RESUMEN
Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new ß-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC50 values of 18.41, 0.30, 19.55, and 10.50 µM, respectively.
Asunto(s)
Alcaloides/aislamiento & purificación , Alcaloides/farmacología , Antiinflamatorios no Esteroideos/aislamiento & purificación , Antiinflamatorios no Esteroideos/farmacología , Carbolinas/aislamiento & purificación , Carbolinas/farmacología , Lauraceae/química , Sesquiterpenos/aislamiento & purificación , Sesquiterpenos/farmacología , Alcaloides/química , Antiinflamatorios no Esteroideos/química , Carbolinas/química , Relación Dosis-Respuesta a Droga , Concentración 50 Inhibidora , Isoflavonas/química , Isoflavonas/aislamiento & purificación , Lipopolisacáridos/farmacología , Estructura Molecular , FN-kappa B/efectos de los fármacos , Óxido Nítrico Sintasa de Tipo II/efectos de los fármacos , Raíces de Plantas/química , Sesquiterpenos/químicaRESUMEN
Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallylcatechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 2.1, and 5.3 µM, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H37Rv, with MIC values of 30.3, 27.6, and 25.5 µg/mL, respectively.