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1.
J Infect Dis ; 219(9): 1364-1372, 2019 04 16.
Artículo en Inglés | MEDLINE | ID: mdl-30445538

RESUMEN

BACKGROUND: Noroviruses are the leading cause of acute gastroenteritis outbreaks worldwide. Clarifying the viral, host, and environmental factors (epidemiologic triad) associated with severe outcomes can help target public health interventions. METHODS: Acute norovirus outbreaks reported to the National Outbreak Reporting System (NORS) in 2009-2016 were linked to laboratory-confirmed norovirus outbreaks reported to CaliciNet. Outbreaks were analyzed for differences in genotype (GII.4 vs non-GII.4), hospitalization, and mortality rates by timing, setting, transmission mode, demographics, clinical symptoms, and health outcomes. RESULTS: A total of 3747 norovirus outbreaks were matched from NORS and CaliciNet. Multivariable models showed that GII.4 outbreaks (n = 2353) were associated with healthcare settings (odds ratio [OR], 3.94 [95% confidence interval {CI}, 2.99-5.23]), winter months (November-April; 1.55 [95% CI, 1.24-1.93]), and older age of cases (≥50% aged ≥75 years; 1.37 [95% CI, 1.04-1.79]). Severe outcomes were more likely among GII.4 outbreaks (hospitalization rate ratio [RR], 1.54 [95% CI, 1.23-1.96]; mortality RR, 2.77 [95% CI, 1.04-5.78]). Outbreaks in healthcare settings were also associated with higher hospitalization (RR, 3.22 [95% CI, 2.34-4.44]) and mortality rates (RR, 5.65 [95% CI, 1.92-18.70]). CONCLUSIONS: Severe outcomes more frequently occurred in norovirus outbreaks caused by GII.4 and those in healthcare settings. These results should help guide preventive interventions for targeted populations, including vaccine development.


Asunto(s)
Infecciones por Caliciviridae/complicaciones , Infecciones por Caliciviridae/epidemiología , Brotes de Enfermedades , Norovirus/genética , Factores de Edad , Anciano , Infecciones por Caliciviridae/mortalidad , Infecciones por Caliciviridae/transmisión , Infección Hospitalaria/epidemiología , Infección Hospitalaria/virología , Femenino , Genotipo , Instituciones de Salud/estadística & datos numéricos , Hospitalización/estadística & datos numéricos , Humanos , Masculino , Estaciones del Año , Índice de Severidad de la Enfermedad , Estados Unidos
2.
MMWR Morb Mortal Wkly Rep ; 66(7): 185-189, 2017 Feb 24.
Artículo en Inglés | MEDLINE | ID: mdl-28231235

RESUMEN

Norovirus is the leading cause of endemic and epidemic acute gastroenteritis in the United States (1). New variant strains of norovirus GII.4 emerge every 2-4 years (2-4) and are often associated with increased disease and health care visits (5-7). Since 2009, CDC has obtained epidemiologic data on norovirus outbreaks from state health departments through the National Outbreak Reporting System (NORS) (8) and laboratory data through CaliciNet (9). NORS is a web-based platform for reporting waterborne, foodborne, and enteric disease outbreaks of all etiologies, including norovirus, to CDC. CaliciNet, a nationwide electronic surveillance system of local and state public health and regulatory agency laboratories, collects genetic sequences of norovirus strains associated with gastroenteritis outbreaks. Because these two independent reporting systems contain complementary data, integration of NORS and CaliciNet records could provide valuable public health information about norovirus outbreaks. However, reporting lags and inconsistent identification codes in NORS and CaliciNet records have been an obstacle to developing an integrated surveillance system.


Asunto(s)
Infecciones por Caliciviridae/epidemiología , Brotes de Enfermedades , Gastroenteritis/epidemiología , Norovirus , Vigilancia de la Población/métodos , Humanos , Norovirus/genética , Estados Unidos/epidemiología
3.
Infect Dis Clin North Am ; 32(1): 103-118, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-29406972

RESUMEN

Norovirus is a leading cause of childhood vomiting and diarrhea in the United States and globally. Although most illnesses caused by norovirus are self-resolving, severe outcomes may occur from dehydration, including hospitalization and death. A vast majority of deaths from norovirus occur in developing countries. Immunocompromised children are at risk for more severe outcomes. Treatment of norovirus illness is focused on early correction of dehydration and maintenance of fluid status and nutrition. Hand hygiene, exclusion of ill individuals, and environmental cleaning are important for norovirus outbreak prevention and control, and vaccines to prevent norovirus illness are currently under development.


Asunto(s)
Infecciones por Caliciviridae/epidemiología , Diarrea/epidemiología , Gastroenteritis/epidemiología , Norovirus/aislamiento & purificación , Adolescente , Infecciones por Caliciviridae/mortalidad , Infecciones por Caliciviridae/prevención & control , Infecciones por Caliciviridae/virología , Niño , Preescolar , Deshidratación/diagnóstico , Deshidratación/etiología , Deshidratación/prevención & control , Países en Desarrollo/estadística & datos numéricos , Diarrea/prevención & control , Diarrea/virología , Brotes de Enfermedades/prevención & control , Brotes de Enfermedades/estadística & datos numéricos , Femenino , Enfermedades Transmitidas por los Alimentos/epidemiología , Enfermedades Transmitidas por los Alimentos/virología , Gastroenteritis/prevención & control , Gastroenteritis/virología , Hospitalización/estadística & datos numéricos , Humanos , Masculino , Estados Unidos/epidemiología , Vacunas Virales , Vómitos/epidemiología , Vómitos/etiología , Vómitos/virología
4.
PLoS One ; 13(2): e0191429, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29444124

RESUMEN

BACKGROUND: Hospitalizations for rotavirus and acute gastroenteritis (AGE) have declined in the US with rotavirus vaccination, though biennial peaks in incidence in children aged less than 5 years occur. This pattern may be explained by lower rotavirus vaccination coverage in US children (59% to 73% from 2010-2015), resulting in accumulation of susceptible children over two successive birth cohorts. METHODS: Retrospective cohort analysis of claims data of commercially insured US children aged <5 years. Age-stratified hospitalization rates for rotavirus and for AGE from the 2002-2015 rotavirus seasons were examined. Median age and rotavirus vaccination coverage for biennial rotavirus seasons during pre-vaccine (2002-2005), early post-vaccine (2008-2011) and late post-vaccine (2012-2015) years. RESULTS: Age-stratified hospitalization rates decreased from pre-vaccine to early post-vaccine and then to late post-vaccine years. The clearest biennial pattern in hospitalization rates is the early post-vaccine period, with higher rates in 2009 and 2011 than in 2008 and 2010. The pattern diminishes in the late post-vaccine period. For rotavirus hospitalizations, the median age and the difference in age between biennial seasons was highest during the early post-vaccine period; these differences were not observed for AGE hospitalizations. There was no significant difference in vaccination coverage between biennial seasons. CONCLUSIONS: These observations provide conflicting evidence that incomplete vaccine coverage drove the biennial pattern in rotavirus hospitalizations that has emerged with rotavirus vaccination in the US. As this pattern is diminishing with higher vaccine coverage in recent years, further increases in vaccine coverage may reach a threshold that eliminates peak seasons in hospitalizations.


Asunto(s)
Infecciones por Rotavirus/epidemiología , Rotavirus/inmunología , Vacunación/tendencias , Preescolar , Estudios de Cohortes , Femenino , Gastroenteritis/epidemiología , Gastroenteritis/inmunología , Gastroenteritis/virología , Hospitalización/tendencias , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Estudios Retrospectivos , Rotavirus/patogenicidad , Vacunas contra Rotavirus/inmunología , Estados Unidos , Vacunación/estadística & datos numéricos
5.
Food Saf (Tokyo) ; 6(2): 58-66, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32231948

RESUMEN

Noroviruses are the leading cause of acute gastroenteritis and foodborne disease in the United States (U.S.). About 1 in 5 reported norovirus outbreaks are spread through foodborne transmission, presenting opportunities for prevention. We describe the epidemiology of U.S. foodborne norovirus outbreaks reported to national surveillance systems, including differences between genotypes. Foodborne outbreaks that occurred during August 2009-July 2015 with norovirus reported as a single confirmed etiology to the National Outbreak Reporting System (NORS) were matched with outbreaks reported to CaliciNet, a U.S. laboratory norovirus outbreak surveillance network. We analyzed these matched outbreaks stratified by genotype for epidemiologic characteristics, including setting, size and duration, health outcomes of case-patients, implicated food, and outbreak contributing factors. Four hundred ninety-three confirmed foodborne norovirus outbreaks were reported in both NORS and CaliciNet. The most common norovirus genotypes reported were GII.4 (52%), GII.6 (9%), and GI.3 (8%). Compared to non-GII.4 outbreaks, GII.4 outbreaks had higher hospitalization rates (12.8 vs. 4.8 per 1,000 cases, P < 0.01). While contaminated foods were identified and reported in only 35% of outbreaks, molluscan shellfish (4% overall) were more often implicated in non-GII.4 outbreaks than in GII.4 outbreaks (7% vs. 1%, P = 0.04). Of the 240 outbreaks reporting at least one contributing factor, food workers were implicated as the source of contamination in 182 (76%), with no difference between GII.4 and non-GII.4 (73% vs 79%, P = 0.3). Foodborne norovirus outbreaks are frequently reported in the U.S., most of which are caused by GII.4 noroviruses. Viruses of this genotype are associated with higher rates of hospitalization; non-GII.4 noroviruses are more frequently associated with contaminated molluscan shellfish. These surveillance data highlight the diversity of noroviruses causing foodborne disease and can help guide appropriate food safety interventions, including worker hygiene, improved food handling and preparation, and further development of norovirus vaccines.

6.
J Pediatric Infect Dis Soc ; 7(1): 56-63, 2018 Feb 19.
Artículo en Inglés | MEDLINE | ID: mdl-28369477

RESUMEN

BACKGROUND: Previous studies have found a strong correlation between internet search and public health surveillance data. Less is known about how search data respond to public health interventions, such as vaccination, and the consistency of responses in different countries. In this study, we aimed to study the correlation between internet searches for "rotavirus" and rotavirus disease activity in the United States, United Kingdom, and Mexico before and after introduction of rotavirus vaccine. METHODS: We compared time series of internet searches for "rotavirus" from Google Trends with rotavirus laboratory reports from the United States and United Kingdom and with hospitalizations for acute gastroenteritis in the United States and Mexico. Using time and location parameters, Google quantifies an internet query share (IQS) to measure the relative search volume for specific terms. We analyzed the correlation between IQS and laboratory and hospitalization data before and after national vaccine introductions. RESULTS: There was a strong positive correlation between the rotavirus IQS and laboratory reports in the United States (R2 = 0.79) and United Kingdom (R2 = 0.60) and between the rotavirus IQS and acute gastroenteritis hospitalizations in the United States (R2 = 0.87) and Mexico (R2 = 0.69) (P < .0001 for all correlations). The correlations were stronger in the prevaccine period than in the postvaccine period. After vaccine introduction, the mean rotavirus IQS decreased by 40% (95% confidence interval [CI], 25%-55%) in the United States and by 70% (95% CI, 55%-86%) in Mexico. In the United Kingdom, there was a loss of seasonal variation after vaccine introduction. CONCLUSIONS: Rotavirus internet search data trends mirrored national rotavirus laboratory trends in the United States and United Kingdom and gastroenteritis-hospitalization data in the United States and Mexico; lower correlations were found after rotavirus vaccine introduction.


Asunto(s)
Internet/estadística & datos numéricos , Infecciones por Rotavirus/epidemiología , Vacunas contra Rotavirus/uso terapéutico , Preescolar , Gastroenteritis/epidemiología , Hospitalización/estadística & datos numéricos , Humanos , Conducta en la Búsqueda de Información , México/epidemiología , Infecciones por Rotavirus/prevención & control , Estaciones del Año , Reino Unido/epidemiología , Estados Unidos/epidemiología
7.
Expert Rev Vaccines ; 16(10): 987-995, 2017 10.
Artículo en Inglés | MEDLINE | ID: mdl-28832219

RESUMEN

INTRODUCTION: Rotavirus is the leading cause of hospitalizations and deaths from diarrhea. 33 African countries had introduced rotavirus vaccines by 2016. We estimate reductions in rotavirus hospitalizations and deaths for countries using rotavirus vaccination in national immunization programs and the potential of vaccine introduction across the continent. Areas covered: Regional rotavirus burden data were reviewed to calculate hospitalization rates, and applied to under-5 population to estimate baseline hospitalizations. Rotavirus mortality was based on 2013 WHO estimates. Regional pre-licensure vaccine efficacy and post-introduction vaccine effectiveness studies were used to estimate summary effectiveness, and vaccine coverage was applied to calculate prevented hospitalizations and deaths. Uncertainties around input parameters were propagated using boot-strapping simulations. In 29 African countries that introduced rotavirus vaccination prior to end 2014, 134,714 (IQR 112,321-154,654) hospitalizations and 20,986 (IQR 18,924-22,822) deaths were prevented in 2016. If all African countries had introduced rotavirus vaccines at benchmark immunization coverage, 273,619 (47%) (IQR 227,260-318,102) hospitalizations and 47,741 (39%) (IQR 42,822-52,462) deaths would have been prevented. Expert commentary: Rotavirus vaccination has substantially reduced hospitalizations and deaths in Africa; further reductions are anticipated as additional countries implement vaccination. These estimates bolster wider introduction and continued support of rotavirus vaccination programs.


Asunto(s)
Diarrea/prevención & control , Hospitalización/estadística & datos numéricos , Infecciones por Rotavirus/prevención & control , Vacunas contra Rotavirus/administración & dosificación , Rotavirus/inmunología , Vacunación/estadística & datos numéricos , África/epidemiología , Preescolar , Diarrea/inmunología , Diarrea/mortalidad , Diarrea/virología , Humanos , Programas de Inmunización/organización & administración , Lactante , Recién Nacido , Infecciones por Rotavirus/inmunología , Infecciones por Rotavirus/mortalidad , Infecciones por Rotavirus/virología , Análisis de Supervivencia
8.
Pediatr Infect Dis J ; 35(7): 782-6, 2016 07.
Artículo en Inglés | MEDLINE | ID: mdl-27088585

RESUMEN

BACKGROUND: Rotavirus vaccination of all infants began in the United States in 2006. Although the effect of vaccination on childhood hospitalizations for rotavirus has been well described, the effects of rotavirus vaccine on emergency department (ED) visits are less well documented. METHODS: Using the State Emergency Department Databases for 10 US states, we compared the rates of gastroenteritis- and rotavirus-coded ED visits among children <5 years of age in prevaccine (2003 to 2006) with those in postvaccine (2008-2013) years; 2007 was excluded as a transition year. We analyzed ED visit rates by age group, sex, race and rotavirus season. RESULTS: The prevaccine annual gastroenteritis-coded ED visit rate among children <5 years of age of 426 per 10,000 (annual range, 396-477 per 10,000) declined to 382 per 10,000 in postvaccine years, a 10.3% (±0.3%, P < 0.0001) rate reduction overall. Compared with prevaccine years, annual ED visit rates for gastroenteritis decreased by 6.5% (±0.6%) in 2008, 12.3% (±0.6%) in 2010, 14.8% (±0.5%) in 2011, 20.4% (±0.5%) in 2012 and 10.1% (±0.6%) in 2013; a small increase of 1.8% (±0.6%) was seen in 2009 (P < 0.0001 for all individual comparisons). Declines were similar by sex and race and were greater in children <2 years of age (range 14.1%-20.6%, P < 0.0001) than in older children (increase of 3.3% ±0.6%, P < 0.0001). A decline of 21.2% (±0.4%, P < 0.0001) in ED visits was seen during the rotavirus season months from January through June versus an increase of 9.5% (±0.6%, P < 0.0001) during July to December. ED visits specifically coded for rotavirus showed more prominent declines than for all gastroenteritis. CONCLUSIONS: ED visits for gastroenteritis in US children have declined since the introduction of rotavirus vaccine.


Asunto(s)
Servicio de Urgencia en Hospital/estadística & datos numéricos , Gastroenteritis/prevención & control , Gastroenteritis/terapia , Hospitalización/estadística & datos numéricos , Infecciones por Rotavirus/prevención & control , Infecciones por Rotavirus/terapia , Vacunas contra Rotavirus/administración & dosificación , Preescolar , Bases de Datos Factuales , Diarrea/virología , Femenino , Gastroenteritis/epidemiología , Gastroenteritis/virología , Humanos , Programas de Inmunización , Inmunización Secundaria , Lactante , Recién Nacido , Masculino , Rotavirus/inmunología , Infecciones por Rotavirus/epidemiología , Infecciones por Rotavirus/virología , Vacunas contra Rotavirus/efectos adversos , Estaciones del Año , Resultado del Tratamiento , Estados Unidos/epidemiología
9.
J Health Care Poor Underserved ; 20(4): 1049-59, 2009 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20168017

RESUMEN

OBJECTIVE: We examined the impact of arrest and incarceration on primary care patients in the Bronx, New York. METHODS: Patients at three clinics were asked eight questions concerning current and past involvement in criminal proceedings, arrest, and incarceration. RESULTS: One hundred eighteen patients were surveyed. Eleven (9%) patients were currently involved in criminal proceedings. Twenty-one (18%) currently had a family member in jail or prison. Twenty-nine (25%) reported ever being arrested; 65 (55%) reported that they or a family member had been arrested. Twenty-one (18%) had been incarcerated; 60 (51%) reported they or a family member had spent time in jail or prison. For most variables, rates were higher for men and the adults accompanying children at pediatric visits. Clinicians reported positive experiences discussing incarceration. CONCLUSIONS: Involvement with the criminal justice system was common among our patients. Discussion of incarceration did not appear to have a negative impact on the clinical relationship.


Asunto(s)
Actitud Frente a la Salud , Salud de la Familia , Pacientes Ambulatorios/legislación & jurisprudencia , Atención Primaria de Salud , Prisioneros/estadística & datos numéricos , Adulto , Atención Ambulatoria , Recolección de Datos , Femenino , Humanos , Aplicación de la Ley , Masculino , New York , Pacientes Ambulatorios/psicología , Relaciones Profesional-Paciente , Factores Sexuales , Salud Urbana
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