1.
Bioorg Med Chem Lett
; 26(2): 251-256, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26684852
RESUMEN
The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail.