Demonstration of using two aperture pairs combined with multiple-mode receivers and MIMO signal processing for enhanced tolerance to turbulence and misalignment in a 10 Gbit/s QPSK FSO link.

We utilize aperture diversity combined with multiple-mode receivers and multiple-input-multiple-output (MIMO) digital signal processing (DSP) to demonstrate enhanced tolerance to atmospheric turbulence and spatial misalignment in a 10 Gbit/s quadrature-phase-shift-keyed (QPSK) free-space optical (FSO) link. Turbulence and misalignment could cause power coupling from the fundamental Gaussian mode into higher-order modes. Therefore, we detect power from multiple modes and use MIMO DSP to enhance the recovery of the original data. In our approach, (a) each of multiple transmitter apertures transmits a single fundamental Gaussian beam carrying the same data stream, (b) each of multiple receiver apertures detects the signals that are coupled from the fundamental Gaussian beams to multiple orbital angular momentum (OAM) modes, and (c) MIMO DSP is used to recover the data over multiple modes and receivers. Our simulation shows that the outage probability could be reduced from >0.1 to <0.01. Moreover, we experimentally demonstrate the scheme by transmitting two fundamental Gaussian beams carrying the same data stream and recovering the signals on OAM modes 0 and +1 at each receiver aperture. We measure an up to ∼10dB power-penalty reduction for a bit error rate (BER) at the 7% forward error correction limit for a 10 Gbit/s QPSK signal.

Simultaneous turbulence mitigation and channel demultiplexing for two 100 Gbit/s orbital-angular-momentum multiplexed beams by adaptive wavefront shaping and diffusing.

We experimentally demonstrate simultaneous turbulence mitigation and channel demultiplexing in a 200 Gbit/s orbital-angular-momentum (OAM) multiplexed link by adaptive wavefront shaping and diffusing (WSD) the light beams. Different realizations of two emulated turbulence strengths (the Fried parameter ${r_0} = 0.4,\,1.0\;{\rm mm}$r0=0.4,1.0mm) are mitigated. The experimental results show the following. (1) Crosstalk between OAM $l = + 1$l=+1 and $l = - 1$l=-1 modes can be reduced by $ {\gt} {10.0}$>10.0 and $ {\gt} {5.8}\;{\rm dB}$>5.8dB, respectively, under the weaker turbulence (${r_0} = 1.0\;{\rm mm}$r0=1.0mm); crosstalk is further improved by $ {\gt} {17.7}$>17.7 and $ {\gt} {19.4}\;{\rm dB}$>19.4dB, respectively, under most realizations in the stronger turbulence (${r_0} = 0.4\;{\rm mm}$r0=0.4mm). (2) The optical signal-to-noise ratio penalties for the bit error rate performance are measured to be ${\sim}{0.7}$∼0.7 and ${\sim}{1.6}\;{\rm dB}$∼1.6dB under weaker turbulence, while measured to be ${\sim}{3.2}$∼3.2 and ${\sim}{1.8}\;{\rm dB}$∼1.8dB under stronger turbulence for OAM $l = + 1$l=+1 and $l = - 1$l=-1 mode, respectively.

Reconfigurable optical generation of nine Nyquist WDM channels with sinc-shaped temporal pulse trains using a single microresonator-based Kerr frequency comb.

Sinc-shaped temporal pulse trains have a spectrally efficient, rectangular Nyquist spectrum. We demonstrate the simultaneous and reconfigurable optical generation of multiple Nyquist-shaped wavelength-division-multiplexed (WDM) channels having temporal sinc-shaped pulse trains as data carriers. The channels are generated through the insertion of coherent lines using cascaded continuous-wave amplitude modulation around the spectral lines of a microresonator-based Kerr optical frequency comb. For each of nine Kerr frequency comb lines, we insert sub-groups of uniform and coherent lines to generate nine WDM channels. The deviations from ideal Nyquist pulses for the nine channels at repetition rates of 6 and 2 GHz are between 4.2%-6.1% and 2%-4.5%, respectively. Each WDM channel is modulated with on-off keying (OOK) at 6 Gbit/s. In addition, we show the reconfigurability of this method by varying the number of WDM channels, the generated sinc-shaped pulse train repetition rates, the duration, and the number of zero-crossings.

Coherent optical wireless communication link employing orbital angular momentum multiplexing in a ballistic and diffusive scattering medium.

We experimentally investigate the scattering effect on an 80 Gbit/s orbital angular momentum (OAM) multiplexed optical wireless communication link. The power loss, mode purity, cross talk, and bit error rate performance are measured and analyzed for different OAM modes under scattering levels from ballistic to diffusive regions. Results show that (i) power loss is the main impairment in the ballistic scattering, while the mode purities of different OAM modes are not significantly affected; (ii) in the diffusive scattering, however, the performance of an OAM-multiplexed link further suffers from the increased cross talk between the different OAM modes.

Performance enhancement of an optical high-order QAM channel by adding correlated data to robust neighboring BPSK or QPSK channels.

We numerically simulate and experimentally demonstrate an approach to potentially enhance the performance of a high-order quadrature amplitude modulation (QAM) channel by adding correlated data to other robust binary-phase-shift-keyed (BPSK) or quadrature-phase-shift-keyed (QPSK) channels. The correlated data are introduced by optically multiplying the BPSK or QPSK channels, already modulated with their own data, by the target high-order QAM data of the same baud rate. After joint detection and signal processing, a ∼3 dB optical signal-to-noise (OSNR) improvement is observed in simulations by comparing the performance of the target QAM channel (from 4QAM to 256QAM) with and without the use of channel correlation. We also experimentally demonstrate the scheme for a QPSK or a 16QAM target channel using BPSK correlated channels. A ≥2 dB OSNR improvement is observed.

Scalable and reconfigurable optical tapped-delay-line for multichannel equalization and correlation using nonlinear wave mixing and a Kerr frequency comb.

We experimentally demonstrate a scalable and reconfigurable optical tapped-delay-line (TDL) for multichannel equalization and correlation of 20-Gbaud quadrature-phase-shift-keyed (QPSK) signals using nonlinear wave mixing and a microresonator Kerr frequency comb. The optical TDL mainly consists of two stages: one being a multicasting of the original signals in a periodically poled lithium niobate (PPLN) waveguide with Kerr comb lines functioning as mutually coherent pumps, while the other is a coherent multiplexing of the delayed and weighted signal replicas in a second PPLN. A two- or three-tap optical TDL is demonstrated to simultaneously equalize a distorted QPSK data signal, reducing the error vector magnitude (EVM) from 22.5% to either 19.9% or 18.2%, and search two- or three-symbol patterns on another QPSK signal.

Demonstration of a 10 Mbit/s quantum communication link by encoding data on two Laguerre-Gaussian modes with different radial indices.

We experimentally demonstrate a 10 Mbit/s free-space quantum communication link using data encoding on orthogonal Laguerre-Gaussian (LG) modes with the same azimuthal index but different radial indices. Data encoding on two LGℓp modes (i.e., for ℓ=0, we encode ["0", "1"] as [p=0, p=1], and for ℓ=1, we encode ["0", "1"] as [p=0, p=1]) is demonstrated by employing directly modulated laser diodes and helical phase holograms. The quantum symbol error rate (QSER) of <5% is achieved at an encoding rate of 10 Mbit/s. Moreover, the influence of the circle radius (R) of the receiver phase pattern on registered photon rates and QSERs is investigated. Our results show that a receiver phase pattern whose R does not match the beam size of the LG modes would induce higher cross talk between the two encoded quantum branches.

Single molecule characterization of individual extracellular vesicles from pancreatic cancer.

Biofluid-accessible extracellular vesicles (EVs) may represent a new means to improve the sensitivity and specificity of detecting disease. However, current methods to isolate EVs encounter challenges when they are used to select specific populations. Moreover, it has been difficult to comprehensively characterize heterogeneous EV populations at the single vesicle level. Here, we robustly assessed heterogeneous EV populations from cultured cell lines via nanoparticle tracking analysis, proteomics, transcriptomics, transmission electron microscopy, and quantitative single molecule localization microscopy (qSMLM). Using qSMLM, we quantified the size and biomarker content of individual EVs. We applied qSMLM to patient plasma samples and identified a pancreatic cancer-enriched EV population. Our goal is to advance single molecule characterization of EVs for early disease detection. Abbreviations: EV: Extracellular Vesicle; qSMLM: quantitative Single Molecule Localization Microscopy; PDAC: Pancreatic Ductal Adenocarcinoma; EGFR: epidermal growth factor receptor 1; CA19-9: carbohydrate antigen 19-9; SEC: size exclusion chromatography; WGA: wheat germ agglutinin; AF647: Alexa Fluor 647; Ab: antibody; HPDEC: Healthy Pancreatic Ductal Epithelial Cell; TEM: Transmission Electron Microscopy.

Single-End Adaptive Optics Compensation for Emulated Turbulence in a Bi-Directional 10-Mbit/s per Channel Free-Space Quantum Communication Link Using Orbital-Angular-Momentum Encoding.

A single-end adaptive-optics (AO) module is experimentally demonstrated to mitigate the emulated atmospheric turbulence effects in a bi-directional quantum communication link, which employs orbital angular momentum (OAM) for data encoding. A classical Gaussian beam is used as a probe to detect the turbulence-induced wavefront distortion in the forward direction of the link. Based on the detected wavefront distortion, an AO system located on one end of the link is used to simultaneously compensate for the forward and backward channels. Specifically, with emulated turbulence and when the probe is turned on, the mode purity of photons carrying OAM ℓ = 1 is improved by ~ 21 % with AO mitigation. We also measured the performance when encoding data using OAM {ℓ = -1, + 2} and {ℓ = -2, + 1} in the forward and backward channels, respectively, at 10 Mbit/s per channel with one photon per pulse on average. For this case, we found that the AO system could reduce the turbulence effects increased quantum-symbol-error-rate (QSER) by ~ 76 % and ~ 74 %, for both channels in the uni-directional and bi-directional cases, respectively. Similar QSER improvement is observed for the opposite direction channels in the bi-directional case.