , Pulgar/cirugía , Adulto , Anciano , Artritis Reumatoide/diagnóstico , Estudios de Cohortes , Femenino , Deformidades Adquiridas de la Mano/diagnóstico por imagen , Deformidades Adquiridas de la Mano/etiología , Fuerza de la Mano , Humanos , Masculino , Articulación Metacarpofalángica/fisiopatología , Articulación Metacarpofalángica/cirugía , Persona de Mediana Edad , Dimensión del Dolor , Cuidados Posoperatorios , Recuperación de la Función , Estudios Retrospectivos , Transferencia Tendinosa/rehabilitación , Pulgar/diagnóstico por imagen , Adulto Joven
4.
Mod Rheumatol ; 26(5): 702-7, 2016 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26873662

RESUMEN

OBJECTIVE: The Sauvé-Kapandji procedure is a common surgical procedure for rheumatoid wrist, which involves fixing dissected ulnar head to the distal radius in order to provide "bony support" to the carpus. The purpose of this study was to investigate whether the position of the fixed ulnar head was associated with postsurgical carpus translocation. METHODS: We retrospectively reviewed radiographs of 40 patients who underwent the Sauvé-Kapandji procedure and were subsequently followed up for over two years. The association between the fixed ulnar head position and postsurgical carpus translocation was statistically analysed with a confidence interval of 95% (p < 0.05). RESULTS: Multiple regression analysis suggested that the radial inclination of the fixed ulnar head, the absence of increases in ulnar variance, and wide "bony support" were significantly associated with less postsurgical carpal translocation. CONCLUSION: Our study indicated that good concordance between the "bony support" and the carpus might be important in reducing postsurgical carpus translocation.


Asunto(s)
Artritis Reumatoide/cirugía , Radio (Anatomía)/cirugía , Cúbito/cirugía , Articulación de la Muñeca/cirugía , Adulto , Anciano , Artritis Reumatoide/diagnóstico por imagen , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Ortopédicos/métodos , Radiografía , Radio (Anatomía)/diagnóstico por imagen , Estudios Retrospectivos , Resultado del Tratamiento , Cúbito/diagnóstico por imagen , Articulación de la Muñeca/diagnóstico por imagen
5.
Mod Rheumatol ; 26(2): 313-4, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26382579

RESUMEN

Recent advances in medication choices have strikingly improved the management of rheumatoid arthritis. However, medication alone cannot place back already deformed joints. Thus, to prevent metacarpophalangeal (MP) joint destruction, joint deformity correction should be considered since mechanical stress induced by finger motions will eventually destruct the undestructed joint, with a possibility of recurrence and future implant arthroplasty in mind since RA still remains as a progressive disease. We report a modified metacarpal shortening osteotomy for correcting MP joint deformity. The advantage of our technique over previous osteotomies is that it easily allows for subsequent implant arthroplasty even after the recurrence of joint deformity/destruction. Major modifications include that the metacarpal is shortened at its mid-shaft and the osteotomy is performed vertical to the shaft and fixed with surgical wiring. We believe that combination therapy consisting of medication and surgery is preferable to prevent joint destruction, even in this age of biological agents.


Asunto(s)
Artritis Reumatoide/cirugía , Huesos del Metacarpo/cirugía , Articulación Metacarpofalángica/cirugía , Osteotomía/métodos , Humanos , Prótesis e Implantes
6.
Mod Rheumatol ; 26(2): 206-10, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26143650

RESUMEN

OBJECTIVE: This retrospective study was designed to evaluate the outcomes of four different surgical reconstructions for extensor tendon ruptures in ulnar three fingers in 48 patients with rheumatoid arthritis. METHODS: The following four techniques were performed; palmaris longus tendon grafting (PL group; n = 9), extensor indicis proprius (EIP) tendon transfers (EIP group; n = 8), end-to-side transfers with tension-reduced early mobilization (End-to-side group; n = 16), and a combination of end-to-side and EIP transfers (Combination group; n = 15). Loss of extension was evaluated to determine the mean postoperative range of motion of the metacarpophalangeal (MP) joint and clinical outcomes were categorized using modified Geldmacher criteria. RESULTS: Combination group demonstrated the best mean MP joint extension (-3°), followed by End-to-side group (-12°), EIP group (-16°), and PL group (-21°). Combination group yielded the best clinical outcomes with all cases showing good results. CONCLUSIONS: The combination of end-to-side and EIP transfer was an effective surgical reconstruction procedure for triple fingers extension loss.


Asunto(s)
Artritis Reumatoide/cirugía , Traumatismos de los Tendones/cirugía , Transferencia Tendinosa/métodos , Tendones/cirugía , Adulto , Anciano , Artritis Reumatoide/complicaciones , Artritis Reumatoide/fisiopatología , Femenino , Humanos , Masculino , Articulación Metacarpofalángica/fisiopatología , Persona de Mediana Edad , Rango del Movimiento Articular/fisiología , Estudios Retrospectivos , Traumatismos de los Tendones/complicaciones , Traumatismos de los Tendones/fisiopatología , Resultado del Tratamiento
7.
Artículo en Inglés | MEDLINE | ID: mdl-25765011

RESUMEN

Comprehensive whole-body counter surveys of Miharu-town school children have been conducted for four consecutive years, in 2011-2014. This represents the only long-term sampling-bias-free study of its type conducted after the Fukushima Dai-ichi accident. For the first time in 2014, a new device called the Babyscan, which has a low (134/137)Cs MDA of <50 Bq/body, was used to screen the children shorter than 130 cm. No child in this group was found to have detectable level of radiocesium. Using the MDAs, upper limits of daily intake of radiocesium were estimated for each child. For those screened with the Babyscan, the upper intake limits were found to be ≲1 Bq/day for (137)Cs. Analysis of a questionnaire filled out by the children's parents regarding their food and water consumption shows that the majority of Miharu children regularly consume local and/or home-grown rice and vegetables. This however does not increase the body burden.


Asunto(s)
Recolección de Datos , Accidente Nuclear de Fukushima , Instituciones Académicas , Recuento Corporal Total , Adolescente , Carga Corporal (Radioterapia) , Radioisótopos de Cesio/análisis , Niño , Ingestión de Líquidos , Femenino , Humanos , Japón , Masculino
8.
Artículo en Inglés | MEDLINE | ID: mdl-26460321

RESUMEN

BABYSCAN, a whole-body counter (WBC) for small children was developed in 2013, and units have been installed at three hospitals in Fukushima Prefecture. Between December, 2013 and March, 2015, 2707 children between the ages of 0 and 11 have been scanned, and none had detectable levels of radioactive cesium. The minimum detectable activities (MDAs) for (137)Cs were ≤ 3.5 Bq kg(-1) for ages 0-1, decreasing to ≤ 2 Bq kg(-1) for ages 10-11. Including the (134)Cs contribution, these translate to a maximum committed effective dose of ∼ 16 µSv y(-1) even for newborn babies, and therefore the internal exposure risks can be considered negligibly small.Analysis of the questionnaire filled out by the parents of the scanned children regarding their families' food and water consumption revealed that the majority of children residing in the town of Miharu regularly consume local or home-grown rice and vegetables, while in Minamisoma, a majority avoid tap water and produce from Fukushima. The data show, however, no correlation between consumption of locally produced food and water and the children's body burdens.


Asunto(s)
Accidente Nuclear de Fukushima , Monitoreo de Radiación , Encuestas y Cuestionarios , Recuento Corporal Total , Distribución por Edad , Niño , Preescolar , Femenino , Hospitales/estadística & datos numéricos , Humanos , Lactante , Recién Nacido , Masculino , Factores de Tiempo
9.
Mod Rheumatol ; 25(3): 358-61, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25295920

RESUMEN

OBJECTIVES: A self-administered foot evaluation questionnaire (SAFE-Q) was developed by the Japanese Society for Surgery of the Foot (JSSF). The aim of this study is to evaluate the validity and responsiveness of the SAFE-Q in patients with rheumatoid arthritis (RA). METHODS: In total, 180 patients with RA answered the SAFE-Q. Of 180 patients, 34 answered the SAFE-Q twice, preoperatively and postoperatively, to assess responsiveness. Construct validity was tested by comparing the 5 SAFE-Q subscales and the JSSF standard rating system for the RA foot and ankle scale (JSSF-RA), a Japanese version of the Health Assessment Questionnaire (JHAQ), disease activity score in 28 joints (DAS28), simplified disease activity index (SDAI), and clinical disease activity index (CDAI). Responsiveness was examined by calculating the standardized response mean (SRM) and effect size (ES) 3 months after surgery. RESULTS: There were moderate correlations between the SAFE-Q and the JSSF-RA and JHAQ. Conversely, a low correlation was observed between the SAFE-Q and DAS28, SDAI, and CDAI. The responsiveness was high, with an SRM of 0.9 and ES of 0.7 for pain subscales. CONCLUSION: SAFE-Q is a useful tool for assessing the foot and ankle in RA patients.


Asunto(s)
Artritis Reumatoide/fisiopatología , Evaluación de la Discapacidad , Pie/fisiopatología , Dolor/diagnóstico , Calidad de Vida , Encuestas y Cuestionarios , Actividades Cotidianas , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dolor/fisiopatología , Dimensión del Dolor , Índice de Severidad de la Enfermedad
10.
Clin J Sport Med ; 24(4): 358-9, 2014 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-24389626

RESUMEN

A 63-year-old man presented with a complaint of left ulnar wrist pain after playing golf. Computed tomography was used to detect a fracture at the base of the hook of hamate. Low-intensity pulsed ultrasound without a splint for immobilization was started, and bone union was confirmed 12 months after the ultrasound treatment started. The patient returned to play golf without any symptoms or complications. The present case suggests that ultrasound treatment is effective for fractures of the hook of hamate even in an older middle-aged patient. Ultrasound treatment is more time consuming than other surgical treatments, but it can be an important, safe, and noninvasive therapeutic alternative to surgery for fractures of the hook of hamate.


Asunto(s)
Fracturas Óseas/terapia , Hueso Ganchoso/lesiones , Traumatismos de la Mano/terapia , Humanos , Masculino , Persona de Mediana Edad , Terapia por Ultrasonido
11.
Artículo en Inglés | MEDLINE | ID: mdl-24919760

RESUMEN

Comprehensive whole-body counter surveys covering over 93% of the school children between the ages of 6 and 15 in Miharu town, Fukushima Prefecture, have been conducted for three consecutive years, in 2011, 2012 and 2013. Although the results of a questionnaire indicate that approximately 60% of the children have been regularly eating local or home-grown rice, in 2012 and 2013 no child was found to exceed the (137)Cs detection limit of 300 Bq/body.


Asunto(s)
Recolección de Datos , Accidente Nuclear de Fukushima , Plantas de Energía Nuclear , Recuento Corporal Total , Adolescente , Distribución por Edad , Niño , Contaminación Radiactiva de Alimentos/estadística & datos numéricos , Humanos , Instituciones Académicas , Estudiantes , Encuestas y Cuestionarios
12.
Artículo en Inglés | MEDLINE | ID: mdl-23574806

RESUMEN

The Fukushima Dai-ichi NPP accident contaminated the soil of densely-populated regions in Fukushima Prefecture with radioactive cesium, which poses significant risks of internal and external exposure to the residents. If we apply the knowledge of post-Chernobyl accident studies, internal exposures in excess of a few mSv/y would be expected to be frequent in Fukushima.Extensive whole-body-counter surveys (n = 32,811) carried out at the Hirata Central Hospital between October, 2011 and November, 2012, however show that the internal exposure levels of residents are much lower than estimated. In particular, the first sampling-bias-free assessment of the internal exposure of children in the town of Miharu, Fukushima, shows that the (137)Cs body burdens of all children (n = 1,383, ages 6-15, covering 95% of children enrolled in town-operated schools) were below the detection limit of 300 Bq/body in the fall of 2012. These results are not conclusive for the prefecture as a whole, but are consistent with results obtained from other municipalities in the prefecture, and with prefectural data.


Asunto(s)
Recolección de Datos , Accidente Nuclear de Fukushima , Plantas de Energía Nuclear , Monitoreo de Radiación , Recuento Corporal Total , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Radioisótopos de Cesio/análisis , Niño , Exposición a Riesgos Ambientales/análisis , Hospitales/estadística & datos numéricos , Humanos , Persona de Mediana Edad , Factores de Tiempo , Adulto Joven
13.
Mod Rheumatol ; 23(5): 953-8, 2013 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23070360

RESUMEN

OBJECTIVES: The introduction of powerful antirheumatic drugs has dramatically improved the treatment of rheumatoid arthritis (RA), leading clinicians to reconsider the benefits of joint preservation for rheumatoid forefoot deformities. We have employed joint-preserving forefoot surgeries, including rotational closing-wedge osteotomy of the first metatarsal. The aim of our study is to assess the short-term results of this procedure. METHODS: From January 2011 through December 2011, 35 feet were treated with this procedure. Subjective, functional, and radiographic outcomes were surveyed. RESULTS: The mean Japanese Society for Surgery of the Foot improved from a preoperative level of 52.6 to 68.7 postoperatively. The average hallux valgus and intermetatarsal angles improved from 47.3° preoperatively to 17.5° postoperatively, and from 16.7° preoperatively to 9.0° postoperatively, respectively. To assess the repositioning of pronation deformities of the first metatarsal, the position of the medial sesamoid was also surveyed according to the measurement system proposed by Hardy and Clapham. All feet except two were classified as grade V or higher preoperatively; 25 of these were grade IV or lower at the latest follow-up. CONCLUSIONS: Rotational closing-wedge osteotomy of the first metatarsal was beneficial for correcting forefoot deformities in RA over the short term.


Asunto(s)
Artritis Reumatoide/cirugía , Huesos Metatarsianos/cirugía , Articulación Metatarsofalángica/cirugía , Osteotomía/métodos , Anciano , Artritis Reumatoide/diagnóstico por imagen , Femenino , Hallux Valgus/diagnóstico por imagen , Hallux Valgus/cirugía , Humanos , Masculino , Huesos Metatarsianos/diagnóstico por imagen , Articulación Metatarsofalángica/diagnóstico por imagen , Persona de Mediana Edad , Radiografía , Resultado del Tratamiento
14.
Mod Rheumatol ; 22(2): 209-15, 2012 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21761229

RESUMEN

The treatment of rheumatoid arthritis (RA) has improved dramatically with the advent of the latest generation of disease-modifying antirheumatic drugs. Despite these advances, in some patients inflammation is not diminished sufficiently to prevent irreversible musculoskeletal damage, thereby necessitating surgical intervention to reduce pain and improve function. For RA treatment, Japanese orthopedic surgeons also prescribe medication. In this study, we examined whether this Japanese system is effective for RA treatment. We analyzed the clinical condition of RA patients treated by rheumatologists and those treated by orthopedists in a linked registry study using information from a large observational cohort of RA patients followed every half year from 2000 to 2010 (the IORRA cohort). Two groups of patients were compared: patients treated by rheumatologists (rheumatologic group) and patients treated by orthopedists (orthopedic group). The results revealed that patients in the orthopedic group were older, more likely to be female, and had a longer disease duration than patients in the rheumatologic group. The proportion of patients with a history of joint surgery was also much higher in the orthopedic group than in the rheumatologic group. The average scores on the Japanese version of the Health Assessment Questionnaire, and the remission ratio determined using a Boolean-based definition gradually increased from 2000 until 2010, and these findings were consistently better in the rheumatologic group than in the orthopedic group. These data suggest that patients treated primarily by orthopedists are more likely to have long-standing RA compared to patients treated by rheumatologists. Therefore, it is critical for rheumatologists and orthopedists to complement each other medically in the treatment of RA patients.


Asunto(s)
Antirreumáticos/uso terapéutico , Artritis Reumatoide/tratamiento farmacológico , Ortopedia/métodos , Grupo de Atención al Paciente/estadística & datos numéricos , Reumatología/métodos , Factores de Edad , Anciano , Femenino , Estado de Salud , Humanos , Masculino , Persona de Mediana Edad , Relaciones Médico-Paciente , Inducción de Remisión , Factores Sexuales , Encuestas y Cuestionarios , Factores de Tiempo , Resultado del Tratamiento
15.
Mod Rheumatol ; 21(5): 469-75, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21318306

RESUMEN

The aim of this study was to identify risk factors for acute surgical-site infection (SSI) after total joint arthroplasty in rheumatoid arthritis (RA) patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs (DMARDs). We performed a retrospective study of all consecutive total hip (THA) and total knee (TKA) arthroplasties performed during a 5-year period (THA 81; TKA 339). Multivariate logistic regression analysis was performed to identify SSI risk factors. Of the patients undergoing THA or TKA, 24 cases (5.7%) developed a superficial incisional SSI requiring the use of antibiotics and three cases (0.7%) developed an organ/space SSI necessitating surgical treatment to remove the artificial joint prosthesis. Multivariate logistic regression analysis revealed that the use of biologic DMARDs [P = 0.0007, odds ratio (OR) = 5.69; 95% confidence interval (CI) 2.07-15.61] and longer RA duration (P = 0.0003, OR = 1.09; 95% CI 1.04-1.14) were the only significant risk factors for acute SSI. Furthermore, an analysis that individually evaluated major agents (n > 10) adjusted for disease duration indicated that tumor necrosis factor alpha blockers increased the risk of SSI (infliximab P = 0.001, OR = 9.80, 95% CI 2.41-39.82; etanercept P = 0.0003, OR = 9.16, 95% CI 2.77-30.25). We found that the use of infliximab or etanercept and longer disease duration were associated with an increased risk of acute SSI in RA patients. Prospective studies are thus needed to determine the safety of biologic DMARDs in the perioperative period.


Asunto(s)
Antirreumáticos/uso terapéutico , Artritis Reumatoide , Artroplastia de Reemplazo de Cadera/estadística & datos numéricos , Artroplastia de Reemplazo de Rodilla/estadística & datos numéricos , Productos Biológicos/uso terapéutico , Infecciones Relacionadas con Prótesis/epidemiología , Anciano , Artritis Reumatoide/tratamiento farmacológico , Artritis Reumatoide/epidemiología , Artritis Reumatoide/cirugía , Femenino , Humanos , Huésped Inmunocomprometido , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Infecciones Oportunistas/epidemiología , Infecciones Oportunistas/inmunología , Infecciones Relacionadas con Prótesis/inmunología , Factores de Riesgo , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
16.
Mod Rheumatol ; 21(5): 476-81, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21373798

RESUMEN

Though excellent clinical results have been reported for total joint arthroplasty (TJA) in rheumatoid arthritis (RA) patients, the longitudinal effects of TJA on pain, physical function, and health-related quality of life in RA patients remain unknown. This study aimed to assess changes in disease activity and health-related quality of life after TJA in patients with established RA. We analyzed the effect of total knee arthroplasty (TKA) and total hip arthroplasty (THA) on RA disease activity in an observational cohort of RA patients. Of the registered RA patients, 333 TKA and 77 THA patients were followed for 5 years after surgery. RA disease activity and health-related quality of life were measured using the Disease Activity Score 28 (DAS28) and a Japanese version of the Stanford health assessment questionnaire (J-HAQ). The mean DAS28 in TKA patients decreased from 4.66 (preoperatively) to 4.02 (3 years postoperatively) and to 3.94 (5 years postoperatively); the mean DAS28 in THA patients decreased from 4.41 (preoperatively) to 3.99 (3 years postoperatively) and to 3.92 (5 years postoperatively). The mean J-HAQ for TKA remained essentially unchanged, ranging from 1.48 (preoperatively) to 1.45 (3 years postoperatively) and to 1.47 (5 years postoperatively); the mean J-HAQ for THA also remained unchanged, ranging from 1.74 (preoperatively) to 1.74 (3 years postoperatively) and to 1.73 (5 years postoperatively). Of the total J-HAQ score, the lower limb score improved while the upper limb score worsened. Although TKA and THA improve clinical outcomes in damaged knees and hips and have a positive secondary systemic effect on RA disease activity, they have not had a continuously good effect on the measures of health-related quality of life. We conclude that tight control of RA disease activity is indicated for those patients with TKA and/or THA.


Asunto(s)
Artritis Reumatoide/cirugía , Artritis Reumatoide/terapia , Artroplastia de Reemplazo de Cadera , Artroplastia de Reemplazo de Rodilla , Estado de Salud , Calidad de Vida , Adulto , Anciano , Artritis Reumatoide/fisiopatología , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios , Resultado del Tratamiento
17.
Rheumatology (Oxford) ; 49(2): 341-7, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19965973

RESUMEN

OBJECTIVE: TNF-alpha blockers reportedly increase the risk of complications in rheumatic patients following surgery. Whereas deep venous thrombosis (DVT) is a significant complication after orthopaedic surgery of the lower limbs, the risk for DVT in RA patients receiving TNF blockers remains unclear. The aim of this study was to identify complications that can be attributed to the use of TNF-alpha blocker therapy. METHODS: In a retrospective 1:1 pair-matched case-control study, 64 anti-TNF-treated RA surgeries (TNF group) and 64 surgeries treated with conventional DMARDs (DMARDS group) were evaluated for surgical site infection (SSI), DVT and recurrence of arthritis (flare-up). Multivariate logistic regression analysis was performed to test the association of SSI or DVT with the putative risk factors. RESULTS: Regression analysis identified the use of TNF blockers as a risk factor for SSI [P = 0.036; odds ratio (OR) = 21.80] and development of DVT (P = 0.03; OR = 2.83) after major orthopaedic surgery: 12.5% (8/64) of the patients in the TNF group had SSI, whereas 2% (1/64) of those in the DMARDs group had SSI. Fifty-one per cent (23/45) of the TNF group, but only 26% (12/45) of the DMARDs group was DVT positive. Flare-ups during the perioperative period were found in 17.2% (11/64) of all patients, and no delay in wound healing occurred in either group. CONCLUSIONS: These data suggest that the use of TNF blockers is a likely cause of SSI and DVT development in RA patients following major orthopaedic surgery.


Asunto(s)
Antirreumáticos/efectos adversos , Artritis Reumatoide/cirugía , Complicaciones Posoperatorias , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Antirreumáticos/administración & dosificación , Antirreumáticos/uso terapéutico , Artritis Reumatoide/tratamiento farmacológico , Métodos Epidemiológicos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Infecciones Oportunistas/inducido químicamente , Atención Perioperativa/métodos , Recurrencia , Infección de la Herida Quirúrgica , Trombosis de la Vena/inducido químicamente
18.
Mod Rheumatol ; 20(5): 452-7, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20490599

RESUMEN

Though excellent clinical results have been reported for total knee arthroplasty (TKA) in rheumatoid arthritis (RA) patients, the medium-term effect of TKA on RA disease activity remains unknown. This analysis aimed to assess changes in disease activity after TKA in patients with established RA. We analyzed the systemic effects of TKA on RA disease activity 3 years after intervention. Routine clinical and laboratory assessments were recorded at baseline, less than less than 0.5 years after TKA, and 3 years after TKA. Of the registered RA patients, 130 TKA patients were followed for 3 years after surgery. RA disease activity was measured using the Disease Activity Score 28 (DAS28). Patients were divided into three groups by preoperative baseline DAS28: low (DAS28 ≤ 3.2, n = 8), moderate (DAS28 > 3.2 but ≤5.1, n = 68), and high (DAS28 > 5.1, n = 54) disease activity. The postoperative DAS28 (<0.5 years [DAS1] and 3 years [DAS3] after surgery) scores of each patient were compared to their baseline (DAS0) scores using the paired t-test. The mean DAS28 decreased from 4.85 (DAS0) to 4.14 (DAS1; P = 1.07E-12), and this decrease was sustained at 3 years (DAS3 = 3.97; P = 4.73E-15). Subanalysis results revealed a systemic effect of TKA on disease activity in patients with moderate or high disease activity (DAS0 = 4.33; DAS1 = 3.72 [P = 5.94E-06]; DAS3 = 3.81 [P = 7.89E-06]; and DAS0 = 5.79; DAS1 = 4.86 [P = 1.14E-08]; DAS3 = 4.37 [P = 1.03E-11], respectively). While no significant changes in medication were noted, the average dose of prednisolone tended to decrease over time. We conclude that TKA, which is known to result in good clinical outcomes for damaged knees, has a secondary systemic effect on RA disease activity. Combination therapy consisting of medical treatment and surgical intervention is thought to effectively improve the condition of RA patients who have destructive arthritis in the knee joint, with the effect lasting for at least 3 years.


Asunto(s)
Artritis Reumatoide/cirugía , Artroplastia de Reemplazo de Rodilla , Artritis Reumatoide/tratamiento farmacológico , Artritis Reumatoide/fisiopatología , Terapia Combinada , Evaluación de la Discapacidad , Femenino , Estado de Salud , Humanos , Masculino , Persona de Mediana Edad , Dolor , Dimensión del Dolor , Índice de Severidad de la Enfermedad
19.
J Hand Surg Asian Pac Vol ; 25(4): 495-498, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-33115361

RESUMEN

A 49-year-old woman with rheumatoid arthritis who underwent replacement arthroplasty of second to fifth left metacarpophalangeal joints with silastic implant seven years ago presented with a complaint of mild pain and discomfort on the replaced joint of index finger. Ulnar deviation had relapsed, with severe swan neck deformities. Computed tomography examination demonstrated that the tip of the stem of the silicon implant penetrated the second metacarpal. We confirmed that finding surgically, and we performed a revision surgery successfully with autogenous bone grafting from distal radius. As the patient had undergone finger joint replacement surgery with silastic implant, nontraumatic perforation of the bone cortex by the implant could happen in a long-term process. On long-term follow up of silastic arthroplasty of finger joint, the possibility of nontraumatic perforation of the finger bone by the prosthesis should be considered, especially in the coexistence of severe finger deformities such as swan neck deformity.


Asunto(s)
Artritis Reumatoide/cirugía , Artroplastia para la Sustitución de Dedos , Prótesis Articulares/efectos adversos , Huesos del Metacarpo/lesiones , Femenino , Humanos , Huesos del Metacarpo/diagnóstico por imagen , Huesos del Metacarpo/cirugía , Articulación Metacarpofalángica/cirugía , Persona de Mediana Edad , Radio (Anatomía)/trasplante
20.
Int J Surg Case Rep ; 68: 96-99, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32126355

RESUMEN

INTRODUCTION: A volar dislocation of the metacarpophalangeal (MCP) joint of the thumb is a rare trauma, and in combination with a radial collateral ligament (RCL) injury is much rarer. We present a surgical case with a recurrent volar dislocation of the MCP joint of the thumb with RCL injury. PRESENTATION OF CASE: A 47-year-old man was referred to our hospital in the subacute phase. Open reduction was performed through a dorsal incision and the RCL was repaired. X-rays taken six weeks later revealed a recurrent dislocation of the MCP joint. At the revision surgery, the extensor pollicis brevis (EPB) was detached from the proximal phalanx. As there was volar tightness, the volar plate was incised horizontally and the EPB was attached to the proximal phalanx. The final X-rays six months post-operatively revealed that the MCP joint was slightly subluxated but there was no pain on motion. DISCUSSION: This case revealed that it is not enough only to repair the RCL to reduce a volar dislocation of the MCP joint of the thumb with an RCL injury. It revealed that re-attachment of the extensor tendons and the volar procedure are also important for a perfect reduction of a recurrent volar dislocation of the MCP joint of the thumb. CONCLUSION: For a volar dislocation of the MCP joint of the thumb with RCL injury, it is important not only to repair the RCL, but also to perform arthroplasty with the extensor tendons and a volar procedure to prevent recurrent dislocation after surgery.

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