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1.

Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.

Sikorska, Justyna; Hou, Yan; Chiurazzi, Paul; Siu, Tony; Baltus, Gretchen A; Sheth, Payal; McLaren, David G; Truong, Quang; Parish, Craig A; Wyss, Daniel F.

Nucleic Acids Res ; 51(17): 9356-9368, 2023 09 22.

Artículo en Inglés | MEDLINE | ID: mdl-37486777

2.

Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.

Wyss, Daniel F; Wang, Yu-Sen; Eaton, Hugh L; Strickland, Corey; Voigt, Johannes H; Zhu, Zhaoning; Stamford, Andrew W.

Top Curr Chem ; 317: 83-114, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-21647837

3.

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Chang, Wonsuk; Altman, Michael D; Lesburg, Charles A; Perera, Samanthi A; Piesvaux, Jennifer A; Schroeder, Gottfried K; Wyss, Daniel F; Cemerski, Saso; Chen, Yiping; DiNunzio, Edward; Haidle, Andrew M; Ho, Thu; Kariv, Ilona; Knemeyer, Ian; Kopinja, Johnny E; Lacey, Brian M; Laskey, Jason; Lim, Jongwon; Long, Brian J; Ma, Yanhong; Maddess, Matthew L; Pan, Bo-Sheng; Presland, Jeremy P; Spooner, Edward; Steinhuebel, Dietrich; Truong, Quang; Zhang, Zhibo; Fu, Jianmin; Addona, George H; Northrup, Alan B; Parmee, Emma; Tata, James R; Bennett, David Jonathan; Cumming, Jared N; Siu, Tony; Trotter, B Wesley.

J Med Chem ; 65(7): 5675-5689, 2022 04 14.

Artículo en Inglés | MEDLINE | ID: mdl-35332774

4.

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.

Mandal, Mihirbaran; Xiao, Li; Pan, Weidong; Scapin, Giovanna; Li, Guoqing; Tang, Haiqun; Yang, Shu-Wei; Pan, Jianping; Root, Yuriko; de Jesus, Reynalda Keh; Yang, Christine; Prosise, Winnie; Dayananth, Priya; Mirza, Asra; Therien, Alex G; Young, Katherine; Flattery, Amy; Garlisi, Charles; Zhang, Rumin; Chu, Donald; Sheth, Payal; Chu, Inhou; Wu, Jin; Markgraf, Carrie; Kim, Hai-Young; Painter, Ronald; Mayhood, Todd W; DiNunzio, Edward; Wyss, Daniel F; Buevich, Alexei V; Fischmann, Thierry; Pasternak, Alexander; Dong, Shuzhi; Hicks, Jacqueline D; Villafania, Artjohn; Liang, Lianzhu; Murgolo, Nicholas; Black, Todd; Hagmann, William K; Tata, Jim; Parmee, Emma R; Weber, Ann E; Su, Jing; Tang, Haifeng.

J Med Chem ; 65(24): 16234-16251, 2022 12 22.

Artículo en Inglés | MEDLINE | ID: mdl-36475645

5.

An orally available non-nucleotide STING agonist with antitumor activity.

Pan, Bo-Sheng; Perera, Samanthi A; Piesvaux, Jennifer A; Presland, Jeremy P; Schroeder, Gottfried K; Cumming, Jared N; Trotter, B Wesley; Altman, Michael D; Buevich, Alexei V; Cash, Brandon; Cemerski, Saso; Chang, Wonsuk; Chen, Yiping; Dandliker, Peter J; Feng, Guo; Haidle, Andrew; Henderson, Timothy; Jewell, James; Kariv, Ilona; Knemeyer, Ian; Kopinja, Johnny; Lacey, Brian M; Laskey, Jason; Lesburg, Charles A; Liang, Rui; Long, Brian J; Lu, Min; Ma, Yanhong; Minnihan, Ellen C; O'Donnell, Greg; Otte, Ryan; Price, Laura; Rakhilina, Larissa; Sauvagnat, Berengere; Sharma, Sharad; Tyagarajan, Sriram; Woo, Hyun; Wyss, Daniel F; Xu, Serena; Bennett, David Jonathan; Addona, George H.

Science ; 369(6506)2020 08 21.

Artículo en Inglés | MEDLINE | ID: mdl-32820094

6.

NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.

Hou, Yan; Mayhood, Todd; Sheth, Payal; Tan, Christopher M; Labroli, Marc; Su, Jing; Wyss, Daniel F; Roemer, Terry; McCoy, Mark A.

J Biomol Screen ; 21(6): 579-89, 2016 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-27028606

7.

NMR screening in fragment-based drug design: a practical guide.

Kim, Hai-Young; Wyss, Daniel F.

Methods Mol Biol ; 1263: 197-208, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-25618347

8.

Double-stranded DNA-induced localized unfolding of HCV NS3 helicase subdomain 2.

Liu, Dingjiang; Windsor, William T; Wyss, Daniel F.

Protein Sci ; 12(12): 2757-67, 2003 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-14627736

9.

Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications.

Wang, Yu-Sen; Youngster, Stephen; Grace, Michael; Bausch, James; Bordens, Ronald; Wyss, Daniel F.

Adv Drug Deliv Rev ; 54(4): 547-70, 2002 Jun 17.

Artículo en Inglés | MEDLINE | ID: mdl-12052714

10.

Structure, biology, and therapeutic implications of pegylated interferon alpha-2b.

Youngster, Stephen; Wang, Yu-Sen; Grace, Michael; Bausch, James; Bordens, Ronald; Wyss, Daniel F.

Curr Pharm Des ; 8(24): 2139-57, 2002.

Artículo en Inglés | MEDLINE | ID: mdl-12369859

11.

NMR-based approaches for lead discovery.

Wyss, Daniel F; McCoy, Mark A; Senior, Mary M.

Curr Opin Drug Discov Devel ; 5(4): 630-47, 2002 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-12197321

12.

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Wyss, Daniel F; Arasappan, Ashok; Senior, Mary M; Wang, Yu-Sen; Beyer, Brian M; Njoroge, F George; McCoy, Mark A.

J Med Chem ; 47(10): 2486-98, 2004 May 06.

Artículo en Inglés | MEDLINE | ID: mdl-15115392

13.

Effective progression of nuclear magnetic resonance-detected fragment hits.

Eaton, Hugh L; Wyss, Daniel F.

Methods Enzymol ; 493: 447-68, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-21371601

14.

Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.

Huang, Xiaohua; Shipps, Gerald W; Cheng, Cliff C; Spacciapoli, Peter; Zhang, Xingmin; McCoy, Mark A; Wyss, Daniel F; Yang, Xianshu; Achab, Abdelghani; Soucy, Kyle; Montavon, Donna K; Murphy, Denise M; Whitehurst, Charles E.

ACS Med Chem Lett ; 2(8): 632-7, 2011 Aug 11.

Artículo en Inglés | MEDLINE | ID: mdl-24900358

15.

Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase.

Cheng, Cliff C; Huang, Xiaohua; Shipps, Gerald W; Wang, Yu-Sen; Wyss, Daniel F; Soucy, Kyle A; Jiang, Chuan-Kui; Agrawal, Sony; Ferrari, Eric; He, Zhiqing; Huang, H-C.

ACS Med Chem Lett ; 1(9): 466-71, 2010 Dec 09.

Artículo en Inglés | MEDLINE | ID: mdl-24900232

16.

Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.

Zhu, Zhaoning; Sun, Zhong-Yue; Ye, Yuanzan; Voigt, Johannes; Strickland, Corey; Smith, Elizabeth M; Cumming, Jared; Wang, Lingyan; Wong, Jesse; Wang, Yu-Sen; Wyss, Daniel F; Chen, Xia; Kuvelkar, Reshma; Kennedy, Matthew E; Favreau, Leonard; Parker, Eric; McKittrick, Brian A; Stamford, Andrew; Czarniecki, Michael; Greenlee, William; Hunter, John C.

J Med Chem ; 53(3): 951-65, 2010 Feb 11.

Artículo en Inglés | MEDLINE | ID: mdl-20043696

17.

Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.

Wang, Yu-Sen; Strickland, Corey; Voigt, Johannes H; Kennedy, Matthew E; Beyer, Brian M; Senior, Mary M; Smith, Elizabeth M; Nechuta, Terry L; Madison, Vincent S; Czarniecki, Michael; McKittrick, Brian A; Stamford, Andrew W; Parker, Eric M; Hunter, John C; Greenlee, William J; Wyss, Daniel F.

J Med Chem ; 53(3): 942-50, 2010 Feb 11.

Artículo en Inglés | MEDLINE | ID: mdl-20043700

18.

Structure-guided applications in drug discovery.

Wyss, Daniel F.

Drug Discov Today ; 8(20): 924-6, 2003 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-14554155

19.

Screening of protein kinases by ATP-STD NMR spectroscopy.

McCoy, Mark A; Senior, Mary M; Wyss, Daniel F.

J Am Chem Soc ; 127(22): 7978-9, 2005 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-15926798

20.

Characterization of autocatalytic conversion of precursor BACE1 by heteronuclear NMR spectroscopy.

Wang, Yu-Sen; Beyer, Brian M; Senior, Mary M; Wyss, Daniel F.

Biochemistry ; 44(50): 16594-601, 2005 Dec 20.

Artículo en Inglés | MEDLINE | ID: mdl-16342950

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