[Pathogenetic mechanisms of the development of cardiac rhythm disorders in the acute period of myocardial infarction]. / Patogeneticheskie mekhanizmy razvitiia narushenii ritma serdtsa v ostrom periode infarkta miokarda.

The clinical course and biochemical, radioimmune and electrophysiologic findings were assessed in 421 patients with acute myocardial infarction involving heart rhythm and conductivity disorders and 49 patients with acute myocardial infarction, free of cardiac electrical instability. The studies were carried out during arrhythmias and after they were controlled, prior to treatment, at the peak of antiarrhythmic effect of medication, and after a continuous treatment course. Heart rhythm disorders related to acute myocardial infarction were accompanied with a marked response on the part of blood free fatty acids, sympatho-adrenal and kallikrein-kinin activity and carboxycathepsin. Metabolic and neurohumoral changes were eventually reversed and tended to normalize as soon as the sinus rhythm was restored by treatment.

[The efficacy of prolonged-action nitrates in stenocardia]. / Effektivnost' nitratov prolongirovannogo deistviia pri stenokardii.

The therapeutic efficacy and changes of clinical and hemodynamic indices due to the use of long-action nitrates were studied in 91 patients with chronic ischemic heart disease. The native drug nitrogranulong produces an essential effect on the hemodynamics resulting in a complete disappearance or reduction of stenocardia attacks, increased tolerance to physical loads as evidenced by bicycle ergometric data.