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Observational ostracism, as a form of social exclusion, can significantly affect human behavior. However, the effects of observed ostracism on risky and ambiguous decision-making and the underlying neural mechanisms remain unclear. This event-related potential study investigated these issues by involving participants in a wheel-of- fortune task, considering observed ostracism and inclusion contexts. The results showed that the cue-P3 component was more enhanced during the choice phase for risky decisions than for ambiguous decisions in the observed inclusion contexts but not in the observed ostracism contexts. During the outcome evaluation phase, feedback-related negativity amplitudes following both risky and ambiguous decisions were higher in the no-gain condition than in the gain condition in the observed inclusion context. In contrast, this effect was only observed following risky decisions in the observed ostracism context. The feedback-P3 component did not exhibit an observed ostracism effect in risky and ambiguous decision-making tasks. Risk levels further modulated the cue-P3 and feedback-related negativity components, while ambiguity levels further modulated the feedback-P3 components. These findings demonstrate a neural dissociation between risk and ambiguity decision-making during observed ostracism that unfolds from the choice phase to the outcome evaluation phase.
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Toma de Decisiones , Electroencefalografía , Asunción de Riesgos , Humanos , Masculino , Femenino , Toma de Decisiones/fisiología , Adulto Joven , Adulto , Potenciales Evocados/fisiología , Encéfalo/fisiología , Aislamiento Social/psicología , Señales (Psicología)RESUMEN
Arterial spin-labeled perfusion and blood oxygenation level-dependent functional MRI are indispensable tools for noninvasive human brain imaging in clinical and cognitive neuroscience, yet concerns persist regarding the reliability and reproducibility of functional MRI findings. The circadian rhythm is known to play a significant role in physiological and psychological responses, leading to variability in brain function at different times of the day. Despite this, test-retest reliability of brain function across different times of the day remains poorly understood. This study examined the test-retest reliability of six repeated cerebral blood flow measurements using arterial spin-labeled perfusion imaging both at resting-state and during the psychomotor vigilance test, as well as task-induced cerebral blood flow changes in a cohort of 38 healthy participants over a full day. The results demonstrated excellent test-retest reliability for absolute cerebral blood flow measurements at rest and during the psychomotor vigilance test throughout the day. However, task-induced cerebral blood flow changes exhibited poor reliability across various brain regions and networks. Furthermore, reliability declined over longer time intervals within the day, particularly during nighttime scans compared to daytime scans. These findings highlight the superior reliability of absolute cerebral blood flow compared to task-induced cerebral blood flow changes and emphasize the importance of controlling time-of-day effects to enhance the reliability and reproducibility of future brain imaging studies.
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Encéfalo , Circulación Cerebrovascular , Imagen por Resonancia Magnética , Descanso , Humanos , Masculino , Femenino , Adulto , Circulación Cerebrovascular/fisiología , Reproducibilidad de los Resultados , Descanso/fisiología , Encéfalo/diagnóstico por imagen , Encéfalo/fisiología , Encéfalo/irrigación sanguínea , Adulto Joven , Imagen por Resonancia Magnética/métodos , Imagen de Perfusión/métodos , Desempeño Psicomotor/fisiología , Ritmo Circadiano/fisiología , Nivel de Alerta/fisiologíaRESUMEN
People prefer active decision-making and induce greater emotional feelings than computer-based passive mode, yet the modulation of decision-making mode on outcome evaluation remains unknown. The present study adopted event-related potentials to investigate the discrepancies in active and computer-based passive mode on outcome evaluation using a card gambling task. The subjective rating results showed that active mode elicited more cognitive effort and stronger emotional feelings than passive mode. For received outcomes, we observed no significant Feedback-Related Negativity (FRN) effect on difference waveshapes (d-FRN) between the 2 modes, but active decision-making elicited larger P300 amplitudes than the passive mode. For unchosen card outcomes, the results revealed larger d-FRN amplitudes of relative valences (Superior - Inferior) in responses to negative feedback in active mode than in passive mode. The averaged P300 results revealed an interplay among outcome feedback, decision-making mode, and relative valence, and the average P300 amplitude elicited by the received loss outcome in the active mode partially mediated the relationship between subjective cognitive effort and negative emotion ratings on loss. Our findings indicate discrepancies between active and computer-based passive modes, and cognitive effort and emotional experience involved in outcome evaluation.
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Toma de Decisiones , Electroencefalografía , Humanos , Electroencefalografía/métodos , Autoinforme , Emociones , Potenciales Evocados , Retroalimentación Psicológica , Computadores , EncéfaloRESUMEN
Humans may behave in different manners when making decisions with friends and strangers. Whether the interpersonal relationship and the characteristics of the individuals in the group affected the group decision-making under uncertainty in the real-time interaction remains unknown. Using the turn-based Balloon Analogue Risk Task (BART), the present study examined the group decision-making propensity under uncertainty with partners in different interpersonal relationships and interpersonal orientations. Corresponding inter-brain synchronization (IBS) patterns at the prefrontal cortex (PFC) were also uncovered with the fNIRS-based hyperscanning approach. Behavioral results identified that dyads in the friend group exhibited the uncertainty-averse propensity when comparing with the stranger group. The fNIRS results reported that feedback-related IBS at the left inferior frontal gyrus (l-IFG) and medial frontopolar cortex (mFPC) during different feedbacks was modulated by interpersonal relationships. The IBS at all channels in the PFC during the positive and negative feedbacks, respectively, predicted the decision-making propensity under uncertainty in the stranger and friend groups based on the support vector machine (SVM) algorithm. The moderating role of the social value orientation (SVO) was also verified in the mediation effect of the dyad closeness on the decision-making propensity under uncertainty via the IBS at the right lateral frontopolar cortex (r-FPC). These findings demonstrated disparate behavioral responses and inter-brain synchronization patterns underlying group decision-making under uncertainty with partners in different interpersonal relationships.
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Mapeo Encefálico , Humanos , Encéfalo/fisiología , Mapeo Encefálico/métodos , Relaciones Interpersonales , Corteza Prefrontal/diagnóstico por imagen , Corteza Prefrontal/fisiología , Espectroscopía Infrarroja Corta/métodos , IncertidumbreRESUMEN
OBJECTIVE: The purpose of the present study was to examine the influence of maternal pre-pregnancy BMI and gestational weight gain (GWG) on initiation and duration of infant breast-feeding in a prospective birth cohort study. DESIGN: Breast-feeding information was collected at 1, 3, 6 and 12 months postpartum. The association of pre-pregnancy BMI and GWG with delayed lactogenesis II and termination of exclusive breast-feeding was assessed with logistic regression analysis. The risk of early termination of any breast-feeding during the first year postpartum was assessed with Cox proportional hazards models. SETTING: Urban city in China. SUBJECTS: Women with infants from the Ma'anshan Birth Cohort Study (n 3196). RESULTS: The median duration of any breast-feeding in this cohort was 7·0 months. Pre-pregnancy obese women had higher risks of delayed lactogenesis II (risk ratio=1·89; 95 % CI 1·04, 3·43) and early termination of any breast-feeding (hazard ratio=1·38; 95 % CI 1·09, 1·75) adjusted for potential maternal and infant confounders, when compared with normal-weight women. No differences in breast-feeding initiation or duration of exclusive breast-feeding according to pre-pregnancy BMI were found. Moreover, GWG was not associated with any poor breast-feeding outcomes. CONCLUSIONS: The present study indicated that pre-pregnancy obesity increases the risks of delayed lactogenesis II and early termination of any breast-feeding in Chinese women.
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Índice de Masa Corporal , Lactancia Materna , Obesidad/epidemiología , Aumento de Peso , Adulto , China/epidemiología , Femenino , Estudios de Seguimiento , Humanos , Estudios Longitudinales , Periodo Posparto , Embarazo , Prevalencia , Modelos de Riesgos Proporcionales , Estudios Prospectivos , Factores de Riesgo , Factores Socioeconómicos , Encuestas y CuestionariosRESUMEN
Recent studies have shown that the processing of neutral facial expressions could be modulated by the valence and self-relevance of preceding verbal evaluations. However, these studies have not distinguished the dimension (i.e., morality and competence) from verbal evaluations. In fact, there is a hot controversy about whether morality or competence receives more weight. Therefore, using the ERP technique, the current study aimed to address this issue by comparing the influence of morality and competence evaluations on behavioral and neural responses to neutral facial expressions when these evaluations varied with contextual valence and self-relevance. Our ERP results revealed that the early EPN amplitudes were larger for neutral faces after receiving evaluations about self relative to evaluations about senders. Moreover, the EPN was more negative after a competence evaluation relative to a morality evaluation when these evaluations were positive, while this effect was absent when these evaluations were negative. The late LPP was larger after a morality evaluation compared to a competence evaluation when these evaluations were negative and directed to self. However, no significant LPP effect between morality and competence evaluations was observed when these evaluations were positive. The present study extended previous studies by showing that early and late processing stages of faces are affected by the evaluation dimension in a top-down manner and further modulated by contextual valence and self-relevance.
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Electroencefalografía , Potenciales Evocados , Principios Morales , Humanos , Femenino , Masculino , Adulto Joven , Adulto , Potenciales Evocados/fisiología , Expresión Facial , Reconocimiento Facial/fisiología , Estimulación Luminosa/métodos , Adolescente , AutoimagenRESUMEN
Previous work has demonstrated the interpersonal implications of advisees' decisions (acceptance or rejection) on advisors' advice-giving behavior in subsequent exchanges. Here, using an ERP technique, we investigated how advisees' facial feedback (smiling, neutral, or frowning) accompanying their decisions (acceptance or rejection) influenced advisors' feedback evaluation from advisees and their advice-giving in subsequent exchanges. Behaviorally, regardless of whether the advice was accepted or rejected, advisors who received smiling-expression feedback would show higher willingness rates in subsequent advice-giving decisions, while advisors who received frowning-expression feedback would show lower willingness rates. On the neural level, in the feedback evaluation stage, the FRN and P3 responses were not sensitive to facial feedback. In contrast, frowning-expression feedback elicited a larger LPC amplitude than neutral- and smiling-expression feedback, regardless of whether the advice was accepted or rejected. In the advice decision stage, advisors who received neutral-expression feedback showed a larger N2 in making decisions than advisors who received frowning-expression feedback only after the advice was rejected. Additionally, Advisors who received smiling- and neutral-expression feedback showed a larger P3 in making decisions than advisors who received frowning-expression feedback only after the advice was accepted. In sum, the current findings extended previous research findings by showing that the effect of advisees' facial expressions on the advisors' advice-giving existed in multiple stages, including both the feedback evaluation stage and the advice decision stage.
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Toma de Decisiones , Sonrisa , Humanos , Retroalimentación , Expresión FacialRESUMEN
The framing effect refers to the phenomenon that different descriptions of the same option lead to a shift in the choice of the decision maker. Several studies have found that emotional contexts irrelevant to a decision in progress still influence the framing effect on decision making. However, little is known about the potential role of emotional contexts in the framing effect on outcome evaluation under uncertainty and the related neural mechanisms. The present study measured event-related potentials (ERPs) to capture the time series of brain activities during the processing of gain- and loss-framed choices and outcomes primed with neutral and negative emotional contexts. The results revealed that in the neutral emotional context, the P300 amplitudes following both positive and negative feedback were greater in the gain-framed condition than those in the loss-framed condition, demonstrating a framing effect, whereas in the negative emotional context, this effect was unstable and observed only following negative feedback. In contrast, regardless of whether the feedback was positive or negative, the framing effect on the feedback-related negativity (FRN) amplitudes was insensitive to neutral and negative emotional contexts. Furthermore, the time-frequency analysis showed that the framing effect on the theta power related to the FRN was also insensitive to neutral and negative emotional contexts. Our findings suggest that brain responses to framing effects on outcome evaluation in a later cognitive appraisal stage of decision making under uncertainty may depend on the emotional context, as the effects were observed only following negative feedback in the negative emotional context.
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Toma de Decisiones , Emociones , Humanos , Incertidumbre , Toma de Decisiones/fisiología , Emociones/fisiología , Encéfalo/fisiología , Potenciales Evocados/fisiología , ElectroencefalografíaRESUMEN
Recently, several studies have found a recognition advantage for facial expressions, particularly angry expressions, when they appear on high-status faces rather than low-status faces. In the present study, we used event-related potentials (ERPs) to explore the influence of social status on the neural responses to others' facial expressions in a context of performance monitoring. Specifically, we used an interactive rank-inducing task (i.e., time estimation task) to manipulate social partners' status (high versus low) and then told participants that they would receive social feedback (i.e., happy, neutral, or angry) from social partners with high or low status after completing the task. ERP results revealed the preferential processing of high-status targets at both early (P1/N170/FRN) and late (P3) temporal stages of facial expression processing. Notably, larger FRN amplitudes elicited by feedback from high-status partners were observed in happy, neutral, and angry expression contexts, whereas larger P3 amplitudes elicited by feedback from high-status partners were only evident in both neutral and angry expression contexts but not in happy expression context. Together, the present study extended previous studies by showing that the perception of facial expressions could be modulated by target status at multiple stages.
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Expresión Facial , Reconocimiento Facial , Humanos , Estatus Social , Emociones/fisiología , Electroencefalografía/métodos , Potenciales Evocados/fisiología , Reconocimiento Facial/fisiologíaRESUMEN
Introduction: Advice-giving is a double-edged sword in social interaction, which could bring benefits or considerable losses for the advisee. However, whether the social relationship affects the time course of advisor's brain response to outcome evaluation after the advice-giving remains unclear. Methods: In the present study, we used event-related potentials (ERPs) to investigate the modulation of social relationships on advisor's outcome feedback processing after the advice-giving and related neural activities. Results: The results showed larger feedback-related negativity (FRN) to a loss than to a gain both when the friends accepted and rejected the advice, whereas this effect only existed when the strangers rejected the advice, but not when they accepted it. In contrast, the P3 results demonstrated the enhanced neural sensitivity when the strangers accepted the advice than rejected it despite leading to a loss, while a larger P3 amplitude was found when the friends accepted the advice than rejected it and brought a gain. The theta oscillation results in the friend group revealed stronger theta power to loss when the advisee accepted the advice than rejected it. However, this effect was absent in the stranger group. Discussion: These results suggested that outcome evaluation in advice-giving was not only influenced by feedback valence and social reward, but also modulated by social relationships. Our findings contributed to the understanding of the neural mechanisms of advice-giving outcome evaluation in a social context.
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Previous experience often guides people's decision-making. How the corresponding consecutive outcomes in the gain-loss frame modulate feedback evaluation in dynamic situations remains unclear. In this study, we used event-related potentials (ERPs) with a Balloon Analogue Risk Task (BART) to investigate the effect of the consistency with previous feedback on current choices under the gain-loss frame and the neural mechanism by coding ERP signals evoked by consecutive outcomes among adults (N = 42). Results indicated that the framing effect on feedback-related negativity (FRN) amplitudes following current feedback in decision-making was insensitive to prior feedback. In contrast, the P300 amplitudes following two inconsistent consecutive rounds of feedback were greater than that following two consistent consecutive rounds of feedback in the gain frame, while this effect was absent in the loss frame, revealing a more significant valance-framing effect. These findings demonstrate that two inconsistent rounds of feedback enhance the framing effect, and suggest that the framing effect is sensitive to prior feedback in a late cognitive appraisal stage in decision-making under uncertainty, rather than in an early feedback processing stage. The present study provides novel insights into how consecutive outcomes in the gain-loss frame modulate feedback evaluation in dynamic situations.
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Toma de Decisiones , Electroencefalografía , Adulto , Humanos , Retroalimentación , Toma de Decisiones/fisiología , Potenciales Evocados/fisiología , Retroalimentación Psicológica/fisiología , Encéfalo/fisiologíaRESUMEN
With the help of event-related potentials (ERPs), the present study used an oddball paradigm to investigate how both individual and target power modulate neural responses to angry expressions. Specifically, participants were assigned into a high-power or low-power condition. Then, they were asked to detect a deviant angry expression from a high-power or low-power target among a series of neutral expressions, while behavioral responses and electroencephalogram (EEG) were recorded. The behavioral results showed that high-power individuals responded faster to detect angry expressions than low-power individuals. The ERP analysis showed that high-power individuals showed larger P3 amplitudes in response to angry expressions than low-power individuals did. Target power increased the amplitudes of the P1, VPP, N3, and P3 in response to angry expressions did, but decreased the amplitudes of the N1 and N170 in response to angry expressions. The present study extended previous studies by showing that having more power could enhance individuals' neural responses to angry expressions in the late-stage processes, and individuals could show stronger neural responses to angry expressions from high-power persons in both the early- and late-stage processes.
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The relationship between prenatal arsenic exposure at low levels and poor development in children, especially in regard to neurodevelopment, has aroused several concerns, but the conclusions have been inconsistent. It still remains unclear whether such adverse effect is associated with a specific profile of the developing brain in early life. To investigate the association between arsenic exposure in utero and children's development and behaviour, we performed a large prospective birth cohort study including 2315 mother-infant pairs in Anhui Province, China. The Ages and Stages Questionnaire of China (ASQ-C) was used to assess the status of children's development and behaviour at 6â¯months postpartum, and the levels of arsenic were determined in umbilical cord serum samples. Odds ratios for suspected developmental delay (SDD) in each domain of the ASQ-C clusters were estimated using logistic regression models. Compared with low arsenic levels group, medium and high arsenic levels were significantly associated with the increased risks of SDD in the personal-social domain among infants aged 6â¯months after adjustment for all potential confounders (ORâ¯=â¯1.33, 95% CI (1.01, 1.75) and ORâ¯=â¯1.47, 95% CI (1.08, 2.00), respectively). Sex stratification analysis demonstrated that this association was stronger in females. The sensitivity analyses also showed that high cord serum arsenic levels were associated with a 1.80-fold (95% CIs (1.12, 2.90)) higher risk of a more severe developmental delay in the personal-social domain among six-month-old females. Our results suggest that low-level arsenic exposure in utero could have an adverse domain-specific effect on children's development at 6â¯months of age, particularly among females. Further studies are warranted to support the findings and explore the mechanism of these domain-and sex-specific associations.
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Arsénico , Desarrollo Infantil , Efectos Tardíos de la Exposición Prenatal , Arsénico/toxicidad , Desarrollo Infantil/efectos de los fármacos , China , Estudios de Cohortes , Femenino , Humanos , Lactante , Masculino , Embarazo , Estudios ProspectivosRESUMEN
Cobalt is an essential trace element and has been suggested to be involved in oxidative stress and inflammatory responses. However, researches have paid little attention to the association between serum cobalt levels during pregnancy and the risk of preterm birth (PTB, <37 week of gestation). The purpose of this study was to determine the association between maternal and umbilical cord serum cobalt concentrations and the risk of PTB. A total of 2951, 3080, and 2698 serum samples were obtained from pregnant women in the first, the second trimester, and the umbilical cord blood, respectively. The tertile levels of ln-transformed cobalt were defined as low, medium and high levels for cobalt respectively. In our study, the rate of PTB (<37 weeks of gestation) was elevated in subjects with low cobalt levels in the first trimester of pregnancy (adjusted OR 1.61, 95% CI: 1.01, 2.58) and the second trimester of pregnancy (adjusted OR 1.62, 95% CI: 1.03, 2.54). The adjusted OR for PTB was 2.46 (95% CI: 1.34, 4.53) among subjects with low cobalt levels and 2.22 (95% CI: 1.19, 4.15) among subjects with medium cobalt levels in the umbilical cord serum. Our findings demonstrated that the lower levels in maternal and umbilical cord serum cobalt were associated with the increased the risk of PTB.
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Cobalto/sangre , Sangre Fetal/química , Primer Trimestre del Embarazo/sangre , Segundo Trimestre del Embarazo/sangre , Nacimiento Prematuro/etiología , Adulto , China , Estudios de Cohortes , Femenino , Humanos , Recién Nacido , Modelos Logísticos , Embarazo , Nacimiento Prematuro/sangre , Factores de RiesgoRESUMEN
Gestational diabetes mellitus (GDM) is a common obstetric complication with adverse effects on both mothers and their children. Previous studies revealed the link between Arsenic (As) exposure and incidence of diabetes mellitus (DM), but the data on the association between maternal As exposure and GDM is scarce. We examined this association among a population-based birth cohort. As concentrations were determined at multiple time points during pregnancy by ICP-MS. The association between As levels and GDM prevalence was examined using logistic regression model after adjustment for confounders. A total of 419 (12.85%) women were diagnosed with GDM. The incidences of GDM gradually increased with increasing quartiles of As levels with significant trend. As levels were associated with the GDM (95%CI: 1.29-2.43) at only the 4th quartile in the first trimester. After adjustment for maternal age, prepregnancy body mass index (BMI), monthly income, gestational age and parity, the association remains significant (95%CI: 1.22-2.38). Stratified analyses showed the associations were largely limited to normal maternal age (95%CI: 1.19-3.04) and normal weight women (95%CI: 1.18-2.66). Our study showed an association between As and GDM in a birth cohort and explored first trimester may be the critical period for As associated GDM. This association was universal in the general pregnant population of normal age and of normal weight.
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Arsénico/sangre , Diabetes Gestacional/sangre , Adulto , Índice de Masa Corporal , Estudios de Cohortes , Diabetes Gestacional/inducido químicamente , Femenino , Humanos , Recién Nacido , Modelos Logísticos , Edad Materna , Exposición Materna , Embarazo , Estudios Prospectivos , Adulto JovenRESUMEN
Cobalt (Co) is an essential trace element and has been suggested to be involved in blood pressure regulation, but few studies have focused on serum Co status during pregnancy and the risks of pregnancy-induced hypertension syndrome (PIH). The aim of this study was to prospectively assess the association between serum Co levels during pregnancy and the risks of PIH, and to explore how the maternal Co status contributes to the incidence of PIH. 3260 non-hypertensive women before pregnancy with singleton births in Ma'anShan birth cohort study (MABC) were recruited with the assessment of maternal Co concentrations, additionally, the levels of 7 inflammatory factors and 3 stress factors in placentas were also determined. Relative risks (RRs) [95% confidence intervals (CIs)] for the risks of PIH were assessed and the relationships between 10 factors and maternal Co status during pregnancy were evaluated as well. A total of 194 (5.95%) women were diagnosed with PIH. The concentrations of Co varied from the first trimester to the second trimester, and maternal serum Co concentrations during pregnancy were negatively associated with the incidence of PIH in a linear fashion. There was a clear trend in RRs according to decreasing exposure to Co levels in the second trimester (RRa=1.80, 95% CI (1.26, 2.56); RRb=1.73, 95% CI (1.21, 2.46) and RRc=1.43, 95% CI (1.02, 2.04) when low Co levels comparing with high Co levels before and after adjustment for confounders; and RRa=1.29, 95% CI (0.88, 1.88); RRb=1.28, 95% CI (0.87, 1.87) and RRc=1.25, 95% CI (0.86, 1.82) when medium Co levels comparing with high Co levels before and after adjustment for confounders). In addition, the trend for the first trimester was nearly identifical to those for the second trimester (RRa=1.35, 95% CI (0.94, 1.93); RRb=1.33, 95% CI (0.93, 1.91); RRc=1.22, 95%CI (0.86, 1.73) when low Co levels comparing with high Co levels before and after adjustment for confounders; and RRa=1.10, 95% CI (0.76, 1.60); RRb=1.13, 95% CI (0.77, 1.64) and RRc=1.12, 95% CI (0.77, 1.63) before and after adjustment for confounders). Interestingly, Co concentrations in the second trimester were also inversely associated with the levels of some inflammatory factors and all three stress factors in placentas. This prospective study suggested that lower maternal serum Co concentration in the second trimester may associate with the incidence of PIH in Chinese population. Additionally, the maternal Co concentrations in the second trimester could reduce inflammatory and oxidative damage to the placenta. Further evidence is needed to support the findings and assess the mechanisms underlying the association.
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Cobalto/sangre , Hipertensión Inducida en el Embarazo/sangre , Adulto , Presión Sanguínea , Femenino , Humanos , Hipertensión Inducida en el Embarazo/epidemiología , Hipertensión Inducida en el Embarazo/fisiopatología , Embarazo , Primer Trimestre del Embarazo , Segundo Trimestre del Embarazo , Estudios Prospectivos , Medición de Riesgo , Factores de RiesgoRESUMEN
Our study aimed to assess the distribution of copper (Cu) in umbilical cord serum and estimated the association between umbilical serum Cu status and neonatal birth outcomes in a Chinese population. Through the Ma'anShan Birth Cohort Study, 2689 maternal-singleton pairs with detailed birth records and available serum samples were identified. The tertile levels of ln-transformed Cu were used to define low, medium, and high levels for serum Cu. The median for umbilical cord serum Cu was 298.2 µg/L with a range of 123.1-699.6 µg/L in this study population. Our study found a positive association between the concentration of serum Cu in the umbilical cord and the duration of gestation. Compared with medium Cu levels, we found that infants with low Cu levels had a significant higher risk of preterm birth (OR = 5.06, 95% CI 2.74, 9.34) and early-term birth (OR = 1.36, 95% CI 1.10, 1.69) in the crude model. We also found that infants with high Cu levels had a significant higher risk of late- or post-term birth (OR = 1.47, 95% CI 1.11, 1.95). A significant higher risk of preterm, early-term, and late- or post-term birth still remained, even after adjustment for potential confounding factors. Our findings suggested that both Cu deficiency and Cu overload had an adverse effect on neonatal birth outcomes.
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Cobre/análisis , Sangre Fetal/química , Femenino , Humanos , Recién Nacido , Embarazo , Resultado del Embarazo , Estudios ProspectivosRESUMEN
Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in utero exposure to metallic and metalloid elements. The method only required as little as 100 µL of serum diluted 1:25 for direct analysis. Matrix-matched protocol was used to eliminate mass matrix interference and kinetic energy discrimination mode was used to eliminate the polyatomic ion interference. The assay was completed on average within 4 min with the detection limits ranging from 0.0002 to 44.4 µg/L for all the targeted elements. The detection rates for most of elements were 100 % other than cadmium (Cd), lead (Pb), and mercury (Hg). The testing results of the certified reference materials were ideal. The method is simple and sensitive, so it is suitable for the monitoring of large quantities of samples.