[The comparative action of isoniazid, rifampicin and ethambutol on liver function]. / Sravnitel'noe deistvie izoniazida, rifampitsina i étambutola na funktsional'noe sostoianie pecheni.

It has been established in experiments on white rats that antituberculous drugs (isoniazid, rifampicin, ethambutol) given in toxic doses affect the liver, its membranes and organelles, inhibit bile production and bioenergy. This is supported by activation of aspartate and alanine aminotransferases, (ALT and AST), alkaline phosphatase in blood serum and acid phosphatase in the liver, by a decrease of the activity of Na(+)-, K(+)-ATPase, succinate dehydrogenase and cytochromoxidase in the liver, lowering of the rate of bile secretion, excretion of bile acids, bilirubin and cholesterol with bile. Provided the drugs are administered in combination, the hepatotoxicity rises, particularly in combination of isoniazid with rifampicin, and especially as isoniazid is combined with rifampicin and ethambutol.

[The correction of the hepatotoxicity of antitubercular preparations with tocopherol acetate and riboxin]. / Korrektsiia gepatotoksichnosti protivotuberkuleznykh preparatov tokoferola atsetatom i riboksinom.

It has been established in experiments on white rats that prolonged (for 2 weeks) intoxication with antituberculous drugs (isoniazid plus rifampicin plus pyrazinamide) results in cytolytic liver injury. This manifests by hyperaminotransferasemia, initiation of lipid peroxidation, suppression of the antioxidant system and bile production. Daily injections of tocopherol acetate (15 mg/kg) and riboxine (100 mg/kg) together with administration of antituberculous drugs reduce their hepatotoxicity. The combined use of these hepatoprotectors and antioxidants provides a dramatic increase of their efficacy in durable intoxication with antituberculous drugs.

[The efficacy of vitogepat and sirepar in combination with karsil in chronic liver lesions]. / Effektivnost' vitogepata i sirepara v sochetanii s karsilom pri khronicheskom porazhenii pecheni.

It has been shown in experiments on white rats that chronic (for one month) intoxication with CCl4 and C2H5OH results in liver injury. It manifests by activation of aminotransferases (ALT, AST) and alkaline phosphatase in blood serum, initiation of lipid peroxidation, depletion of the liver pool of reduced glutathione, and suppression of bile production. The liver preparations (sirepar and vitohepat) reduce hepatotoxicity of the poisons in question. The use of vitohepat and sirepar in combination with carsil potentiated hepatoprotective and antioxidative activity of the liver preparations.

[Effect of enteric oxygen therapy and vitamin E on the secretion and chemical composition of bile in experimental dystrophy]. / Vliianie énteral'noi oksigenoterapii i vitamina E na sekretsiiu i khimicheskii sostav zhelchi pri éksperimental'noi distrofii.

Effects of enteral oxygenotherapy and vitamin E were studied using rats with acute liver dystrophy caused by CCl4. The enteral oxygenotherapy with simultaneous administration of vitamin E were shown to accelerate the restoration of liver function, to improve the bile formation and secretion, to stimulate the synthesis of initial biliary acids as well as to increase the conjugation of the acids with glycine and taurine, to increase the stabilizing properties of bile.

[Effectiveness of vitamin E and sodium selenate in carbon tetrachloride-induced liver damage depending on the season]. / Effektiveness vitamina E i selenita natriia pri porazhenii pecheni chetyrekhkhloristym uglerodom v zavisimosti ot sezona goda.

Seasonal features of the efficacy of antioxidants for liver poisoning with carbon tetrachloride (CCl4) were revealed in 175 random-bred male rats. Liver function was appraised according to the bile secretion characteristics (bile secretion rate, the level of bile acids, cholesterol and bilirubin in bile). It was discovered that CCl4 hepatotoxicity was the highest during spring and summer. Vitamin D was more efficacious in spring and summer, whereas sodium selenite in autumn and winter. The use of combined vitamin E and sodium selenite prevered the toxic action of CCl4 on the liver in autumn, winter and spring and minimized it in summer. The mechanisms of seasonal differences in the action of CCl4 on the liver and antioxidant efficacy for damage in question are discussed. The conclusion was made about an important role of the time factor in the prophylaxis and treatment with antioxidants of liver toxic damages.