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1.

The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.

Tarsounas, Madalena; Sung, Patrick.

Nat Rev Mol Cell Biol ; 21(5): 284-299, 2020 05.

Artículo en Inglés | MEDLINE | ID: mdl-32094664

2.

A PARP1-TIMELESS alliance in cancer therapy.

Tarsounas, Madalena.

Mol Cell ; 84(10): 1824-1825, 2024 May 16.

Artículo en Inglés | MEDLINE | ID: mdl-38759623

3.

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.

Groelly, Florian J; Dagg, Rebecca A; Petropoulos, Michalis; Rossetti, Giacomo G; Prasad, Birbal; Panagopoulos, Andreas; Paulsen, Teressa; Karamichali, Angeliki; Jones, Samuel E; Ochs, Fena; Dionellis, Vasilis S; Puig Lombardi, Emilia; Miossec, Matthieu J; Lockstone, Helen; Legube, Gaëlle; Blackford, Andrew N; Altmeyer, Matthias; Halazonetis, Thanos D; Tarsounas, Madalena.

Mol Cell ; 82(18): 3382-3397.e7, 2022 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-36002001

4.

DNA Damage and Cancer Immunotherapy: A STING in the Tale.

Reisländer, Timo; Groelly, Florian J; Tarsounas, Madalena.

Mol Cell ; 80(1): 21-28, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-32810436

5.

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer, Jutta; Tacconi, Eliana M C; Folio, Cecilia; Badie, Sophie; Porru, Manuela; Klare, Kerstin; Tumiati, Manuela; Markkanen, Enni; Halder, Swagata; Ryan, Anderson; Jackson, Stephen P; Ramadan, Kristijan; Kuznetsov, Sergey G; Biroccio, Annamaria; Sale, Julian E; Tarsounas, Madalena.

Mol Cell ; 61(3): 449-460, 2016 Feb 04.

Artículo en Inglés | MEDLINE | ID: mdl-26748828

6.

Oligonucleotide-Functionalized Gold Nanoparticles for Synchronous Telomerase Inhibition, Radiosensitization, and Delivery of Theranostic Radionuclides.

Bavelaar, Bas M; Song, Lei; Jackson, Mark R; Able, Sarah; Tietz, Ole; Skaripa-Koukelli, Irini; Waghorn, Philip A; Gill, Martin R; Carlisle, Robert C; Tarsounas, Madalena; Vallis, Katherine A.

Mol Pharm ; 18(10): 3820-3831, 2021 10 04.

Artículo en Inglés | MEDLINE | ID: mdl-34449222

7.

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.

Michl, Johanna; Zimmer, Jutta; Tarsounas, Madalena.

EMBO J ; 35(9): 909-23, 2016 05 02.

Artículo en Inglés | MEDLINE | ID: mdl-27037238

8.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

Badie, Sophie; Carlos, Ana Rita; Folio, Cecilia; Okamoto, Keiji; Bouwman, Peter; Jonkers, Jos; Tarsounas, Madalena.

EMBO J ; 34(3): 410-24, 2015 Feb 03.

Artículo en Inglés | MEDLINE | ID: mdl-25582120

9.

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

Martínez, Paula; Thanasoula, Maria; Muñoz, Purificación; Liao, Chunyan; Tejera, Agueda; McNees, Carolyn; Flores, Juana M; Fernández-Capetillo, Oscar; Tarsounas, Madalena; Blasco, Maria A.

Genes Dev ; 23(17): 2060-75, 2009 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-19679647

10.

How homologous recombination maintains telomere integrity.

Tacconi, Eliana M C; Tarsounas, Madalena.

Chromosoma ; 124(2): 119-30, 2015 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-25430998

11.

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.

Thanasoula, Maria; Escandell, Jose Miguel; Suwaki, Natsuko; Tarsounas, Madalena.

EMBO J ; 31(16): 3398-410, 2012 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-22842784

12.

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.

Chaikuad, Apirat; Tacconi, Eliana M C; Zimmer, Jutta; Liang, Yanke; Gray, Nathanael S; Tarsounas, Madalena; Knapp, Stefan.

Nat Chem Biol ; 10(10): 853-60, 2014 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-25195011

13.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

Badie, Sophie; Carlos, Ana Rita; Folio, Cecilia; Okamoto, Keiji; Bouwman, Peter; Jonkers, Jos; Tarsounas, Madalena.

EMBO J ; 34(6): 828, 2015 Mar 12.

Artículo en Inglés | MEDLINE | ID: mdl-25766694

14.

RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.

Suwaki, Natsuko; Klare, Kerstin; Tarsounas, Madalena.

Semin Cell Dev Biol ; 22(8): 898-905, 2011 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-21821141

15.

High-resolution mapping of mitotic DNA synthesis under conditions of replication stress in cultured cells.

Groelly, Florian J; Dagg, Rebecca A; Mailler, Jonathan; Halazonetis, Thanos D; Tarsounas, Madalena.

STAR Protoc ; 4(1): 101970, 2023 03 17.

Artículo en Inglés | MEDLINE | ID: mdl-36598851

16.

Targeting DNA damage response pathways in cancer.

Groelly, Florian J; Fawkes, Matthew; Dagg, Rebecca A; Blackford, Andrew N; Tarsounas, Madalena.

Nat Rev Cancer ; 23(2): 78-94, 2023 02.

Artículo en Inglés | MEDLINE | ID: mdl-36471053

17.

MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer.

Dinami, Roberto; Pompili, Luca; Petti, Eleonora; Porru, Manuela; D'Angelo, Carmen; Di Vito, Serena; Rizzo, Angela; Campani, Virginia; De Rosa, Giuseppe; Bruna, Alejandra; Serra, Violeta; Mano, Miguel; Giacca, Mauro; Leonetti, Carlo; Ciliberto, Gennaro; Tarsounas, Madalena; Stoppacciaro, Antonella; Schoeftner, Stefan; Biroccio, Annamaria.

EMBO Mol Med ; 15(1): e16033, 2023 01 11.

Artículo en Inglés | MEDLINE | ID: mdl-36426578

18.

It's getting HOT at telomeres.

Tarsounas, Madalena.

EMBO J ; 32(12): 1655-7, 2013 Jun 12.

Artículo en Inglés | MEDLINE | ID: mdl-23685360

19.

Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours.

Groelly, Florian J; Porru, Manuela; Zimmer, Jutta; Benainous, Hugo; De Visser, Yanti; Kosova, Anastasiya A; Di Vito, Serena; Serra, Violeta; Ryan, Anderson; Leonetti, Carlo; Bruna, Alejandra; Biroccio, Annamaria; Tarsounas, Madalena.

EMBO Mol Med ; 14(3): e14501, 2022 03 07.

Artículo en Inglés | MEDLINE | ID: mdl-35107878

20.

A transcription-based mechanism for oncogenic ß-catenin-induced lethality in BRCA1/2-deficient cells.

Dagg, Rebecca A; Zonderland, Gijs; Lombardi, Emilia Puig; Rossetti, Giacomo G; Groelly, Florian J; Barroso, Sonia; Tacconi, Eliana M C; Wright, Benjamin; Lockstone, Helen; Aguilera, Andrés; Halazonetis, Thanos D; Tarsounas, Madalena.

Nat Commun ; 12(1): 4919, 2021 08 13.

Artículo en Inglés | MEDLINE | ID: mdl-34389725

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The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.

A PARP1-TIMELESS alliance in cancer therapy.

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.

DNA Damage and Cancer Immunotherapy: A STING in the Tale.

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Oligonucleotide-Functionalized Gold Nanoparticles for Synchronous Telomerase Inhibition, Radiosensitization, and Delivery of Theranostic Radionuclides.

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

How homologous recombination maintains telomere integrity.

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.

High-resolution mapping of mitotic DNA synthesis under conditions of replication stress in cultured cells.

Targeting DNA damage response pathways in cancer.

MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer.

It's getting HOT at telomeres.

Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours.

A transcription-based mechanism for oncogenic ß-catenin-induced lethality in BRCA1/2-deficient cells.