RESUMEN
Artensunate transdermal preparation at 5, 10, or 15 mg/kg, bid, for 3 days applied locally on the shaved skin of the back of monkeys showed reliable therapeutic effects on Plasmodium cynomolgi, but recrudescence of the parasites was not controlled. If some azone was added in the artesunate transdermal preparation at the dosage of 5 mg/kg, bid, for 3 days, the parasitemia of Plasmodium cynomolgi could be cleared and recrudescence prevented, thus, the antimalarial effects was enhanced.
Asunto(s)
Antimaláricos/uso terapéutico , Artemisininas , Malaria/tratamiento farmacológico , Sesquiterpenos/uso terapéutico , Administración Cutánea , Animales , Antimaláricos/administración & dosificación , Artesunato , Azepinas/administración & dosificación , Sinergismo Farmacológico , Macaca mulatta , Masculino , Plasmodium , Sesquiterpenos/administración & dosificaciónRESUMEN
This paper introduces the use of optimized solvent system with twice-ascending-development in twin trough chamber on TLC silica gel plate for the separation of protoberberine-type alkaloids contained in Rhizomata of Coptis spp. Nine to eleven spots including the main and the 'minor' alkaloids in the samples can be observed on the chromatograms obtained under controlled conditions. The fluorescence and UV-absorption TLC scanning profile can serve as fingerprint for the analysis of commercial samples of Rhizomata of Coptis spp.