Pixel-Level Classification of Five Histologic Patterns of Lung Adenocarcinoma.

Lung adenocarcinoma is the most common histologic type of lung cancer. The pixel-level labeling of histologic patterns of lung adenocarcinoma can assist pathologists in determining tumor grading with more details than normal classification. We manually annotated a dataset containing a total of 1000 patches (200 patches for each pattern) of 512 × 512 pixels and 420 patches (contains test sets) of 1024 × 1024 pixels according to the morphological features of the five histologic patterns of lung adenocarcinoma (lepidic, acinar, papillary, micropapillary, and solid). To generate an even large amount of data patches, we developed a data stitching strategy as a data augmentation for classification in model training. Stitched patches improve the Dice similarity coefficient (DSC) scores by 24.06% on the whole-slide image (WSI) with the solid pattern. We propose a WSI analysis framework for lung adenocarcinoma pathology, intelligently labeling lung adenocarcinoma histologic patterns at the pixel level. Our framework contains five branches of deep neural networks for segmenting each histologic pattern. We test our framework with 200 unclassified patches. The DSC scores of our results outpace comparing networks (U-Net, LinkNet, and FPN) by up to 10.78%. We also perform results on four WSIs with an overall accuracy of 99.6%, demonstrating that our network framework exhibits better accuracy and robustness in most cases.

An Infusion Containers Detection Method Based on YOLOv4 with Enhanced Image Feature Fusion.

The detection of infusion containers is highly conducive to reducing the workload of medical staff. However, when applied in complex environments, the current detection solutions cannot satisfy the high demands for clinical requirements. In this paper, we address this problem by proposing a novel method for the detection of infusion containers that is based on the conventional method, You Only Look Once version 4 (YOLOv4). First, the coordinate attention module is added after the backbone to improve the perception of direction and location information by the network. Then, we build the cross stage partial-spatial pyramid pooling (CSP-SPP) module to replace the spatial pyramid pooling (SPP) module, which allows the input information features to be reused. In addition, the adaptively spatial feature fusion (ASFF) module is added after the original feature fusion module, path aggregation network (PANet), to facilitate the fusion of feature maps at different scales for more complete feature information. Finally, EIoU is used as a loss function to solve the anchor frame aspect ratio problem, and this improvement allows for more stable and accurate information of the anchor aspect when calculating losses. The experimental results demonstrate the advantages of our method in terms of recall, timeliness, and mean average precision (mAP).