RESUMEN
Ruthenium(II) complexes feature prominently in the development of agents for photoactivated chemotherapy; however, the excited-state mechanisms by which photochemical ligand release operates remain unclear. We report here a systematic experimental and computational study of a series of complexes [Ru(bpy)2(Nâ§N)]2+ (bpy = 2,2'-bipyridyl; Nâ§N = bpy (1), 6-methyl-2,2'-bipyridyl (2), 6,6'-dimethyl-2,2'-bipyridyl (3), 1-benzyl-4-(pyrid-2-yl)-1,2,3-triazole (4), 1-benzyl-4-(6-methylpyrid-2-yl)-1,2,3-triazole (5), 1,1'-dibenzyl-4,4'-bi-1,2,3-triazolyl (6)), in which we probe the contribution to the promotion of photochemical Nâ§N ligand release of the introduction of sterically encumbering methyl substituents and the electronic effect of replacement of pyridine by 1,2,3-triazole donors in the Nâ§N ligand. Complexes 2 to 6 all release the ligand Nâ§N on irradiation in acetonitrile solution to yield cis-[Ru(bpy)2(NCMe)2]2+, with resultant photorelease quantum yields that at first seem counter-intuitive and span a broad range. The data show that incorporation of a single sterically encumbering methyl substituent on the Nâ§N ligand (2 and 5) leads to a significantly enhanced rate of triplet metal-to-ligand charge-transfer (3MLCT) state deactivation but with little promotion of photoreactivity, whereas replacement of pyridine by triazole donors (4 and 6) leads to a similar rate of 3MLCT deactivation but with much greater photochemical reactivity. The data reported here, discussed in conjunction with previously reported data on related complexes, suggest that monomethylation in 2 and 5 sterically inhibits the formation of a 3MCcis state but promotes the population of 3MCtrans states which rapidly deactivate 3MLCT states and are prone to mediating ground-state recovery. On the other hand, increased photochemical reactivity in 4 and 6 seems to stem from the accessibility of 3MCcis states. The data provide important insights into the excited-state mechanism of photochemical ligand release by Ru(II) tris-bidentate complexes.
Asunto(s)
Compuestos Organometálicos , Rutenio , Ligandos , Teoría Cuántica , Compuestos Organometálicos/química , Rutenio/química , TriazolesRESUMEN
A complete mechanistic picture for the photochemical release of bipyridine (bpy) from the archetypal complex [Ru(bpy)3]2+ is presented for the first time following the description of the ground and lowest triplet potential energy surfaces, as well as their key crossing points, involved in successive elementary steps along pathways toward cis- and trans-[Ru(bpy)2(NCMe)2]2+. This work accounts for two main pathways that are identified involving (a) two successive photochemical reactions for photodechelation, followed by the photorelease of a monodentate bpy ligand, and (b) a novel one-photon mechanism in which the initial photoexcitation is followed by dechelation, solvent coordination, and bpy release processes, all of which occur sequentially within the triplet excited-state manifold before the final relaxation to the singlet state and formation of the final photoproducts. For the reaction between photoexcited [Ru(bpy)3]2+ and acetonitrile, which is taken as a model reaction, pathways toward cis and trans photoproducts are uphill processes, in line with the comparative inertness of the complex in this solvent. Factors involving the nature of the departing ligand and retained "spectator" ligands are considered, and their role in the selection of mechanistic pathways involving overall two sequential photon absorptions versus one photon absorption for the formation of both cis or trans photoproducts is discussed in relation to notable examples from the literature. This study ultimately provides a generalized roadmap of accessible photoproductive pathways for light-induced reactivity mechanisms of photolabile [Ru(N^N)(N^N')(N^Nâ³)]2+-type complexes.
RESUMEN
We have identified a new 3MC state bearing two elongated Ru-N bonds to the same ligand in [Ru(bpy)3]2+. This DFT-optimized structure is a local minimum on the 3PES. This distal MC state (3MCcis) is destabilized by less than 2 kcal/mol with respect to the classical MC state (3MCtrans), and energy barriers to populate 3MCcis and 3MCtrans from the 3MLCT state are similar according to nudged elastic band minimum energy path calculations. Distortions in the classical 3MCtrans, that is, elongation of two Ru-N bonds toward two different bpy ligands, are not expected to favor the formation of ligand-loss photoproducts. On the contrary, the new 3MCcis could be particularly relevant in the photodegradation of Ru(II) polypyridine complexes.
RESUMEN
The singlet valence excited states of an iron-porphyrin-pyrazine-carbonyl complex are investigated up to the Soret band (about 3 eV) using multi-state complete active space with perturbation at the second order (MS-CASPT2). This complex is a model for the active site of carboxy-hemoglobin/myoglobin. The spectrum of the excited states is rather dense, comprising states of different nature: dâπ* transitions, dâd states, πâπ* excitations of the porphyrin, and doubly excited states involving simultaneous intra-porphyrin πâπ* and dâd transitions. Specific features of the MS-CASPT2 method are investigated. The effect of varying the number of roots in the state average calculation is quantified as well as the consequence of targeted modifications of the active space. The effect of inclusion of standard ionization potential-electron affinity (IPEA) shift in the perturbation treatment is also investigated.