1.
Bioorg Med Chem Lett
; 23(19): 5264-6, 2013 Oct 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23988351
RESUMEN
A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines.
Asunto(s)
Antineoplásicos/síntesis química , Compuestos Aza/síntesis química , Fluorenos/síntesis química , Antineoplásicos/química , Antineoplásicos/farmacología , Compuestos Aza/química , Derivados del Benceno/síntesis química , Derivados del Benceno/química , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Estructura Molecular
2.
Bioorg Med Chem Lett
; 23(6): 1846-52, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23395656
RESUMEN
A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested.