RESUMEN
BACKGROUND: Maternal folic acid intake has been associated with decreased risk for neurodevelopmental disorders including autism spectrum disorder (ASD). Genetic differences in folate metabolism could explain some inconsistencies. To our knowledge, newborn folate concentrations remain unexamined. METHODS: We measured folate in archived newborn dried blood spots of children from the CHARGE (Childhood Autism Risks from Genetics and the Environment) case-control study who were clinically confirmed at 24-60 months to have ASD (n = 380), developmental delay (n = 128), or typical development (n = 247). We quantified monthly folic acid intake from maternally-reported supplements and cereals consumed during pregnancy and 3 months prior. We assessed associations of newborn folate with maternal folic acid intake and with ASD or developmental delay using regression. We stratified estimates across maternal and child MTHFR genotypes. RESULTS: Among typically developing children, maternal folic acid intake in prepregnancy and each pregnancy month and prepregnancy prenatal vitamin intake were positively associated with newborn folate. Among children with ASD, prenatal vitamin intake in pregnancy months 2-9 was positively associated with newborn folate. Among children with developmental delay, maternal folic acid and prenatal vitamins during the first pregnancy month were positively associated with neonatal folate. Associations differed by MTHFR genotype. Overall, neonatal folate was not associated with ASD or developmental delay, though we observed associations with ASD in children with the MTHFR 677 TT genotype (odds ratio: 1.76, 95% CI = 1.19, 2.62; P for interaction = 0.08). CONCLUSION: Maternal prenatal folic acid intake was associated with neonatal folate at different times across neurodevelopmental groups. Neonatal folate was not associated with reduced ASD risk. MTHFR genotypes modulated these relationships.
Asunto(s)
Trastorno del Espectro Autista , Discapacidades del Desarrollo , Ácido Fólico , Metilenotetrahidrofolato Reductasa (NADPH2) , Autoinforme , Humanos , Ácido Fólico/sangre , Trastorno del Espectro Autista/epidemiología , Trastorno del Espectro Autista/sangre , Femenino , Estudios de Casos y Controles , Recién Nacido , Masculino , Embarazo , Discapacidades del Desarrollo/epidemiología , Discapacidades del Desarrollo/sangre , Metilenotetrahidrofolato Reductasa (NADPH2)/genética , Preescolar , Pruebas con Sangre Seca , Adulto , Suplementos Dietéticos , GenotipoRESUMEN
Objetivo: Correlacionar parámetros bioquímicos de hierro y desarrollo psicomotríz, en relación al origen social, en niños de 6 a 24 meses de Córdoba, Argentina. Material y Métodos: En 276 niños se determino el estado nutricional del hierro con el criterio de Hillman, combinando ferritina, hemoglobina y protoporfirina eritrocitaria, para desarrollo Escala de Bayley 11, y variables socioeconómicas. Resultados y Conclusiones: La anemia presento diferencias (p<0.05) entre los niveles soci21es, la depleción fue 42 % en la población total. El desarrollo motor fue homogéneo en los grupos sociales; mientras que el mental presento diferencias ( p< 0.05) en retraso leve y significativo, siendo los mas afectados los niños del nivel bajo. En desarrollo y parámetros bioquímicos, el 19 % de los niños con anemia y depleción, presentaron retraso motor leve, mientras que en desarrollo mental, el retraso leve y significativo afecto en doble proporción a los niños con depleción y anemia en comparación con los niños normales.
Aims: To correlate the iron biochemical screening with cognitive and motor development, related to social background, in 6 to 24 month infants. Methods: a population - based study of 276 children. The iron deficiency was determine by the modified criterion of Hillman ( 1996), combining three different screenings tests: serum ferritin, hemoglobin and erythrocyte protoporphyrin. To analyse development we used Bayley 11 Scale. Results and conclusions: the anaemia was significative different (p< 0,05) between social levels, 36% in children with low socioeconomic background, 8% for the high one and iron deficiency without anaemia 42% in the total population. The motor development was homogeneous by social groups, showed 1 % significative delay, 8% light delay. But the mental development shows significative differences (p<0,05) in both light and significative delay, been the must affected children with low socioeconomic background.