Investigations on physiochemical and biomedical properties of Aloe vera - Sterculia gum copolymeric dressings impregnated with antibiotic-anesthetic drugs to enhance wound healing.

Recently, various innovative advancements have been made in carbohydrate research to design versatile materials for biomedical applications. The current research focuses on the development of copolymeric hydrogel wound dressings (HWD) using a combination of aloe vera (AV) - sterculia gum (SG) - poly (vinylsulfonic acid) (VSA)-based with the aim to enhancing their efficacy in drug delivery (DD) applications. These hydrogel dressings were encapsulated with levofloxacin and lidocaine to address both microbial infection and pain. Copolymers were characterized by FESEM, SEM, EDS, AFM, 13C NMR, FTIR, XRD, and TGA-DTG analysis. Hydrogel exhibited a fluid absorption capacity of 4.52 ± 0.12 g per gram of polymeric dressing in simulated wound conditions. The hydrogels displayed a sustained release of drugs, demonstrating a non-Fickian diffusion mechanism. Polymer dressings revealed antibacterial, mucoadhesive, antioxidant, biocompatible and non-cytotoxic properties. Additionally, HWD displayed permeability to O2 and water vapour, yet was impermeable to microbial penetration. Overall, the findings of physiological, biochemical and drug delivery properties demonstrated the suitability of materials for wound dressing applications.

Fabricating gum polysaccharides based nano-composites for drug delivery uses via sustainable green approach.

Recent advancements in development of natural polymer nono-composites led to exploration of potential of gum acacia (GA) and tragacanth gum (TG) for design of silver nanoparticles (AgNPs) impregnated grafted copolymers via green approach for use in drug delivery (DD). The formation of copolymers was confirmed by UV-Vis spectroscopy, TEM, SEM, AFM, XPS, XRD, FTIR,TGA and DSC. UV-Vis spectra indicated the formation of AgNPs using GA as reducing agent. TEM, SEM, XPS and XRD revealed impregnation of AgNPs inside the copolymeric network hydrogels. TGA inferred thermal stability of polymer enhanced by grafting and incorporation of AgNPs. The non-Fickian diffusion of antibiotic drug meropenem was revealed from drug encapsulated GA-TG-(AgNPs)-cl-poly(AAm) network which were also pH responsive and release profile was fitted in Korsmeyer-Peppas kinetic model. Sustained release was due to polymer-drug interaction. The polymer-blood interaction demonstrated biocompatible characteristics of polymer. Mucoadhesive property exhibited by copolymers because of supra-molecular interactions. Antimicrobial characteristics were shown by copolymers against bacteria S. flexneri, P. auroginosa, and B. cereus.

Synthesis and characterization of modified bioactive arabinoxylan-psyllium: Evaluation of molecular interactions, physiochemical and biomedical properties.

Keeping in view the future prospectus of carbohydrate polymers, present research report is an elaboration, exploration and execution of the research expectancy in area of these polymers by researchers like John F. Kennedy. Herein, molecular interactions and physiochemical properties of modified bioactive arabinoxylan-psyllium have been evaluated for drug delivery applications. Arabinoxylan-psyllium was modified with sulphated and amide copolymers and co-polymers were characterized by SEMs, AFM, FTIR, XRD, solid state 13C NMR, TGA-DSC and water absorption studies. The 13C-NMR and FTIR confirmed grafted copolymers. The polymer-blood interactions revealed non-thrombogenic nature with thrombose percentage 63.17 ± 5.61 % and polymer-mucous membrane interactions showed detachment force 0.237 ± 0.078Nwith bio-membrane in mucoadhesion test. The pH responsible gels exhibited 44.49 ± 3.12 % inhibitions of free radicals in DPPH assay. The polymer-drug interactions demonstrated sustained diffusion of methotrexate with non-Fickian diffusion and Korsmeyer-Peppas kinetic model. Overall, co-polymeric network structure was found useful in colon specific drug delivery.