SARS-CoV-2 VOCs, Mutational diversity and clinical outcome: Are they modulating drug efficacy by altered binding strength?

The global COVID-19 pandemic continues due to emerging Severe Acute Respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC). Here, we performed comprehensive analysis of in-house sequenced SARS-CoV-2 genome mutations dynamics in the patients infected with the VOCs - Delta and Omicron, within Recovered and Mortality patients. Statistical analysis highlighted significant mutations - T4685A, N4992N, and G5063S in RdRp; T19R in NTD spike; K444N and N532H in RBD spike, associated with Delta mortality. Mutations, T19I in NTD spike, Q493R and N440K in the RBD spike were significantly associated with Omicron mortality. We performed molecular docking for possible effect of significant mutations on the binding of Remdesivir. We found that Remdesivir showed less binding efficacy with the mutant Spike protein of both Delta and Omicron mortality compared to recovered patients. This indicates that mortality associated mutations could have a modulatory effect on drug binding which could be associated with disease outcome.

BSEMS-A Blockchain-Based Smart Energy Measurement System.

The modern world's increasing reliance on automated systems for everyday tasks has resulted in a corresponding rise in power consumption. The demand is further augmented by increased sales of electric vehicles, smart cities, smart transportation, etc. This growing dependence underscores the critical necessity for a robust smart energy measurement and management system to ensure a continuous and efficient power supply. However, implementing such a system presents a set of challenges, particularly concerning the transparency, security, and trustworthiness of data storage and retrieval. Blockchain technology offers an innovative solution in the form of a distributed ledger, which guarantees secure and transparent transaction storage and retrieval. This research introduces a blockchain-based system, utilising Hyperledger Fabric and smart contracts, designed for the secure storage and retrieval of consumers' energy consumption data. Finally, a user-friendly web portal was designed and developed using the node.js framework, offering an accessible and intuitive interface to monitor and manage energy consumption effectively.

Adaptation of IoT with Blockchain in Food Supply Chain Management: An Analysis-Based Review in Development, Benefits and Potential Applications.

In today's scenario, blockchain technology is an emerging area and promising technology in the field of the food supply chain industry (FSCI). A literature survey comprising an analytical review of blockchain technology with the Internet of things (IoT) for food supply chain management (FSCM) is presented to better understand the associated research benefits, issues, and challenges. At present, with the concept of farm-to-fork gaining increasing popularity, food safety and quality certification are of critical concern. Blockchain technology provides the traceability of food supply from the source, i.e., the seeding factories, to the customer's table. The main idea of this paper is to identify blockchain technology with the Internet of things (IoT) devices to investigate the food conditions and various issues faced by transporters while supplying fresh food. Blockchain provides applications such as smart contracts to monitor, observe, and manage all transactions and communications among stakeholders. IoT technology provides approaches for verifying all transactions; these transactions are recorded and then stored in a centralized database system. Thus, IoT enables a safe and cost-effective FSCM system for stakeholders. In this paper, we contribute to the awareness of blockchain applications that are relevant to the food supply chain (FSC), and we present an analysis of the literature on relevant blockchain applications which has been conducted concerning various parameters. The observations in the present survey are also relevant to the application of blockchain technology with IoT in other areas.

A Survey on Applications of Artificial Intelligence for Pre-Parametric Project Cost and Soil Shear-Strength Estimation in Construction and Geotechnical Engineering.

Ensuring soil strength, as well as preliminary construction cost and duration prediction, is a very crucial and preliminary aspect of any construction project. Similarly, building strong structures is very important in geotechnical engineering to ensure the bearing capability of structures against external forces. Hence, in this first-of-its-kind state-of-the-art review, the capability of various artificial intelligence (AI)-based models toward accurate prediction and estimation of preliminary construction cost, duration, and shear strength is explored. Initially, background regarding the revolutionary AI technology along with its different models suited for geotechnical and construction engineering is presented. Various existing works in the literature on the usage of AI-based models for the abovementioned applications of construction and maintenance are presented along with their advantages, limitations, and future work. Through analysis, various crucial input parameters with great impact on the estimation of preliminary construction cost, duration, and soil shear strength are enumerated and presented. Lastly, various challenges in using AI-based models for accurate predictions in these applications, as well as factors contributing to the cost-overrun issues, are presented. This study can, thus, greatly assist civil engineers in efficiently using the capabilities of AI for solving complex and risk-sensitive tasks, and it can also be used in Internet of things (IoT) environments for automated applications such as smart structural health-monitoring systems.

Multi-scale self-attention approach for analysing motor imagery signals in brain-computer interfaces.

BACKGROUND: Motor imagery-based electroencephalogram (EEG) brain-computer interface (BCI) technology has seen tremendous advancements in the past several years. Deep learning has outperformed more traditional approaches, such next-gen neuro-technologies, in terms of productivity. It is still challenging to develop and train an end-to-end network that can sufficiently extract the possible characteristics from EEG data used in motor imaging. Brain-computer interface research is largely reliant on the fundamental problem of accurately classifying EEG data. There are still many challenges in the field of MI classification even after researchers have proposed a variety of methods, such as deep learning and machine learning techniques. METHODOLOGY: We provide a model for four-class categorization of motor imagery EEG signals using attention mechanisms: left hand, right hand, foot, and tongue/rest. The model is built on multi-scale spatiotemporal self-attention networks. To determine the most effective channels, self-attention networks are implemented spatially to assign greater weight to channels associated with motion and lesser weight to channels unrelated to motion. To eliminate noise in the temporal domain, parallel multi-scale Temporal Convolutional Network (TCN) layers are utilized to extract temporal domain features at various scales. RESULT: On the IV-2b dataset from the BCI Competition, the suggested model achieved an accuracy of 85.09 %; on the IV-2a and IV-2b datasets from the HGD datasets, it was 96.26 %. COMPARISON WITH EXISTING METHODS: In single-subject classification, this approach demonstrates superior accuracy when compared to existing methods. CONCLUSION: The findings suggest that this approach exhibits commendable performance, resilience, and capacity for transfer learning.

An IoMT-Based Approach for Real-Time Monitoring Using Wearable Neuro-Sensors.

The Internet of Things (IoT) has demonstrated over the past few decades to be a powerful tool for connecting various medical equipment with in-built sensors and healthcare professionals to deliver superior health services that also reach remote areas. In addition to reducing healthcare costs, increasing access to clinical services, and enhancing operational effectiveness in the healthcare industry, it has also enhanced patient health safety. Recent research has focused on using EEG to assist and comprehend brain changes in rehabilitation facilities. These technologies can spot fluctuations in EEG constraints during treatment, which could result in more effective therapy and better functional outcomes. As a result, we have tried to use an IoT-based system for real-time monitoring of the constraints. Another unknown patient who is suffering from acute ischemic stroke may experience stroke-in-evolution or an early worsening of neurological symptoms, which is frequently associated with poor clinical outcomes. Because of this, managing an acute stroke requires early detection of these indications. The present investigation work will act as a standard reference for academic researchers, medical professionals, and everyone else involved in the use of IoMT. This study aims to anticipate strokes sooner and prevent their consequences by early intervention using an Internet of Things (IoT)-based system. Also, this study proposes usage of wearable equipment that can monitor and analyze brain signals for improved treatment and the prevention of stroke-related complications.

COVID-19: Challenges and its Technological Solutions using IoT.

COVID-19 is a global pandemic that has affected many countries in a short span of time. People worldwide are susceptible to this deadly disease. To control the prevailing havoc of coronavirus, researchers are adopting techniques like plasma therapy, proning, medicines, etc. To stop the rapid spread of COVID-19, contact tracing is one of the important ways to check the infected people. This paper explains the various challenges people and health practitioners are facing due to COVID-19. In this paper, various ways with which the impact of COVID-19 can be controlled using IoT technology have been discussed. A six-layer architecture of IoT solutions for containing the deadly COVID-19 has been proposed. In addition to this, the role of machine learning techniques for diagnosing COVID-19 has been discussed in this paper, and a quick explanation of the unmanned aerial vehicle (UAVs) applications for contact tracing has also been specified. From the study conducted, it is evident that IoT solutions can be used in various ways for restricting the impact of COVID-19. Furthermore, IoT can be used in the healthcare sector to assure people's safety and good health with minimal costs.

Automated Bacterial Classifications Using Machine Learning Based Computational Techniques: Architectures, Challenges and Open Research Issues.

Bacteria are important in a variety of practical domains, including industry, agriculture, medicine etc. A very few species of bacteria are favourable to humans. Whereas, majority of them are extremely dangerous and causes variety of life threatening illness to different living organisms. Traditionally, this class of microbes is detected and classified using different approaches like gram staining, biochemical testing, motility testing etc. However with the availability of large amount of data and technical advances in the field of medical and computer science, the machine learning methods have been widely used and have shown tremendous performance in automatic detection of bacteria. The inclusion of latest technology employing different Artificial Intelligence techniques are greatly assisting microbiologist in solving extremely complex problems in this domain. This paper presents a review of the literature on various machine learning approaches that have been used to classify bacteria, for the period 1998-2020. The resources include research papers and book chapters from different publishers of national and international repute such as Elsevier, Springer, IEEE, PLOS, etc. The study carried out a detailed and critical analysis of penetrating different Machine learning methodologies in the field of bacterial classification along with their limitations and future scope. In addition, different opportunities and challenges in implementing these techniques in the concerned field are also presented to provide a deep insight to the researchers working in this field.

Machine Learning and Deep Learning Based Computational Approaches in Automatic Microorganisms Image Recognition: Methodologies, Challenges, and Developments.

Microorganisms or microbes comprise majority of the diversity on earth and are extremely important to human life. They are also integral to processes in the ecosystem. The process of their recognition is highly tedious, but very much essential in microbiology to carry out different experimentation. To overcome certain challenges, machine learning techniques assist microbiologists in automating the entire process. This paper presents a systematic review of research done using machine learning (ML) and deep leaning techniques in image recognition of different microorganisms. This review investigates certain research questions to analyze the studies concerning image pre-processing, feature extraction, classification techniques, evaluation measures, methodological limitations and technical development over a period of time. In addition to this, this paper also addresses the certain challenges faced by researchers in this field. Total of 100 research publications in the chronological order of their appearance have been considered for the time period 1995-2021. This review will be extremely beneficial to the researchers due to the detailed analysis of different methodologies and comprehensive overview of effectiveness of different ML techniques being applied in microorganism image recognition field.

Impact of Healthcare on Stock Market Volatility and Its Predictive Solution Using Improved Neural Network.

The unprecedented Corona Virus Disease (COVID-19) pandemic has put the world in peril and shifted global landscape in unanticipated ways. The SARSCoV2 virus, which caused the COVID-19 outbreak, first appeared in Wuhan, Hubei Province, China, in December 2019 and quickly spread around the world. This pandemic is not only a global health crisis, but it has caused the major global economic depression. As soon as the virus spread, stock market prices plummeted and volatility increased. Predicting the market during this outbreak has been of substantial importance and is the primary motivation to carry out this work. Given the nonlinearity and dynamic nature of stock data, the prediction of stock market is a challenging task. The machine learning models have proven to be a good choice for the development of effective and efficient prediction systems. In recent years, the application of hyperparameter optimization techniques for the development of highly accurate models has increased significantly. In this study, a customized neural network model is proposed and the power of hyperparameter optimization in modelling stock index prices is explored. A novel dataset is generated using nine standard technical indicators and COVID-19 data. In addition, the primary focus is on the importance of selection of optimal features and their preprocessing. The utilization of multiple feature ranking techniques combined with extensive hyperparameter optimization procedures is comprehensive for the prediction of stock index prices. Moreover, the model is evaluated by comparing it with other models, and results indicate that the proposed model outperforms other models. Given the detailed design methodology, preprocessing, exploratory feature analysis, and hyperparameter optimization procedures, this work gives a significant contribution to stock analysis research community during this pandemic.

The debate around the access to vaccine and licensing amidst second wave of COVID-19 in India.

The guardian of global health signified a "global response" to contain COVID 19 utilising the platform of World Health Organization when the novel virus strain was spreading. The nature of "waves," that is, variable epidemiological patterns and peaks in trajectory, have been inconsistent and myriad in different regions and countries. Many researchers and scholars have deliberated on the possible ways forward to curb or mitigate the effects of the virus; and one such means is through universal vaccination. Hence, this article explores the positions to achieve that goal by looking at the licensing aspect and IP waiver debate and suggests a fine-tuning which balances all the interests, amidst the second wave in India.