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1.
Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage.
Mol Ther
; 31(4): 1106-1122, 2023 04 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36694463
2.
Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice.
J Pharmacol Exp Ther
; 384(1): 197-204, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36273821
3.
Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives.
Biopharm Drug Dispos
; 44(1): 26-47, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36336817
4.
Utility of hairless rats as a model for predicting transdermal pharmacokinetics in humans.
Xenobiotica
; 50(7): 831-838, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-31814485
5.
Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.
Pharm Res
; 36(5): 76, 2019 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30937626
6.
Impact of P-Glycoprotein on Intestinal Absorption of an Inhibitor of Apoptosis Protein Antagonist in Rats: Mechanisms of Nonlinear Pharmacokinetics and Food Effects.
Pharm Res
; 35(10): 190, 2018 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30105478
7.
Utility of Göttingen minipigs for Prediction of Human Pharmacokinetic Profiles After Dermal Drug Application.
Pharm Res
; 34(11): 2415-2424, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28828717
8.
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.
Bioorg Med Chem
; 24(11): 2486-503, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27112449
9.
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test.
Bioorg Med Chem
; 24(11): 2504-18, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27117261
10.
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challenges.
Drug Metab Pharmacokinet
; 56: 101003, 2024 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38843652
11.
Novel Cell Quantification Method Using a Single Surrogate Calibration Curve Across Various Biological Samples.
AAPS J
; 25(2): 26, 2023 02 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36806998
12.
Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain.
J Control Release
; 357: 379-393, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37031741
13.
Brain microvascular endothelial cells derived from human induced pluripotent stem cells as in vitro model for assessing blood-brain barrier transferrin receptor-mediated transcytosis.
Mater Today Bio
; 14: 100232, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35308041
14.
Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals.
J Biol Chem
; 285(9): 6522-31, 2010 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20042597
15.
Highly specific, quantitative polymerase chain reaction probe for the quantification of human cells in cynomolgus monkeys.
Drug Metab Pharmacokinet
; 36: 100359, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33348238
16.
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration.
Drug Metab Pharmacokinet
; 41: 100408, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34710650
17.
Biodistribution studies for cell therapy products: Current status and issues.
Regen Ther
; 18: 202-216, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34307798
18.
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.
Nat Biotechnol
; 39(12): 1529-1536, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34385691
19.
Functional characteristics of the human ortholog of riboflavin transporter 2 and riboflavin-responsive expression of its rat ortholog in the small intestine indicate its involvement in riboflavin absorption.
J Nutr
; 140(10): 1722-7, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20724488
20.
Quantitative application of flow cytometry for the analysis of circulating human T cells: A preclinical pharmacokinetic study.
Drug Metab Pharmacokinet
; 35(2): 207-213, 2020 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-31980378