PECULIARITIES OF THYROID STATUS OF PRESCHOOL CHILDREN WITH ACUTE BRONCHITIS.

OBJECTIVE: The aim: The aim of this study was to determine the characteristics of thyroid status (thyroid hormone, total and free fractions of triiodothyronine and thyroxine, reversible triiodothyronine, antibodies to thyroperoxidase) of preschool children with acute bronchitis. PATIENTS AND METHODS: Materials and methods: We examined 135 preschool children (from 3 to 6 years old) with acute bronchitis (main group) and 28 apparently healthy subjects who were in the control group. It used clinical-anamnestic, laboratory and instrumental research methods. Evaluation of the course of acute bronchitis was carried out in the acute period of the disease. All results were statistically processed using the SPSS 26 package. RESULTS: Results: In 33 % of patients with acute bronchitis there are subclinical abnormalities of thyroid hormones, which manifest themselves in the form of euthyroid sick syndrome. Namely, we found an increased concentration of reversible triiodothyronine in the serum, as well as a decrease in total triiodothyronine and its free fraction. CONCLUSION: Conclusions: In patients with acute bronchitis in almost every third case there are functional shifts in hormonal status, which are manifested in the form of the first variant of the euthyroid sick syndrome.

Influence of magnesium on the state of the cardiovascular system in children with chronic tonsilitis.

OBJECTIVE: The aim of the study was to evaluate the condition of the cardiovascular system and the effect of the combined preparation of magnesium and vitamin B6 in children with secondary cardiomyopathy on the background of chronic tonsillitis. PATIENTS AND METHODS: Materials and methods: 100 children at the aged of 13-17 years were surveyed, including 60 patients with secondary cardiomyopathy with chronic tonsillitis. And the group I consisted of 45 children receiving standard treatment, group II - 15 patients who, along with standard treatment, received the drug magnesium. The control group consisted of 40 healthy children. To assess the condition of the cardiovascular system and vegetative regulation, we performed electrocardiographic examination (ECG), exercise test and ECG control, cardiointervalography with clinoortostatic test. The concentration of magnesium in the serum was determined by atomic absorption spectrophotometry. Also, we have provided the requirements of the principles of bioethics and drafted a protocol in accordance with the basic principles of the Helsinki Declaration. RESULTS: Results: In addition to the standard treatment of children with magnesium drug, there was a significant decrease in the frequency of sinus arrhythmias, disorders of the intraventricular conduction, and the processes of repolarization, extrasystole, sinus suchchardia were not observed in any of the patients. The normalization of magnesium in the serum of patients was observed. CONCLUSION: Conclusions: Supplementation of combination therapy with magnesium and B6 helped to improve myocardial electrophysiology and cardiac output, as well as to normalize the serum magnesium in children with secondary cardiomyopathy.