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1.

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides.

O'Brien, Darragh P; Jones, Hannah B L; Guenther, Franziska; Murphy, Emma J; England, Katherine S; Vendrell, Iolanda; Anderson, Malcolm; Brennan, Paul E; Davis, John B; Pinto-Fernández, Adán; Turnbull, Andrew P; Kessler, Benedikt M.

Mol Cell Proteomics ; 22(8): 100609, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37385347

2.

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull, Andrew P; Ioannidis, Stephanos; Krajewski, Wojciech W; Pinto-Fernandez, Adan; Heride, Claire; Martin, Agnes C L; Tonkin, Louise M; Townsend, Elizabeth C; Buker, Shane M; Lancia, David R; Caravella, Justin A; Toms, Angela V; Charlton, Thomas M; Lahdenranta, Johanna; Wilker, Erik; Follows, Bruce C; Evans, Nicola J; Stead, Lucy; Alli, Cristina; Zarayskiy, Vladislav V; Talbot, Adam C; Buckmelter, Alexandre J; Wang, Minghua; McKinnon, Crystal L; Saab, Fabienne; McGouran, Joanna F; Century, Hannah; Gersch, Malte; Pittman, Marc S; Marshall, C Gary; Raynham, Tony M; Simcox, Mary; Stewart, Lorna M D; McLoughlin, Sheila B; Escobedo, Jaime A; Bair, Kenneth W; Dinsmore, Christopher J; Hammonds, Tim R; Kim, Sunkyu; Urbé, Sylvie; Clague, Michael J; Kessler, Benedikt M; Komander, David.

Nature ; 550(7677): 481-486, 2017 10 26.

Artículo en Inglés | MEDLINE | ID: mdl-29045389

3.

Methods for Intraocular Lens Power Calculation in Cataract Surgery after Radial Keratotomy.

Turnbull, Andrew M J; Crawford, Geoffrey J; Barrett, Graham D.

Ophthalmology ; 127(1): 45-51, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31561878

4.

Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.

Sachdev, Vinay; Leopold, Christina; Bauer, Raimund; Patankar, Jay V; Iqbal, Jahangir; Obrowsky, Sascha; Boverhof, Renze; Doktorova, Marcela; Scheicher, Bernhard; Goeritzer, Madeleine; Kolb, Dagmar; Turnbull, Andrew V; Zimmer, Andreas; Hoefler, Gerald; Hussain, M Mahmood; Groen, Albert K; Kratky, Dagmar.

Biochim Biophys Acta ; 1861(9 Pt A): 1132-1141, 2016 09.

Artículo en Inglés | MEDLINE | ID: mdl-27344248

5.

Discovery of potent inhibitors of the lysophospholipase autotaxin.

Shah, Pritom; Cheasty, Anne; Foxton, Caroline; Raynham, Tony; Farooq, Muddasar; Gutierrez, Irene Farre; Lejeune, Aurore; Pritchard, Michelle; Turnbull, Andrew; Pang, Leon; Owen, Paul; Boyd, Susan; Stowell, Alexandra; Jordan, Allan; Hamilton, Niall M; Hitchin, James R; Stockley, Martin; MacDonald, Ellen; Quesada, Mar Jimenez; Trivier, Elisabeth; Skeete, Jana; Ovaa, Huib; Moolenaar, Wouter H; Ryder, Hamish.

Bioorg Med Chem Lett ; 26(22): 5403-5410, 2016 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-27780639

6.

Selective Sampling of the Lower Airway in Children with Cystic Fibrosis: What Are We Missing?

Turnbull, Andrew; Hughes, Dominic; Davies, Jane.

Am J Respir Crit Care Med ; 201(6): 747-748, 2020 03 15.

Artículo en Inglés | MEDLINE | ID: mdl-31770011

7.

Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.

Liu, Li; Trent, Chad M; Fang, Xiang; Son, Ni-Huiping; Jiang, HongFeng; Blaner, William S; Hu, Yunying; Yin, Yu-Xin; Farese, Robert V; Homma, Shunichi; Turnbull, Andrew V; Eriksson, Jan W; Hu, Shi-Lian; Ginsberg, Henry N; Huang, Li-Shin; Goldberg, Ira J.

J Biol Chem ; 289(43): 29881-91, 2014 Oct 24.

Artículo en Inglés | MEDLINE | ID: mdl-25157099

8.

Reply.

Turnbull, Andrew M J; Barrett, Graham D.

Ophthalmology ; 127(10): e87-e88, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32739179

9.

Saturated gain spectrum of VECSELs determined by transient measurement of lasing onset.

Head, C Robin; Wilcox, Keith G; Turnbull, Andrew P; Morris, Oliver J; Shaw, Edward A; Tropper, Anne C.

Opt Express ; 22(6): 6919-24, 2014 Mar 24.

Artículo en Inglés | MEDLINE | ID: mdl-24664040

10.

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase (AKR1C3).

Flanagan, Jack U; Atwell, Graham J; Heinrich, Daniel M; Brooke, Darby G; Silva, Shevan; Rigoreau, Laurent J M; Trivier, Elisabeth; Turnbull, Andrew P; Raynham, Tony; Jamieson, Stephen M F; Denny, William A.

Bioorg Med Chem ; 22(3): 967-77, 2014 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-24411201

11.

Impact of T2R38 Receptor Polymorphisms on Pseudomonas aeruginosa Infection in Cystic Fibrosis.

Turnbull, Andrew R; Murphy, Ronan; Behrends, Volker; Lund-Palau, Helena; Simbo, Ameze; Mariveles, Myril; Alton, Eric W F W; Bush, Andrew; Shoemark, Amelia; Davies, Jane C.

Am J Respir Crit Care Med ; 197(12): 1635-1638, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29481289

12.

Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats.

Schober, Gudrun; Arnold, Myrtha; Birtles, Susan; Buckett, Linda K; Pacheco-López, Gustavo; Turnbull, Andrew V; Langhans, Wolfgang; Mansouri, Abdelhak.

J Lipid Res ; 54(5): 1369-84, 2013 May.

Artículo en Inglés | MEDLINE | ID: mdl-23449193

13.

ACAT-selective and nonselective DGAT1 inhibition: adrenocortical effects--a cross-species comparison.

Floettmann, Jan Eike; Buckett, Linda K; Turnbull, Andrew V; Smith, Tim; Hallberg, Carina; Birch, Alan; Lees, David; Jones, Huw B.

Toxicol Pathol ; 41(7): 941-50, 2013.

Artículo en Inglés | MEDLINE | ID: mdl-23427273

14.

Nitric oxide induces human CLA⁺CD25⁺Foxp3⁺ regulatory T cells with skin-homing potential.

Yu, Cunjing; Fitzpatrick, Amanda; Cong, Duanduan; Yao, Chengcan; Yoo, Jinah; Turnbull, Andrew; Schwarze, Jürgen; Norval, Mary; Howie, Sarah E M; Weller, Richard B; Astier, Anne L.

J Allergy Clin Immunol ; 140(5): 1441-1444.e6, 2017 11.

Artículo en Inglés | MEDLINE | ID: mdl-28601680

15.

Patient satisfaction and attitudes towards immediate sequential bilateral cataract surgery.

Campbell, Cara G; La, Chuiki J; Chan, Kim L; Turnbull, Andrew M J.

Eur J Ophthalmol ; 33(5): 1952-1958, 2023 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-36855280

16.

Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.

Ables, Gene P; Yang, Kryscilla Jian Zhang; Vogel, Silke; Hernandez-Ono, Antonio; Yu, Shuiqing; Yuen, Jason J; Birtles, Susan; Buckett, Linda K; Turnbull, Andrew V; Goldberg, Ira J; Blaner, William S; Huang, Li-Shin; Ginsberg, Henry N.

J Lipid Res ; 53(11): 2364-79, 2012 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-22911105

17.

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.

Pike, Ashley C W; Rellos, Peter; Niesen, Frank H; Turnbull, Andrew; Oliver, Antony W; Parker, Sirlester A; Turk, Benjamin E; Pearl, Laurence H; Knapp, Stefan.

EMBO J ; 27(4): 704-14, 2008 Feb 20.

Artículo en Inglés | MEDLINE | ID: mdl-18239682

18.

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

McCoull, William; Addie, Matthew S; Birch, Alan M; Birtles, Susan; Buckett, Linda K; Butlin, Roger J; Bowker, Suzanne S; Boyd, Scott; Chapman, Stephen; Davies, Robert D M; Donald, Craig S; Green, Clive P; Jenner, Chloe; Kemmitt, Paul D; Leach, Andrew G; Moody, Graeme C; Gutierrez, Pablo Morentin; Newcombe, Nicholas J; Nowak, Thorsten; Packer, Martin J; Plowright, Alleyn T; Revill, John; Schofield, Paul; Sheldon, Chris; Stokes, Steve; Turnbull, Andrew V; Wang, Steven J Y; Whalley, David P; Wood, J Matthew.

Bioorg Med Chem Lett ; 22(12): 3873-8, 2012 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-22608962

19.

Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.

Stockley, Martin L; Ferdinand, Amanda; Benedetti, Giovanni; Blencowe, Peter; Boyd, Susan M; Calder, Mat; Charles, Mark D; Edwardes, Lucy V; Ekwuru, Tennyson; Finch, Harry; Galbiati, Alessandro; Geo, Lerin; Grande, Diego; Grinkevich, Vera; Holliday, Nicholas D; Krajewski, Wojciech W; MacDonald, Ellen; Majithiya, Jayesh B; McCarron, Hollie; McWhirter, Claire L; Patel, Viral; Pedder, Chris; Rajendra, Eeson; Ranzani, Marco; Rigoreau, Laurent J M; Robinson, Helen M R; Schaedler, Theresia; Sirina, Julija; Smith, Graeme C M; Swarbrick, Martin E; Turnbull, Andrew P; Willis, Simon; Heald, Robert A.

J Med Chem ; 65(20): 13879-13891, 2022 10 27.

Artículo en Inglés | MEDLINE | ID: mdl-36200480

20.

DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle.

Liu, Li; Yu, Shuiqing; Khan, Raffay S; Ables, Gene P; Bharadwaj, Kalyani G; Hu, Yunying; Huggins, Lesley A; Eriksson, Jan W; Buckett, Linda K; Turnbull, Andrew V; Ginsberg, Henry N; Blaner, William S; Huang, Li-Shin; Goldberg, Ira J.

J Lipid Res ; 52(4): 732-44, 2011 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-21205704

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