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1.

The proteomic landscape of genotoxic stress-induced micronuclei.

MacDonald, Kate M; Khan, Shahbaz; Lin, Brian; Hurren, Rose; Schimmer, Aaron D; Kislinger, Thomas; Harding, Shane M.

Mol Cell ; 84(7): 1377-1391.e6, 2024 Apr 04.

Artículo en Inglés | MEDLINE | ID: mdl-38423013

2.

Venetoclax resistance in acute myeloid leukaemia-Clinical and biological insights.

Nachmias, Boaz; Aumann, Shlomzion; Haran, Arnon; Schimmer, Aaron D.

Br J Haematol ; 204(4): 1146-1158, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38296617

3.

Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase.

Jeyaraju, Danny V; Alapa, Maryam; Polonskaia, Ann; Risueño, Alberto; Subramanyam, Prakash; Anand, Amit; Ghosh, Kaushik; Kyriakopoulos, Charalampos; Hemerich, Daiane; Hurren, Rose; Wang, Xiaoming; Gronda, Marcela; Ahsan, Aarif; Chiu, Hsiling; Thomas, Geethu; Lind, Evan F; Menezes, Daniel L; Schimmer, Aaron D; Hagner, Patrick R; Gandhi, Anita; Thakurta, Anjan G.

Haematologica ; 109(4): 1082-1094, 2024 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-37941406

4.

Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8⁺ T Cell Proliferation.

Dimitriou, Ioannis D; Meiri, David; Jitkova, Yulia; Elford, Alisha R; Koritzinsky, Marianne; Schimmer, Aaron D; Ohashi, Pamela S; Sonenberg, Nahum; Rottapel, Robert.

J Immunol ; 208(12): 2702-2712, 2022 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-35667842

5.

E1 Enzymes as Therapeutic Targets in Cancer.

Barghout, Samir H; Schimmer, Aaron D.

Pharmacol Rev ; 73(1): 1-58, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-33177128

6.

Venous thromboembolism incidence associated with pegylated asparaginase (ASP) compared to the native L-ASP: A retrospective analysis with an ASP-based protocol in adult patients with acute lymphoblastic leukaemia.

Chen, RuiQi; Atenafu, Eshetu G; Seki, Jack; Liu, Xing; Chan, Steven; Gupta, Vikas; Maze, Dawn; Shuh, Andre C; Minden, Mark D; Yee, Karen; Schimmer, Aaron D; Sibai, Hassan.

Br J Haematol ; 201(4): 645-652, 2023 05.

Artículo en Inglés | MEDLINE | ID: mdl-36794878

7.

Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production.

Lee, Jong Bok; Khan, Dilshad H; Hurren, Rose; Xu, Mingjing; Na, Yoosu; Kang, Hyeonjeong; Mirali, Sara; Wang, Xiaoming; Gronda, Marcela; Jitkova, Yulia; MacLean, Neil; Arruda, Andrea; Alaniz, Zoe; Konopleva, Marina Y; Andreeff, Michael; Minden, Mark D; Zhang, Li; Schimmer, Aaron D.

Blood ; 138(3): 234-245, 2021 07 22.

Artículo en Inglés | MEDLINE | ID: mdl-34292323

8.

Very long chain fatty acid metabolism is required in acute myeloid leukemia.

Tcheng, Matthew; Roma, Alessia; Ahmed, Nawaz; Smith, Richard W; Jayanth, Preethi; Minden, Mark D; Schimmer, Aaron D; Hess, David A; Hope, Kristin; Rea, Kevin A; Akhtar, Tariq A; Bohrnsen, Eric; D'Alessandro, Angelo; Mohsen, Al-Walid; Vockley, Jerry; Spagnuolo, Paul A.

Blood ; 137(25): 3518-3532, 2021 06 24.

Artículo en Inglés | MEDLINE | ID: mdl-33720355

9.

Mitochondrial carrier homolog 2 is necessary for AML survival.

Khan, Dilshad H; Mullokandov, Michael; Wu, Yan; Voisin, Veronique; Gronda, Marcela; Hurren, Rose; Wang, Xiaoming; MacLean, Neil; Jeyaraju, Danny V; Jitkova, Yulia; Xu, G Wei; Laister, Rob; Seneviratne, Ayesh; Blatman, Zachary M; Ketela, Troy; Bader, Gary D; Marhon, Sajid A; De Carvalho, Daniel D; Minden, Mark D; Gross, Atan; Schimmer, Aaron D.

Blood ; 136(1): 81-92, 2020 07 02.

Artículo en Inglés | MEDLINE | ID: mdl-32299104

10.

A 17-gene stemness score for rapid determination of risk in acute leukaemia.

Ng, Stanley W K; Mitchell, Amanda; Kennedy, James A; Chen, Weihsu C; McLeod, Jessica; Ibrahimova, Narmin; Arruda, Andrea; Popescu, Andreea; Gupta, Vikas; Schimmer, Aaron D; Schuh, Andre C; Yee, Karen W; Bullinger, Lars; Herold, Tobias; Görlich, Dennis; Büchner, Thomas; Hiddemann, Wolfgang; Berdel, Wolfgang E; Wörmann, Bernhard; Cheok, Meyling; Preudhomme, Claude; Dombret, Herve; Metzeler, Klaus; Buske, Christian; Löwenberg, Bob; Valk, Peter J M; Zandstra, Peter W; Minden, Mark D; Dick, John E; Wang, Jean C Y.

Nature ; 540(7633): 433-437, 2016 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-27926740

11.

Measurable residual disease monitoring provides insufficient lead-time to prevent morphologic relapse in the majority of patients with core-binding factor acute myeloid leukemia.

Puckrin, Robert; Atenafu, Eshetu G; Claudio, Jaime O; Chan, Steven; Gupta, Vikas; Maze, Dawn; McNamara, Caroline; Murphy, Tracy; Shuh, Andre C; Yee, Karen; Sibai, Hassan; Minden, Mark D; Wei, Cuihong; Stockley, Tracy; Kamel-Reid, Suzanne; Schimmer, Aaron D.

Haematologica ; 106(1): 56-63, 2021 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-31896684

12.

ZDHHC21: a mitochondrial vulnerability in AML.

Schimmer, Aaron D.

Blood ; 142(4): 309-311, 2023 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-37498585

13.

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.

Shlush, Liran I; Zandi, Sasan; Mitchell, Amanda; Chen, Weihsu Claire; Brandwein, Joseph M; Gupta, Vikas; Kennedy, James A; Schimmer, Aaron D; Schuh, Andre C; Yee, Karen W; McLeod, Jessica L; Doedens, Monica; Medeiros, Jessie J F; Marke, Rene; Kim, Hyeoung Joon; Lee, Kwon; McPherson, John D; Hudson, Thomas J; Brown, Andrew M K; Yousif, Fouad; Trinh, Quang M; Stein, Lincoln D; Minden, Mark D; Wang, Jean C Y; Dick, John E.

Nature ; 506(7488): 328-33, 2014 Feb 20.

Artículo en Inglés | MEDLINE | ID: mdl-24522528

14.

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.

Liyanage, Sanduni U; Hurren, Rose; Voisin, Veronique; Bridon, Gaëlle; Wang, Xiaoming; Xu, ChangJiang; MacLean, Neil; Siriwardena, Thirushi P; Gronda, Marcela; Yehudai, Dana; Sriskanthadevan, Shrivani; Avizonis, Daina; Shamas-Din, Aisha; Minden, Mark D; Bader, Gary D; Laposa, Rebecca; Schimmer, Aaron D.

Blood ; 129(19): 2657-2666, 2017 05 11.

Artículo en Inglés | MEDLINE | ID: mdl-28283480

15.

The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase Î³, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.

Yehudai, Dana; Liyanage, Sanduni U; Hurren, Rose; Rizoska, Biljana; Albertella, Mark; Gronda, Marcela; Jeyaraju, Danny V; Wang, Xiaoming; Barghout, Samir H; MacLean, Neil; Siriwardena, Thirushi P; Jitkova, Yulia; Targett-Adams, Paul; Schimmer, Aaron D.

Haematologica ; 104(5): 963-972, 2019 05.

Artículo en Inglés | MEDLINE | ID: mdl-30573504

16.

Pain in patients with newly diagnosed or relapsed acute leukemia.

Shaulov, Adir; Rodin, Gary; Popovic, Gordana; Caraiscos, Valerie B; Le, Lisa W; Rydall, Anne; Schimmer, Aaron D; Zimmermann, Camilla.

Support Care Cancer ; 27(8): 2789-2797, 2019 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-30535882

17.

A phase II open-label study of aprepitant as anti-emetic prophylaxis in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy.

Brandwein, Joseph M; Seki, Jack T; Atenafu, Eshetu G; Rostom, Amr; Lutynski, Andrzej; Rydlewski, Anna; Schimmer, Aaron D; Schuh, Andre C; Gupta, Vikas; Yee, Karen W L.

Support Care Cancer ; 27(6): 2295-2300, 2019 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-30341536

18.

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.

Zhang, Zubin; Tong, Jiefei; Tang, Xiaowen; Juan, Jiaxiang; Cao, Biyin; Hurren, Rose; Chen, Guodong; Taylor, Paul; Xu, Xin; Shi, Chang-Xin; Du, Juan; Hou, Jian; Wang, Guanghui; Wu, Depei; Stewart, A Keith; Schimmer, Aaron D; Moran, Michael F; Mao, Xinliang.

Blood ; 127(13): 1676-86, 2016 Mar 31.

Artículo en Inglés | MEDLINE | ID: mdl-26825710

19.

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.

Sriskanthadevan, Shrivani; Jeyaraju, Danny V; Chung, Timothy E; Prabha, Swayam; Xu, Wei; Skrtic, Marko; Jhas, Bozhena; Hurren, Rose; Gronda, Marcela; Wang, Xiaoming; Jitkova, Yulia; Sukhai, Mahadeo A; Lin, Feng-Hsu; Maclean, Neil; Laister, Rob; Goard, Carolyn A; Mullen, Peter J; Xie, Stephanie; Penn, Linda Z; Rogers, Ian M; Dick, John E; Minden, Mark D; Schimmer, Aaron D.

Blood ; 125(13): 2120-30, 2015 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-25631767

20.

What doesn't kill you makes you stronger - bcl-2 promotes survival independent of proliferation.