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Introduction Migraine, as a major cause of headaches, showcases the need for the public to be well aware of it. The legitimacy and quality of YouTube as a platform to find information regarding migraine have not been validated. The aim of this study was to assess the content, quality, and reliability of information about migraine on YouTube. Methodology Videos were reviewed on YouTube after searching for relevant keywords. They were screened for a predetermined inclusion criterion and they entered into a performed questionnaire by authors. Using the Global Quality Scale and DISCERN scale, the effectiveness of the videos was evaluated. These videos were further analyzed for viewership and their relation to the effectiveness of the videos by the Video Power Index (VPI). Results The videos published by "others" had the highest VPI, at 517.13, followed by videos uploaded by doctors, at 117.91. The difference in the VPI was determined to be statistically significant across various groups (p=0.033). The doctors' videos received the highest reliability ratings, but the difference between them and "others" was not statistically significant (p=0.317). Conclusions Videos regarding migraine on YouTube could be more effective. The latest preventive strategies must be provided, together with supporting evidence from the authors.
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BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a hereditary cardiac disorder characterized by abnormal thickening of the left ventricular myocardium. This can lead to various clinical manifestations, including sudden death. AIM: To investigate the cardiac remodeling and functional changes in patients with HCM over a specific time period and explore the impact of different treatment regimens on disease progression. METHODS: We conducted a prospective longitudinal observational study involving 100 patients diagnosed with HCM. Baseline clinical data, including demographics, medical history, and echocardiographic measurements, were collected. Follow-up assessments were performed at regular intervals over 24 months to track changes in cardiac structure, function, and clinical status. Statistical analysis, including paired t-tests and subgroup analysis, was conducted to identify significant associations and differences between treatment groups. RESULTS: A total of 100 patients (mean age = 55 years, 50% male) were enrolled in the study. At baseline, echocardiography revealed increased left ventricular wall thickness (mean = 18.5 mm), left atrial dimensions (mean = 39 mm), and ventricular mass (mean = 230 g). During the follow-up period, there was a progressive increase in left ventricular wall thickness (mean change = 1.0 mm/year, p < 0.001), left atrial dimensions (mean change = 3.0 mm/year, p < 0.001), and ventricular mass (mean change = 8 g/year, p = 0.003). Additionally, alterations in diastolic and systolic function parameters were noted, with a decline in E/A ratio (mean change = -0.1 units/year, p = 0.008) and a reduction in ejection fraction (mean change = -2.0% per year, p = 0.001). CONCLUSION: Our longitudinal observational study provides important insights into the cardiac remodeling and functional changes in patients with HCM over time. The progressive increase in cardiac parameters indicates ongoing disease progression. Additionally, beta-blocker therapy was associated with a slower rate of left ventricular wall thickening. These findings contribute to a better understanding of HCM's natural history and may guide targeted therapeutic approaches to improve patient outcomes.
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A rheological probe that can measure mechanical properties of biological milieu at well-defined locations with high spatial resolution, on a time scale faster than most biological processes, can further improve our understanding of how living systems operate and behave. Here, we demonstrate nanorobots actively driven in realistic ex vivo biological systems for fast mechanical measurements with high spatial accuracy. In the various demonstrations of magnetic nanobots as mechanical probes, we report the first direct observation of the internalization of probes by a living cell, the accurate measurement of the 'fluid phase' cytoplasmic viscosity of ~200 cP for a HeLa cell, demonstration of intracellular measurements in cells derived from human patients; all of which establish the strength of this novel technique for measurements in both intra- and extracellular environments.