RESUMEN
Oximes and hydroxylamines are a very important class of skeletons that not only widely exist in natural products and drug molecules, but also a class of synthon, which have been widely used in industrial production. Due to weak N-O σ bonds of oximes and hydroxylamines, they can be easily transformed into other functional groups by N-O bond cleavage. Therefore, the synthesis of N-heterocycle by using oximes and hydroxylamines as nitrogen sources has attracted wide attention. Recent advances for the synthesis of N-heterocycle through transition-metal-catalyzed and radical-mediated cyclization classified by the type of nitrogen sources and rings are summarized. In this paper, the recent advances in the N-O bond cleavage of oximes and hydroxylamines are reviewed. We hope that this review provides a new perspective on this field, and also provides a reference to develop environmentally friendly and sustainable methods.
Asunto(s)
Hidroxilaminas , Oximas , Oximas/química , Hidroxilaminas/química , Catálisis , Ciclización , NitrógenoRESUMEN
The title complex, [PdCl2(C8H14N2O)2]·2H2O, was obtained by N-O bond cleavage of the oxa-diazo-line rings of the trans-[di-chlorido-bis-(2,5,5-trimethyl-5,6,7,7a-tetra-hydro-pyrrolo-[1,2-b][1,2,4]oxa-diazole-N1)]palladium(II) complex. The palladium(II) atom exhibits an almost square-planar coordination provided by two trans-arranged chloride anions and a nitro-gen atom from each of the two neutral organic ligands. In the crystal, N-Hâ¯O, O-Hâ¯O and O-Hâ¯Cl hydrogen bonds link complex mol-ecules into double layers parallel to the bc plane.