Polarization-mismatching transmissive metasurface for independent amplitude and phase control of circular polarization.

This work presents a strategy for independent control of the amplitude and phase of transmissive circular-polarization (CP) waves. The designed meta-atom consists of an elliptical-polarization receiver and a CP transmitter. By changing the axial ratio (AR) and polarization of the receiver, amplitude modulation can be realized based on polarization mismatching theory, with negligible cumbrous components. While by rotating the element, a full phase coverage enabled by the geometric phase is achieved. Subsequently, a CP transmitarray antenna (TA) with high gain and low side-lobe level (SLL) is implemented to experimentally validate our strategy, and the tested results match well with the simulated ones. During the operating band from 9.6 to 10.4 GHz, the proposed TA obtains an average SLL of -24.5 dB, a lowest SLL of -27.7 dB at 9.9 GHz, and a maximum gain of 19 dBi at 10.3 GHz, with the measured AR lower than 1 dB, which mainly benefits from high polarization purity (HPP) of the proposed elements. The proposed strategy for full amplitude-phase manipulation of CP waves together with HPP paves a way for complicated field manipulations and indicates a promising candidate in antenna applications, such as anti-jamming systems and wireless communications.

Affinibrenneria salicis gen. nov. sp. nov. isolated from Salix matsudana bark canker.

L3-3HAT, a Gram-negative-staining, facultatively anaerobic, motile bacterial strain, was isolated from the symptomatic bark of Salix matsudana canker in China. 16S rRNA gene analysis revealed that the novel strain shares the highest sequence similarity with Brenneria goodwinii FRB141T (95.5%). In phylogenetic trees based on four housekeeping genes (gyrB, rpoB, atpD, and infB) and the 16S rRNA gene sequence, the novel strain formed a separate branch from the five genera of the family Pectobacteriaceae (Lonsdalea, Brenneria, Dickeya, Pectobacterium, and Sodalis), suggesting that the novel strain should belong to a novel species of a novel genus within the family Pectobacteriaceae. The result was also supported by phylogenomics, amino acid identity and average nucleotide identity. The major fatty acids were C14:0, C16:0, C17:0 cyclo, and C19:0 cyclo É·8c. Genome analysis showed that the novel strain has a large genome (5.89 Mb) with 5,052 coding genes, including 181 virulence genes by searching the pathogen-host interactions database (PHI-base), indicating that the novel strain is a potential pathogen of plants and animals. Based on phenotypic and genotypic characteristics, the L3-3HAT strain represents a novel species of a novel genus in the Pectobacteriaceae family, for which the name Affinibrenneria salicis gen nov. sp. nov. is proposed. The strain type is L3-3HAT (= CFCC 15588T = LMG 31209T).

The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating.

The cardiac mechanosensitive BK (Slo1) channels are gated by Ca2+, voltage, and membrane stretch. The neuropeptide GsMTx4 is a selective inhibitor of mechanosensitive (MS) channels. It has been reported to suppress stretch-induced cardiac fibrillation in the heart, but the mechanism underlying the specificity and even the targeting channel(s) in the heart remain elusive. Here, we report that GsMTx4 inhibits a stretch-activated BK channel (SAKcaC) in the heart through a modulation specific to mechano-gating. We show that membrane stretching increases while GsMTx4 decreases the open probability (Po) of SAKcaC. These effects were mostly abolished by the deletion of the STREX axis-regulated (STREX) exon located between RCK1 and RCK2 domains in BK channels. Single-channel kinetics analysis revealed that membrane stretch activates SAKcaC by prolonging the open-time duration (τO) and shortening the closed-time constant (τC). In contrast, GsMTx4 reversed the effects of membrane stretch, suggesting that GsMTx4 inhibits SAKcaC activity by interfering with mechano-gating of the channel. Moreover, GsMTx4 exerted stronger efficacy on SAKcaC under membrane-hyperpolarized/resting conditions. Molecular dynamics simulation study revealed that GsMTx4 appeared to have the ability to penetrate deeply within the bilayer, thus generating strong membrane deformation under the hyperpolarizing/resting conditions. Immunostaining results indicate that BK variants containing STREX are also expressed in mouse ventricular cardiomyocytes. Our results provide common mechanisms of peptide actions on MS channels and may give clues to therapeutic suppression of cardiac arrhythmias caused by excitatory currents through MS channels under hyper-mechanical stress in the heart.

Multi-functional coding metasurface for dual-band independent electromagnetic wave control.

Multi-functional metasurfaces have exhibited powerful abilities of manipulating electromagnetic (EM) wave in predetermined manners, largely improving their information capacities. However, most works are implemented with EM functions controlled by one of the intrinsic properties of EM wave, such as polarization, frequency, etc. Herein, we propose a coding scheme to design a broadband and high-efficient multi-functional metasurface independently controlled by both frequency and polarization. To achieve this goal, we design anisotropic coding particles to realize independent phase functions and polarization-selectivity in the microwave region. Meta-atoms are finally optimized to exhibit 2-bit phase responses insensitive to incident polarization in the X-band while showing a 1-bit phase shift sensitive to incident polarization in the Ku-band. As a proof of concept, a metasurface is configured as an isotropic lens in the X-band, whereas the metasurface is designed as an anisotropic beam deflector in the Ku-band with or without polarization-conversion functionality dependent on the input polarization. The measured results, which agree well with the simulated ones, show excellent performances in the designed dual bands. Such a multi-functional coding metasurface may provide a flexible and robust approach to manipulate EM wave of multiple frequencies, as well as to integrate diverse functionalities into a single flat device.

Polarization-independent broadband meta-surface for bifunctional antenna.

Functional integration is crucial and has become a research interest in recent years; however, available efforts suffer from low efficiency and narrow operating bandwidth. Here, we propose a novel strategy to design bifunctional meta-surface with high efficiency and largely enhanced bandwidth in reflection geometry. For demonstration, we designed and fabricated a bifunctional meta-surface which enables both focusing and anomalous reflection under different polarizations. The working bandwidth is significantly extended by using the dual-resonant three-turn meander-line resonator (TMLR) element which provides an almost consistent phase response within a large frequency interval. For potential applications, we engineered a bifunctional antenna by launching the designed meta-surface with proper feed sources. Numerical and experimental results coincide well, indicating bifunctionalities of high gain pencil-beam radiation (reflectarray) and beam steering radiation with comparable performances. Our results can stimulate the realizations of high-performance meta-surfaces and antenna systems.

Tunable Pancharatnam-Berry metasurface for dynamical and high-efficiency anomalous reflection.

Pancharatnam-Berry (PB) metasurfaces have intrigued a great deal of interest in recent years for anomalous reflection/refraction, vortex plate, orbital angular momentum, flat lens, photonic spin hall effect (PSHE), holograms and reflect/transmit arrays. However, almost all designs are restricted to fixed electrical performance/functionality once the design is finished. Here, we report for the first time a strategy for PB metasurface with agile working frequency by involving each meta-atom with tunable PIN diodes. For verification, a tunable PB metasurface with frequency reconfigurability is designed and numerically characterized across C and X band. By controlling the external voltages imposed on the diodes, numerical results show that the operation band with 180° phase difference between orthogonal reflection coefficients can be dynamically controlled. As such, the resulting PB metasurface composed of these orderly rotated meta-atoms exhibits a broadband PSHE with nearly 100% conversion efficiency in the "On" state while switches to dual well-separated bands in the "Off" state. Our proposal, not confined to PHSE, set a solid platform for PB phase control and can be populated to any dual-functional and/or multifunctional devices with high integrity, stability and low cost.

Syringo-Subarachnoid Shunt with Tube Versus T-Tube via the Dorsal Root Entry Zone Approach for Eccentric Syringomyelia.

OBJECTIVE: This study compared the clinical therapeutic efficacy of syringo-subarachnoid shunt placement with direct tube and T-tube via the dorsal root entry zone (DREZ) approach for treatment of eccentric syringomyelia. METHODS: A retrospective study was performed of 41 patients with idiopathic or secondary eccentric syringomyelia from November 2011 to December 2022. Syringo-subarachnoid shunt placement with direct tube or T-tube via the DREZ approach was performed. The modified Japanese Orthopaedic Association low back pain scale was used to investigate the severity of clinical symptoms. Magnetic resonance imaging was used to investigate therapeutic efficacy（reduction of the cavity volume by >10% was considered an improvement and 50% was considered a significant improvement). RESULTS: Incision length of the spinal cortex in the direct tube group was shorter than in the T-tube group (3.10 ± 0.28 cm vs. 5.03 ± 0.19 cm), with a significant difference between the 2 groups (t = -52.56, P < 0.001). Modified Japanese Orthopaedic Association score 3 months postoperatively was significantly better than the preoperative score in both the direct tube group（t = 40.954, P < 0.001） and the T-tube group（t = 24.769, P < 0.001）. Statistical comparison revealed there was no difference in imaging improvement between the direct tube group and T-tube group 3 months (χ2 = 0.20, P = 0.655) and 12 months (χ2 = 0.21, P = 0.647) postoperatively. CONCLUSIONS: Syringo-subarachnoid shunt placement with direct tube via the DREZ approach for treatment of eccentric syringomyelia is safer than with T-tube via the DREZ approach due to smaller incision length and less of a space-occupying effect with same therapeutic efficacy.

Compact dual-band circular polarizer using twisted Hilbert-shaped chiral metamaterial.

We propose a kind of chiral metamaterial inspired from the fractal concept. The Hilbert fractal perturbation in the twisted split ring resonator element results in compact metamaterial and breaking mirror symmetry, which readily forms chirality over triple bands. The discrepancy between co-polarization conversion and cross-polarization conversion over multiple bands can be explored for multifunctional devices. A multiband circular polarizer is then numerically and experimentally studied in the X band based on the bilayered twisted Hilbert resonator with mutual 90° rotation. The ability of transforming linearly polarized incident waves to circularly polarized waves is unambiguously demonstrated with high conversion efficiency and large polarization extinction ratio of more than 20 dB across dual bands. Moreover, exceptionally strong optical activity and circular dichroism are also observed.

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype.

Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about the immune landscape in peripheral circulation in patients with high-altitude pulmonary hypertension (HAPH). We apply single-cell transcriptomics to characterize the monocytes that are significantly enriched in the peripheral blood mononuclear cells (PBMC) of HAPH patients. We discover an increase in C1 (non-classical) and C2 (intermediate) monocytes in PBMCs and a decrease in hypoxia-inducible transcription factor-1α (HIF-1α) in all monocyte subsets associated with HAPH. In addition, we demonstrate that similar immune adaptations may exist in HAPH and PH. Overall, we characterize an immune cell atlas of the peripheral blood in HAPH patients. Our data provide evidence that specific monocyte subsets and HIF-1α downregulation might be implicated in the pathogenesis of HAPH.

Ultra-small single-negative electric metamaterials for electromagnetic coupling reduction of microstrip antenna array.

We report initially the design, fabrication and measurement of using waveguided electric metamaterials (MTM) in the design of closely-spaced microtrip antenna arrays with mutual coupling reduction. The complementary spiral ring resonators (CSRs) which exhibit single negative resonant permittivity around 3.5GHz are used as the basic electric MTM element. For verification, two CSRs with two and three concentric rings are considered, respectively. By properly arranging these well engineered waveguided MTMs between two H-plane coupled patch antennas, both numerical and measured results indicate that more than 8.4 dB mutual coupling reduction is obtained. The mechanism has been studied from a physical insight. The electric MTM element is electrically small, enabling the resultant antenna array to exhibit a small separation (λo/8 at the operating wavelength) and thus a high directivity. The proposed strategy opens an avenue to new types of antenna with super performances and can be generalized for other electric resonators.

[Exogenous hydrogen sulfide attenuates gastric ischemia-reperfusion injury via activation of K(ATP) channel].

The present study aimed to investigate the protective effect and mechanism of hydrogen sulfide donor NaHS administration against gastric mucosal injury induced by gastric ischemia-reperfusion (GI-R) in rats. GI-R injury was induced by clamping the celiac artery of adult male SD rats for 30 min and followed by reperfusion for 1 h. The rats were randomly divided into sham group, GI-R group, NaHS group, glibenclamide group and pinacidil group. Gastric mucosal damage was analyzed with macroscopic injured area, deep damage was assessed with histopathology scores, and the hydrogen sulfide concentration in plasma was determined by colorimetric method. The results showed that pretreatment of NaHS significantly reduced the injured area and deep damage of the gastric mucosa induced by GI-R. However, NaHS did not significantly alter the levels of hydrogen sulfide in plasma 14 d after NaHS administration. The gastric protective effect of NaHS during reperfusion could be attenuated by glibenclamide, an ATP-sensitive potassium channel (K(ATP)) blocker. However, K(ATP) opener pinacidil inhibited the GI-R-induced injury. These results suggest that exogenous hydrogen sulfide plays a protective role against GI-R injury in rats possibly through modulation of K(ATP) channel opening.

Mastoparan M extracted from Vespa magnifica alleviates neuronal death in global cerebral ischemia-reperfusion rat model.

Objectives: Global cerebral ischemia (GCI), a consequence of cardiac arrest (CA), can significantly damage the neurons located in the vulnerable hippocampus CA1 areas. Clinically, neurological injury after CA contributes to death in most patients. Mastoparan-M extracted from Vespa magnifica (Smith) can be used to treat major neurological disorders. Hence, this study aimed to assess the effects of Mastoparan-M on GCI. Materials and Methods: To evaluate the neurotoxicity and neuroprotective effect of Mastoparan-M, the CCK8 and Annexin V-FITC/PI apoptosis assays were first performed in hippocampal HT22 neuronal cells in vitro. Then, Pulsinelli's 4-vascular occlusion model was constructed in rats. After treatment with Mastoparan-M (0.05, 0.1, and 0.2 mg/kg, IP) for 3 or 7 days, behavioral tests, H&E staining or Nissl staining, immunohistochemistry, and ELISA were employed to investigate neuroprotective effects of Mastoparan-M on GCI in rats. Results: In vitro, the growth of HT22 neuronal cells was restrained at concentrations of 30-300 µg/ml (at 24 hr, IC50=105.2 µg/ml; at 48 hr, IC50=46.81 µg/ml), and Mastoparan-M treatment (0.1,1 and 5 µg/ml) restrained apoptosis. In vivo, Mastoparan-M improved neurocognitive function and neuronal loss in the hippocampal CA1 area of rats. In addition, these effects were associated with the prevention of neuroinflammation, oxidative stress, and apoptosis. Conclusion: Mastoparan-M acts as a neuroprotective agent to alleviate neuronal death in rats.

Effects of wasp venom on venous thrombosis in rats.

Objectives: This study aimed to investigate the potential effects of wasp venom (WV) from Vespa magnifica on antithrombosis in rats with inferior vena cava (IVC) thrombosis. Materials and Methods: The thrombosis rat model was established by improving the IVC stenosis, in which rats were subjected to IVC ligation for 75 min. Rats were administered argatroban (IP) or WV (s.c.) for 4 hr after IVC thrombosis. The weight, inhibition rate, and pathological morphology of the thrombosis induced by IVC ligation and the variation in four coagulation parameters, coagulation factors, and CD61+CD62P+ were simultaneously determined in IVC rats. Results: The thrombus formed as a result of IVC ligation was stable. Compared with the control group, the weight of the thrombus was significantly reduced in the argatroban group. Thrombus weight was reduced by treatment with 0.6, 0.2, and 0.05 mg/kg WV, with inhibition rates of 52.19%, 35.32%, and 28.98%, respectively. Inflammatory cells adhered to and infiltrated the vessel wall in the IVC group more than in the sham group. However, the pathological morphology and CD61+CD62P+ of the WV treatment groups tended to be normal. Conclusion: We improved the model of IVC thrombosis to be suitable for evaluation of antithrombotic drugs. Our findings demonstrated that WV could inhibit IVC thrombosis associated with reducing coagulation factors V and CD61+CD62p expression in rats.

Dynamic Changes of Volatile Compounds during the Xinyang Maojian Green Tea Manufacturing at an Industrial Scale.

Xinyang Maojian (XYMJ) is one of the premium green teas and originates from Xinyang, which is the northernmost green tea production area in China. The special geographic location, environmental conditions, and manufacturing process contribute to the unique flavor and rich nutrition of XYMJ green tea. Aroma is an important quality indicator in XYMJ green tea. In order to illustrate the aroma of XYMJ green tea, the key odorants in XYMJ green tea and their dynamic changes during the manufacturing processes were analyzed by headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC-MS). A total of 73 volatile compounds of six different chemical classes were identified in the processed XYMJ green tea samples, and the manufacturing processes resulted in the losses of total volatile compounds. Among the identified volatile compounds, twenty-four aroma-active compounds, such as trans-nerolidol, geranylacetone, nonanal, (+)-δ-cadinene, linalool, (Z)-jasmone, cis-3-hexenyl butyrate, cis-3-hexenyl hexanoate, methyl jasmonate, and ß-ocimene, were identified as the key odorants of XYMJ green tea based on odor activity value (OAV). The key odorants are mainly volatile terpenes (VTs) and fatty acid-derived volatiles (FADVs). Except for (+)-δ-cadinene, copaene, cis-ß-farnesene, (Z,E)-α-farnesene and phytol acetate, the key odorants significantly decreased after fixing. The principal coordinate analysis (PCoA) and the hierarchical cluster analysis (HCA) analyses suggested that fixing was the most important manufacturing process for the aroma formation of XYMJ green tea. These findings of this study provide meaningful information for the manufacturing and quality control of XYMJ green tea.

[Alternatively activated macrophages in helminth infections].

Macrophages not only initiate and modulate immune responses, but also are the final effector cells. Recent studies suggested that macrophages conventionally associated with IFN-gamma dominant Th1-type responses and also playing an essential role in the Th2-type inflammatory response, exhibit a quite different activation from the classically activated macrophages (CAM Phi) stimulated during Th1-type responses, therefore named as alternatively activated macrophages (AAM Phi). AAM Phi have multiple effects during helminth infection, including control of inflammatory reaction, contribution to fibrosis and repair at the site of injury, and anti-helminth effect. This article reviews recent findings regarding the role of AAM Phi in the development of disease and host protection following helminth infection.

Test and Numerical Model of Curved Steel-Concrete Composite Box Beams under Positive Moments.

Compared with straight steel-concrete composite beams, curved composite beams exhibit more complicated mechanical behaviors under combined bending and torsion coupling. There are much fewer experimental studies on curved composite beams than those of straight composite beams. This study aimed to investigate the combined bending and torsion behavior of curved composite beams. This paper presents static loading tests of the full elastoplastic process of three curved composite box beams with various central angles and shear connection degrees. The test results showed that the specimens exhibited notable bending and torsion coupling force characteristics under static loading. The curvature and interface shear connection degree significantly affected the force behavior of the curved composite box beams. The specimens with weak shear connection degrees showed obvious interfacial longitudinal slip and transverse slip. Constraint distortion and torsion behavior caused the strain of the inner side of the structure to be higher than the strain of the outer side. The strain of the steel beam webs was approximately linear. In addition, fine finite element models of three curved composite box beams were established. The correctness and applicability of the finite element models were verified by comparing the test results and numerical calculation results for the load-displacement curve, load-rotational angle curve, load-interface slip curve, and cross-sectional strain distribution. Finite element modeling can be used as a reliable numerical tool for the large-scale parameter analysis of the elastic-plastic mechanical behavior of curved composite box beams.

Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons.

Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons. Here, we report and characterize a lncRNA, termed Brain Specific DNA-damage Related lncRNA1 (BS-DRL1), in the central nervous system. BS-DRL1 is a brain-specific lncRNA and depletion of BS-DRL1 in neurons leads to impaired DDR upon etoposide treatment in vitro. Mechanistically, BS-DRL1 interacts with HMGB1, a chromatin protein that is important for genome stability, and is essential for the assembly of HMGB1 on chromatin. BS-DRL1 mediated DDR exhibits cell-type specificity in the cortex and cerebellum in gamma-irradiated mice and BS-DRL1 knockout mice show impaired motor function and concomitant purkinje cell degeneration. Our study extends the understanding of lncRNAs in DDR and genome stability and implies a protective role of lncRNA against neurodegeneration.

Finite Beam Element for Curved Steel-Concrete Composite Box Beams Considering Time-Dependent Effect.

Curved steel-concrete composite box beams are widely used in urban overpasses and ramp bridges. In contrast to straight composite beams, curved composite box beams exhibit complex mechanical behavior with bending-torsion coupling, including constrained torsion, distortion, and interfacial biaxial slip. The shear-lag effect and curvature variation in the radial direction should be taken into account when the beam is sufficiently wide. Additionally, long-term deflection has been observed in curved composite box beams due to the shrinkage and creep effects of the concrete slab. In this paper, an equilibrium equation for a theoretical model of curved composite box beams is proposed according to the virtual work principle. The finite element method is adopted to obtain the element stiffness matrix and nodal load matrix. The age-adjusted effective modulus method is introduced to address the concrete creep effects. This 26-DOF finite beam element model is able to simulate the constrained torsion, distortion, interfacial biaxial slip, shear lag, and time-dependent effects of curved composite box beams and account for curvature variation in the radial direction. An elaborate finite element model of a typical curved composite box beam is established. The correctness and applicability of the proposed finite beam element model is verified by comparing the results from the proposed beam element model to those from the elaborate finite element model. The proposed beam element model is used to analyze the long-term behavior of curved composite box beams. The analysis shows that significant changes in the displacement, stress and shear-lag coefficient occur in the curved composite beams within the first year of loading, after which the variation tendency becomes gradual. Moreover, increases in the central angle and shear connection stiffness both reduce the change rates of displacement and stress with respect to time.

Cerebral infarct secondary to traumatic internal carotid artery dissection.

BACKGROUND: Traumatic internal carotid artery dissection (TICAD) is rare and can result in severe neurological disability and even death. No consensus regarding its diagnostic screening and management has been established. AIM: To investigate the clinical presentation, imaging features, diagnostic workup, and treatment of TICAD. METHODS: In this retrospective case series, emergency admissions for TICAD due to closed head injury were analyzed. The demographic, clinical, and radiographic data were retrieved from patient charts and the picture archiving and communication system. RESULTS: Six patients (five males and one female, age range of 43-62 years, mean age of 52.67 years) presented with TICAD. Traffic accidents (4/6) were the most frequent cause of TICAD. The clinical presentation was always related to brain hypoperfusion. Imaging examination revealed dissection of the affected artery and corresponding brain infarction. All the patients were definitively diagnosed with TICAD. One patient was treated conservatively, one patient underwent anticoagulant therapy, two patients were given both antiplatelet and anticoagulant drugs, and two patients underwent decompressive craniectomy. One patient fully recovered, while three patients were disabled at follow-up. Two patients died of refractory brain infarction. CONCLUSION: TICAD can cause catastrophic outcomes and even refractory brain hernia. Early and efficient diagnosis of TICAD is essential for initiating appropriate treatment. The treatment of TICAD is challenging and variable and is based on clinician discretion on a case-by-case basis.

Experimental Research of the Time-Dependent Effects of Steel-Concrete Composite Girder Bridges during Construction and Operation Periods.

The present work aimed to study the effects of temperature changes and concrete creep on I-shaped steel-concrete composite continuous girder bridges during construction and operation processes. This study combined structural health monitoring data, an ANSYS finite element simulation, and the age-adjusted effective modulus method to obtain the variation laws of temperature and internal force in composite girders. Moreover, a temperature gradient model was proposed that is suitable for bridges in Hebei, China. In addition, a concrete creep experiment under unidirectional axial compression was performed using concrete specimens prepared from the concrete batch used to create the composite girder. The long-term evolution laws of the deflection and internal force of the composite girder were obtained by predicting the concrete creep effect. The measured data showed that the temperature variation trends of the steel beam and concrete slab were characterized by a sinusoidal curve without a temperature lag. The heating rate of the concrete slab was higher than the cooling rate. The prediction results showed that the internal force changes in the composite girder were characterized by three stages. The stress changes in the composite girder during the first 10 days were significant and the stress charge rate of the concrete slab, the steel girder and the shear stud can reach 5%-28%. The stress change rate decreased continuously during 10-90 days. The stress changed slowly and smoothly after 90 days. This research can provide feedback and reference for structural health monitoring and service safety control of similar I-shaped steel-concrete composite bridges.