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1.
Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome.
Bioorg Med Chem Lett
; 40: 127939, 2021 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33713780
2.
Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits.
J Pharmacol Exp Ther
; 375(3): 510-521, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33033171
3.
Synthesis and Reactivity of Spirocarbocycles as Scaffolds for Nucleoside Analogues.
J Org Chem
; 85(23): 14989-15005, 2020 12 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33196210
4.
Preparation of 4'-Spirocyclobutyl Nucleoside Analogues as Novel and Versatile Adenosine Scaffolds.
Chemistry
; 25(67): 15419-15423, 2019 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31609050
5.
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.
Bioorg Med Chem Lett
; 29(23): 126743, 2019 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31678006
6.
A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.
Blood
; 117(18): 4895-904, 2011 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-21346251
7.
Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors.
Bioorg Med Chem Lett
; 21(16): 4762-7, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21767952
8.
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
Mol Cancer Ther
; 20(12): 2317-2328, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34583982
9.
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode.
ACS Med Chem Lett
; 11(11): 2227-2231, 2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214833
10.
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors.
Bioorg Med Chem Lett
; 19(17): 5229-32, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19631532
11.
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract.
J Pharmacol Exp Ther
; 325(1): 47-55, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18192499
12.
Catalytic mechanism of Escherichia coli ribonuclease III: kinetic and inhibitor evidence for the involvement of two magnesium ions in RNA phosphodiester hydrolysis.
Nucleic Acids Res
; 33(3): 807-15, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-15699182
13.
Electron density guided fragment-based lead discovery of ketohexokinase inhibitors.
J Med Chem
; 53(22): 7979-91, 2010 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-21033679
14.
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.
PLoS One
; 4(1): e4112, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19119317
15.
Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.
J Med Chem
; 52(13): 3941-53, 2009 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-19489538
16.
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
J Med Chem
; 51(13): 3684-7, 2008 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18557609
17.
Mutational analysis of the nuclease domain of Escherichia coli ribonuclease III. Identification of conserved acidic residues that are important for catalytic function in vitro.
Biochemistry
; 43(41): 13054-62, 2004 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15476399
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