Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 9 de 9
Filtrar
1.
Biochem Biophys Res Commun ; 511(4): 935-940, 2019 04 16.
Artículo en Inglés | MEDLINE | ID: mdl-30853180

RESUMEN

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).. This article has been retracted at the request of < the Editor in Chief. The Editor in Chief has been made aware of numerous problems with this paper regarding authorship, poor or insufficient supervision of researchers and the unauthorized use of data acquired from a lab visit by one of the authors.


Asunto(s)
Regulación del Desarrollo de la Expresión Génica , Proteína de la Leucemia Promielocítica con Dedos de Zinc/genética , Linfocitos T/citología , Animales , Recuento de Células , Autorrenovación de las Células , Eliminación de Gen , Ratones , Ratones Endogámicos C57BL , Linfocitos T/metabolismo , Timocitos/citología , Timocitos/metabolismo , Timo/citología , Timo/crecimiento & desarrollo , Timo/metabolismo
3.
Shanghai Kou Qiang Yi Xue ; 28(1): 110-112, 2019 Feb.
Artículo en Zh | MEDLINE | ID: mdl-31081012

RESUMEN

Dentigerous cyst belongs to one kind of odontogenic cysts, and is also known as follicular cyst. After the formation of the crown or root of the tooth, liquid exudates between the residual enamel epithelium and the crown surface to form odontogenic cysts. Multiple odontogenic cysts are rare in the oral and maxillofacial regions, especially in different areas of the jaw. In this paper, we reported case with multiple odontogenic cysts and discussed its etiology,pathological classification,differential diagnosis and treatment.


Asunto(s)
Quiste Dentígero , Quistes Odontogénicos , Quiste Dentígero/diagnóstico , Quiste Dentígero/cirugía , Epitelio , Humanos , Mandíbula , Quistes Odontogénicos/diagnóstico , Quistes Odontogénicos/cirugía , Corona del Diente
4.
Front Microbiol ; 9: 1865, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30174659

RESUMEN

Hepatitis A virus (HAV) belongs to the family Picornaviridae. It is the pathogen of acute viral hepatitis caused by fecal-oral transmission. RNA viruses are sensed by pathogen-associated pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation-associated gene 5 (MDA5). PRR activation leads to production of type 1 interferon (IFN-α/ß), serving as the first line of defense against viruses. However, HAV has developed various strategies to compromise the innate immune system and promote viral propagation within the host cells. The long coevolution of HAV in hosts has prompted the development of effective immune antagonism strategies that actively fight against host antiviral responses. Proteases encoded by HAV can cleave the mitochondrial antiviral signaling protein (MAVS, also known as IPS-1, VISA, or Cardif), TIR domain- containing adaptor inducing IFN-ß (TRIF, also known as TICAM-1) and nuclear factor-κB (NF-κB) essential modulator (NEMO), which are key adaptor proteins in RIG-I-like receptor (RLR), TLR3 and NF-κB signaling, respectively. In this mini-review, we summarize all the recent progress on the interaction between HAV and the host, especially focusing on how HAV abrogates the antiviral effects of the innate immune system.

5.
J Parasitol ; 103(6): 692-698, 2017 12.
Artículo en Inglés | MEDLINE | ID: mdl-28953417

RESUMEN

It is important to isolate potential candidates from the local isolates of nematophagous fungi and to investigate interaction between the fungal strains and gastrointestinal nematodes for the biological control of parasitic nematodes in livestock. In the present study, we assessed the in vitro predatory activity and the viability of isolates of Arthrobotrys thaumasia ( Monacrosporium thaumasium) after passage through the gastrointestinal tract of sheep. The predatory process of a representative isolate selected against the larvae of trichostrongylids was prepared with a scanning electron microscope (SEM). In vitro experiments tested the ability of 9 native isolates of A. thaumasia to prey on larvae of feces of sheep infected with natural mixed nematodes ( Haemonchus contortus, Trichostongylus colubriformis, Marshallagia mongolica). These isolates of A. thaumasia decreased infectivity of third stage infective larvae (L3) by 75.54-99.97%; 7 isolates decreased infectivity by more than 90%. In vivo experiments also demonstrated significant reductions of L3 numbers in the feces treated with the 9 isolates after passing through the gastrointestinal tract of sheep, and these decreases ranged from 51.68 to 88.16%. The isolates tested were re-isolated in 5-g sub-samples of feces from sheep in each treatment group, indicating that these isolates had the capacity to prey upon larvae of trichostrongylids after the passage through gastrointestinal tract. SEM shows that at 6 hr after the larvae were added, including the second stage larvae (L2) and L3 of trichostrongylids, the isolate NBS 005 caught them; at 8 hr after being caught L2 was penetrated by the fungus while penetration of L3 occurred at 12 hr; at 78 hr post-capture L2 was completely destroyed by the fungus while complete digestion of L3 occurred at 84 hr.


Asunto(s)
Ascomicetos/fisiología , Trichostrongyloidea/microbiología , Análisis de Varianza , Animales , Ascomicetos/ultraestructura , Resistencia a Múltiples Medicamentos , Heces/parasitología , Tracto Gastrointestinal/microbiología , Tracto Gastrointestinal/parasitología , Larva/microbiología , Ganado , Masculino , Microscopía Electrónica de Rastreo , Control Biológico de Vectores , Distribución Aleatoria , Ovinos , Trichostrongyloidea/efectos de los fármacos , Trichostrongyloidea/ultraestructura
6.
Shanghai Kou Qiang Yi Xue ; 25(5): 638-640, 2016 Oct.
Artículo en Zh | MEDLINE | ID: mdl-28116444

RESUMEN

Multiple myeloma is the most common type of multifocal plasma cell proliferation in the bone marrow, whereas cases with multiple amyloidosis of oral cavity are rarely documented. Clinically, the disease is easily miss- diagnosed and mistreated due to lack of specificity. This article reported a rare case with multiple myeloma and amyloidosis of tongue, gingiva, buccal mucosa, followed by a review of relevant literature.


Asunto(s)
Amiloidosis/diagnóstico , Mieloma Múltiple/diagnóstico , Amiloidosis/terapia , Médula Ósea , Proliferación Celular , Encía , Humanos , Mucosa Bucal , Mieloma Múltiple/terapia , Lengua
7.
Shanghai Kou Qiang Yi Xue ; 24(5): 627-31, 2015 Oct.
Artículo en Zh | MEDLINE | ID: mdl-26598203

RESUMEN

PURPUSE: To investigate the distribution of non-thyroid and non-salivary gland neck lesions, in order to improve the diagnosis of cervical masses. METHODS: Eight hundred and seventeen patients with neck mass treated in our department between 2000 and 2013 were collected for retrospective analysis. RESULTS: There were 236 inflammatory masses, 276 congenital masses, 99 benign tumors, 80 primary malignant tumors and 126 metastatic malignant tumors, which accounted for 28.89%, 33.78%, 12.11%, 9.79% and 15.42%, respectively. The clinical characteristics were different among different lesions. CONCLUSIONS: Neck masses are in various forms. To understand the characteristics and patterns of onset, appropriate preoperative examination and multi-parameter comprehensive diagnosis is the key to improve diagnostic rate.


Asunto(s)
Neoplasias de Cabeza y Cuello/epidemiología , China/epidemiología , Neoplasias de Cabeza y Cuello/diagnóstico , Humanos , Cuello/anomalías , Estudios Retrospectivos
8.
Asian Pac J Cancer Prev ; 14(2): 781-4, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23621237

RESUMEN

AIM: The purpose of this study was to determine whether susceptibility to oral tongue squamous cell carcinoma (OSCC) is related to polymorphisms in the u-PA gene. METHODS: We examined the rs2227564 C/T and rs2227562 G/A single nucleotide polymorphisms (SNPs) in 196 OSCC patients and 201 age- and gender- matched controls via direct sequencing and PCR-RFLP methods. RESULTS: Significant differences were found in allelic and genotypic distributions of the rs2227564 and rs2227562 loci when comparing cases and controls. In addition, logistic analyses indicated that the rs2227564 C/T genotype was related to a 1.52-fold increased risk of developing OSCC (adjusted OR=1.521, 95%CI: 1.144~2.022, P=0.004). Linkage disequilibrium analysis was conducted and no association between the two loci was found (D'=0.031, r2=0.000). CONCLUSIONS: Our findings provide evidence that the rs2227564 C/T SNP in the u-PA gene is associated with the development of OSCC.


Asunto(s)
Carcinoma de Células Escamosas/genética , Neoplasias de la Lengua/genética , Activador de Plasminógeno de Tipo Uroquinasa/genética , Secuencia de Bases , China , Femenino , Frecuencia de los Genes , Predisposición Genética a la Enfermedad , Genotipo , Humanos , Desequilibrio de Ligamiento/genética , Masculino , Polimorfismo de Nucleótido Simple , Análisis de Secuencia de ADN
9.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 44(7): 425-9, 2009 Jul.
Artículo en Zh | MEDLINE | ID: mdl-19957577

RESUMEN

OBJECTIVE: To measure the bone mineral density (BMD) of mandible and investigate the relationship between mandible and the whole body skeleton BMD. METHODS: Healthy volunteers were recruited in north China, which were divided into 6 groups by age: > or = 20, > or = 30, > or = 40, > or = 50, > or = 60 and > or = 70 years older, 10 male and 10 female in each group. Dual-energy X-ray absoptiometery (DXA) was used to measure the BMD of the lumbar spine, the mentum of mandible and the mandibular angle. The results were analyzed statistically. RESULTS: The mineral density (MD) of the mentum was (1.310 9 +/- 0.035 5) g/cm2, the left mandibular angle (1.048 9 +/- 0.013 7) g/cm2, the right mandibular angle (1.0547 +/- 0.014 1) g/cm2, the lumbar spine (L2-L4) (1.121 1 +/- 0.017 2) g/cm2. There was a significant difference in mandibular angle and lumbar MD between men and women (P < 0.05). The MD of mandibular angle and lumbar spine decreased significantly after 50 years of age. CONCLUSIONS: The normal BMD of the mandibular mentum, mandibular angles and lumbar spine is obtained. The BMD of the mandibular angles is closely related to that of the lumbar spine. Mandible can be an appropriate measurement site in the evaluation of skeleton BMD status for the forecast of osteoporosis.


Asunto(s)
Densidad Ósea , Mandíbula/anatomía & histología , Adulto , Anciano , China , Femenino , Humanos , Masculino , Mandíbula/diagnóstico por imagen , Persona de Mediana Edad , Radiografía , Adulto Joven
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA