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1.
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma.
Br J Cancer
; 118(6): 793-801, 2018 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29438372
2.
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
EMBO J
; 30(13): 2719-33, 2011 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-21602788
3.
Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.
Mol Cancer Ther
; 8(2): 324-32, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19174555
4.
Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.
J Med Chem
; 51(2): 183-6, 2008 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-18163548
5.
3'-Deoxy-3'-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models.
Mol Imaging Biol
; 20(2): 194-199, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28971330
6.
Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using 18F-ICMT-11 and 18F-FLT PET.
J Nucl Med
; 59(10): 1558-1565, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29794225
7.
Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.
J Nucl Med
; 59(7): 1063-1069, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29476002
8.
Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.
Mol Imaging Biol
; 19(4): 540-549, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27798786
9.
Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.
EJNMMI Res
; 7(1): 99, 2017 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29247446
10.
Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.
Cancer Res
; 76(24): 7096-7105, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27784748
11.
The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.
EJNMMI Res
; 6(1): 63, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27515446
12.
Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-¹8F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.
J Nucl Med
; 55(6): 983-8, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24777288
13.
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
Cancer Chemother Pharmacol
; 68(5): 1243-53, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21431415
14.
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
J Med Chem
; 53(16): 5956-69, 2010 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20662534
15.
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
J Med Chem
; 51(16): 4986-99, 2008 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18656911
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