RESUMEN
This paper presents a woman in her 70's with G-CSF producing anaplastic carcinoma of the pancreas(Stage IVb)who underwent chemotherapy by S-1 alone. On FDG-PET after the first course, accumulation of FDG was impaired remarkably. After the second course, the patient died of carcinomatous pleuritis and peritonitis on the 88th day after initiation of treatment. G-CSF producing anaplastic carcinoma of the pancreas is extremely rare and there are no reports with regard to response evaluation by FDG-PET. Thus, this case has significant clinical value.
Asunto(s)
Antimetabolitos Antineoplásicos/uso terapéutico , Carcinoma/diagnóstico por imagen , Ácido Oxónico/uso terapéutico , Neoplasias Pancreáticas/diagnóstico por imagen , Tomografía de Emisión de Positrones , Tegafur/uso terapéutico , Anciano , Autopsia , Carcinoma/tratamiento farmacológico , Carcinoma/metabolismo , Combinación de Medicamentos , Resultado Fatal , Femenino , Fluorodesoxiglucosa F18 , Factor Estimulante de Colonias de Granulocitos/biosíntesis , Humanos , Neoplasias Pancreáticas/tratamiento farmacológico , Neoplasias Pancreáticas/metabolismo , Pleuresia/etiologíaRESUMEN
A 37-year-old man underwent lobectomy of the right liver for granulocyte colony-stimulating factor (G-CSF) producing hepatocellular carcinoma accompanying type B hepatitis. Within two months after the surgery, lung metastases were revealed and administration of sorafenib was begun, however, the lung metastases continued to enlarge. Changing the patient's medication to tegafur-uracil provided remarkable reduction of the lung metastases. The patient is alive two years after diagnosis and receives outpatient chemotherapy. We concluded that this case is valuable with regard to the extreme rarity of G-CSF producing hepatocellular carcinoma and its successful treatment in this case.