RESUMEN
Machine perfusion of marginal grafts might be a possible solution to organ shortage and a promising tool for reducing waiting list morbidity and mortality. In recent years, optimizing the circumstances of organ preservation prior to implantation via machine perfusion has become a hot topic of research. Machine perfusion offers a platform for organ reconditioning, assessment of cell viability and function, pharmacological preconditioning, prolongation of preservation time (ischemia time) and finally reducing graft injury. The objective of the new technology is to increase the pool of transplantable organs safely. Multicentric prospective studies have been evaluating the short and long term outcomes of different methods, however, several questions still remain unanswered. This review summarizes the recent advances in the field of machine perfusion, focusing on preclinical and clinical results. Machine perfusion seems to be a new milestone in the modern era of solid organ transplantation. Orv Hetil. 2018; 159(46): 1882-1890.
Asunto(s)
Trasplante de Órganos/métodos , Trasplante de Órganos/tendencias , Perfusión/métodos , Perfusión/tendencias , Trasplante de Corazón/métodos , Trasplante de Corazón/tendencias , Humanos , Trasplante de Riñón/métodos , Trasplante de Riñón/tendencias , Trasplante de Hígado/métodos , Trasplante de Hígado/tendencias , Trasplante de Pulmón/métodos , Trasplante de Pulmón/tendencias , Preservación de Órganos , Trasplante de Páncreas/métodos , Trasplante de Páncreas/tendenciasRESUMEN
In the last decades, the results of liver transplantation have shown significant improvement. More patients are eligible for liver transplantation, while the indications are changing. The worldwide shortage of donor organs urges the profession for the development of new strategies. With rational extension of donor criteria, more precise organ allocation, personalized donation, living related donation, machine perfusion, and donation after cardiac death, liver transplantation is becoming available for more and more patients suffering from end stage liver disease. Hereby we summarize the new possibilities and challenges in the light of the Hungarian liver transplant program. Orv Hetil. 2019; 160(29): 1127-1135.