1.
Br J Haematol
; 198(2): 328-332, 2022 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35509237
RESUMEN
Depth of response is the critical determinant of prognosis in amyloid light-chain (AL) amyloidosis. Here, we aim to identify patients who are unlikely to improve response based on analysis of baseline characteristics and 1-month response. In a multivariate model, difference in involved amyloidogenic and uninvolved serum free light chains (dFLC) at diagnosis (dFLC >400 mg/l, odds ratio [OR] 4.051, p < 0.005) and no response at 1 month (OR 4.787, p < 0.005) were significant predictors of no improvement in response. Only 5% of patients with a dFLC of >400 mg/l and no response at 1 month improved their response (p < 0.005). We suggest that these patients should switch treatment early, subject to their functional status.
Asunto(s)
Amiloidosis , Amiloidosis de Cadenas Ligeras de las Inmunoglobulinas , Algoritmos , Amiloidosis/diagnóstico , Amiloidosis/terapia , Consenso , Humanos , Cadenas Ligeras de Inmunoglobulina , Amiloidosis de Cadenas Ligeras de las Inmunoglobulinas/diagnóstico , Amiloidosis de Cadenas Ligeras de las Inmunoglobulinas/terapia , Reino Unido
2.
Am J Hematol
; 97(12): E444-E446, 2022 12.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36088630
3.
Leukemia
; 36(4): 1180-1184, 2022 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34987193