The 7-day recall period version of the Urticaria Control Test-UCT7.

BACKGROUND: The Urticaria Control Test (UCT) is a well-established, very easy to use and calculate 4-item patient-reported outcome measure to assess chronic urticaria disease control during the previous 4 weeks. Clinical trials and practice may benefit from the use of a UCT version with a shorter recall period, but this does not exist. OBJECTIVES: We sought to develop and validate a UCT version with a 7-day recall period, the UCT7. METHODS: The UCT7 was developed, based on the UCT, and tested, in 152 patients with chronic urticaria (spontaneous: n = 101, inducible: n = 51) for its reliability, validity and screening accuracy, and clinimetric properties, in other words, the cutoff for well-controlled disease and the minimal clinically important difference. RESULTS: The UCT7 showed excellent internal consistency reliability with a Cronbach αvalue of 0.91 and test-retest reliability with an intraclass correlation coefficient of 0.83. Convergent validity was high and strongly correlated with anchors of disease control, wheal and angioedema frequency, and urticaria-related quality of life impairment. The UCT7 showed excellent sensitivity to change; however, changes in angioedema activity and impact did not correlate well with changes in UCT7. Based on receiver-operating characteristic curve analysis, the proportion of correctly classified patients, and patients' assessment of treatment efficacy, we recommend a cutoff value of 12 points for identifying patients with well-controlled disease. The UCT7 minimal clinically important difference for improvement was estimated to be 2 points. CONCLUSIONS: The UCT7 is a validated 7-day recall period version of the UCT. It is ideal for the assessment of disease control at short intervals in patients with chronic urticaria in clinical studies and practice.

LEGAL REGULATION OF THE INSTITUTE OF TRANSPLANTATION IN UKRAINE.

OBJECTIVE: The aim: The aim of the study is to generalize the established by scientists features of the legal regulation of the institute of transplantation in Ukraine and other countries. PATIENTS AND METHODS: Materials and methods: The article examines the institute of transplantation, its medico-legal character, and the problems of implementing the institute in Ukraine. In the study, the authors applied general scientific methods, which include system analysis, system modeling, dialectical method. The authors used the following materials: laws, decrees of the President of Ukraine, resolutions of the government and ministries of healthcare, dissertations and articles by scientists, assessments of leading experts in the field. CONCLUSION: Conclusions: Theoretically, the legal aspect of the study of the institute of transplantation is important for formulating the general patterns of its emergence, developing prospects for its functioning and strategic directions for its further development, building a system for protecting the rights of all participants in this legal relationship. Different aspects of transplantation can be considered separately: medical or surgical; biological; psychological. But there is an equally important aspect - the legal one, which reveals the institute of transplantation from the standpoint of the protection of human dignity.

ABORTION, HUMAN RIGHTS AND MEDICAL ADVANCES IN DIGITAL AGE.

OBJECTIVE: The aim: The article analyzes the impact of abortion on human rights and women's health in the light of medical and technological advances of the digital age. PATIENTS AND METHODS: Materials and methods: The methods of research were dialectic approach and general analysis of normative and scientific sources, analysis of the results of studies of women's mental health after abortions, analysis of judicial practice, especially decisions of the European Court of Human Rights, the results of author's own empirical studies, the formal legal method, the comparative legal method and the historical method. It has been established that there is no strong evidence that abortion negatively affects a woman's mental health, including no evidence that the emotional consequences aredeeply personal, or are rather the result of societal pressure. Arguments were refuted about extending the protection of human rights regarding abortion to unborn children and their fathers. CONCLUSION: Conclusions: The article emphasizes that the ethical burden on medical workers, especially in jurisdictions that require the approval of a doctor to legally terminate a pregnancy,increases significantly due to information flows and community expectations dictated by new medical advances.