1.
J Org Chem
; 89(11): 7579-7590, 2024 Jun 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38781579
RESUMEN
A metal-free, mild, and efficient method for the synthesis of amides has been developed from the amination of aldehydes with hydroxylamines promoted by TBAF·3H2O in the presence of KOH. Control experiments showed that the nitrone was the intermediate of this amination. By this method, a series of amides, biologically active compounds bebenil and a COX inhibitor were obtained in moderate to good yields.