Efficacy of probing for children with congenital nasolacrimal duct obstruction: a retrospective study using fluorescein dye disappearance test and lacrimal sac echography.

PURPOSE: To evaluate B-scan echography for the assessment of lacrimal sac (LS) in pediatric epiphora secondary to congenital nasolacrimal duct obstruction (CNLDO), and to verify its predictive role in functional efficacy of nasolacrimal duct probing. PATIENTS AND METHODS: Thirty-nine eyes of 23 consecutive children, treated with a single probing for persistent CNLDO-related epiphora, were retrospectively studied. These cases were investigated both collectively and considering two sub-groups: group A (ten patients [20 eyes] 13 months. Fluorescein dye disappearance test at 10 minutes (FDDT-10) and ultrasound examination of LS were performed before and after probing. An echographic LS scoring system (grade 0 = no LS enlargement; grade 1 = slight longitudinal LS enlargement; grade 2 = longitudinal and slight transverse LS enlargement; grade 3 = marked longitudinal and transverse LS enlargement) was introduced as a predictor of probing efficacy, estimating FDDT-10 modification between pre- and post-operative checks. RESULTS: Echographic LS evaluation was easily practicable without sedation. In the total cluster and in both age sub-groups, post-probing FDDT-10 decreased with respect to pre-probing value (p < 0.001). Post-probing LS score improved with respect to pre-probing check within the total cluster and group A (p < 0.05). Strong correlation between pre-probing LS alteration and functional probing failure was present in each studied cluster (all p values <0.0001). Within group B, a greater gain of post-probing FDDT-10 was more frequent in patients with a better pre-probing LS score, as well as in younger children (both p values <0.0001). CONCLUSIONS: In children with CNLDO-related epiphora, B-scan echography of the LS can represent a reliable and useful examination for a better understanding of the functional prognosis after probing treatment.

Reading performance in patients with retinitis pigmentosa: a study using the MNREAD charts.

PURPOSE: To evaluate the relationship between reading performance and severity of disease in patients with retinitis pigmentosa (RP), assessed with routine clinical psychophysical visual tests. METHODS: Seventy-six consecutive patients with RP (145 eyes), with reading acuity of at least 1.6 logMAR (logarithm of the minimum angle of resolution) in at least one eye, were examined. Each patient underwent a complete ophthalmic evaluation, including visual acuity (Early Treatment Diabetic Retinopathy Study [ETDRS] charts), contrast sensitivity (Pelli-Robson charts), visual field perimetry (Humphrey central 30-2 full-threshold program; Carl Zeiss Meditec, Dublin, CA), and a test of reading acuity, critical print size, and maximum reading speed (Minnesota Reading charts [MNREAD]). RESULTS: Reading acuity was 1.0 logMAR or more in the better eye of all but six (92%) patients. Maximum reading speed was better than 100 words per minute in the better eye of 59 (78%) subjects. Moderate to severe reading impairment, defined as reading acuity of 0.4 logMAR or worse, was observed in the better eye of 47 (62%) patients. EDTRS visual acuity of 0.3 logMAR (20/40) or worse was 89% sensitive and 66% specific when used as a criterion to define reading impairment. Contrast sensitivity and visual acuity correlated significantly with all three reading components, whereas mean light sensitivity in the central visual field (6 degrees ) demonstrated a higher correlation with maximum reading speed. The number of years elapsed since the diagnosis of RP was a strong negative predictor of reading performance when clinical visual tests were taken into account, whereas a better reading ability characterized the patients with RP who had a higher level of education. A reduced reading speed with larger print size was found in 30 eyes (21%). This correlated with central light sensitivity, as it was more common among eyes with a mean sensitivity of <10 dB. CONCLUSIONS: The reading performance of most patients with RP is only moderately impaired. It correlates with contrast sensitivity, visual acuity, and visual field. It should be assessed in all cases, as disability can ensue, even when visual acuity is preserved. In patients with RP with poor reading performance, there is little potential for high-magnification devices because visual field constriction affects the reading rate.

Merkel cell carcinoma: a distinct lesion of the eyelid.

Merkel cell carcinoma (trabecular cell carcinoma) is a rare, distinct, primitive, neuroendocrine malignancy of the skin, usually affecting elderly patients. It develops from Merkel cells and nearly one out of every 10 Merkel cell carcinomas occurs in the eyelids and periocular region. The tumor manifests itself clinically as a bulging lesion near the lid margin, painless, reddish colored with teleangiectatic blood vessels on the surface. Histologically, the tumor can mimic malignant lymphoma, undifferentiated melanoma, sebaceous carcinoma or cutaneous metastases of pulmonary microcytoma. Immunohistochemical studies with antibodies to neuron-specific enolase, cytokeratins and neurosecretory granules are necessary to differentiate these tumors. One third of all Merkel cell carcinomas result in death. In the present paper, we present data on the clinical features, treatment and long-term follow-up of three patients.