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1.
Clin Oral Implants Res ; 35(5): 573-584, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38467593

RESUMEN

OBJECTIVES: To introduce a modified guided bone regeneration (GBR) technique using intact periosteum and deproteinized bovine bone mineral (DBBM) for peri-implant augmentation and compare the clinical outcomes with those of conventional GBR. MATERIALS AND METHODS: Patients who received peri-implant augmentation in posterior sites between 2015 and 2021 were reviewed in this study. Group A was treated with a modified GBR technique, and Group B was treated with conventional GBR. For group comparison, propensity score matching was performed with a sensitivity analysis. The implant survival rate, dimensional changes in hard tissue, marginal bone loss (MBL), and peri-implant parameters were evaluated. RESULTS: In total, 114 implants from 98 patients were included. The implant survival rates were 95.74% in Group A and 95.00% in Group B during the follow-up period. At 6 months, the median horizontal thickness was recorded at 0.87 mm (IQ1-IQ3 = 0.00-1.75 mm) in Group A, exhibiting a relatively lower value compared to the corresponding measurement of 0.98 mm (IQ1-IQ3 = 0.00-1.89 mm) in Group B (p = .937). Vertical height displayed no statistically significant intergroup difference between the two groups (p = .758). The mean follow-up period was 25.83 ± 12.93 months after loading in Group A and 27.47 ± 21.29 months in Group B (p = .761). MBL and peri-implant parameters were comparable between the two groups. CONCLUSIONS: Within the limitations of this study, the modified GBR technique using intact periosteum and DBBM grafting might be a viable alternative to correct bone defects around implants in molar and premolar sites.


Asunto(s)
Regeneración Ósea , Regeneración Tisular Guiada Periodontal , Humanos , Estudios Retrospectivos , Femenino , Masculino , Persona de Mediana Edad , Estudios de Seguimiento , Adulto , Regeneración Tisular Guiada Periodontal/métodos , Implantación Dental Endoósea/métodos , Periostio/cirugía , Aumento de la Cresta Alveolar/métodos , Pérdida de Hueso Alveolar/cirugía , Resultado del Tratamiento , Anciano , Implantes Dentales
2.
J Craniofac Surg ; 35(4): 1174-1176, 2024 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-38635500

RESUMEN

STUDY DESIGN: Case report. Osteoradionecrosis (ORN) of the jaw is a potentially devastating consequence of head and neck irradiation. The progression of ORN can lead to loss of bone, teeth, soft tissue necrosis, pathologic fracture, and oro-cutaneous fistula. Reconstructive surgery has mostly been reserved for late-stage disease where segmental resections are frequently necessary. Evidence is emerging to support earlier treatment in the form of debridement in combination with soft tissue free flaps for intermediate-stage ORN. The authors present a case of a 76-year-old male with persistent Notani 2 ORN of the mandible, treated with surgical removal of all remaining mandibular teeth, transoral debridement of all necrotic mandibular bone, and bone coverage with a left medial femoral condyle (MFC) periosteal free flap based on the descending genicular artery. Treatment was uneventful both intraoperatively and postoperatively. Since surgery (15 mo) the patient has remained free from clinical and radiologic signs of ORN. The MFP periosteal free flap provided an excellent result with minimal surgical complexity and morbidity in this case. Such treatment at an intermediate stage likely results in a reduction in segmental resections, less donor site morbidity, less operative time, less overall treatment time, and possibly fewer postoperative complications compared with the status quo.


Asunto(s)
Desbridamiento , Colgajos Tisulares Libres , Osteorradionecrosis , Humanos , Masculino , Osteorradionecrosis/cirugía , Anciano , Fémur/cirugía , Enfermedades Mandibulares/cirugía , Periostio/cirugía , Procedimientos de Cirugía Plástica/métodos , Extracción Dental
3.
Clin Oral Investig ; 27(8): 4541-4552, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-37261496

RESUMEN

OBJECTIVES: Minipigs present advantages for studying oral bone regeneration; however, standardized critical size defects (CSD) for alveolar bone have not been validated yet. The objectives of this study are to develop a CSD in the mandibular alveolar bone in Aachen minipigs and to further investigate the specific role of periosteum. MATERIALS AND METHODS: Three female Aachen minipigs aged 17, 24, and 84 months were used. For each minipig, a split-mouth design was performed: an osteotomy (2 cm height × 2.5 cm length) was performed; the periosteum was preserved on the left side and removed on the right side. Macroscopic, cone beam computed tomography (CBCT), microcomputed tomography (µCT), and histological analyses were performed to evaluate the bone defects and bone healing. RESULTS: In both groups, spontaneous healing was insufficient to restore initial bone volume. The macroscopic pictures and the CBCT results showed a larger bone defect without periosteum. µCT results revealed that BMD, BV/TV, and Tb.Th were significantly lower without periosteum. The histological analyses showed (i) an increased osteoid apposition in the crestal area when periosteum was removed and (ii) an ossification process in the mandibular canal area in response to the surgical that seemed to increase when periosteum was removed. CONCLUSIONS: A robust model of CSD model was developed in the alveolar bone of minipigs that mimics human mandibular bone defects. This model allows to further investigate the bone healing process and potential factors impacting healing such as periosteum. CLINICAL RELEVANCE: This model may be relevant for testing different bone reconstruction strategies for preclinical investigations.


Asunto(s)
Regeneración Ósea , Periostio , Animales , Femenino , Porcinos , Humanos , Periostio/cirugía , Porcinos Enanos , Proyectos Piloto , Microtomografía por Rayos X , Regeneración Ósea/fisiología , Mandíbula/diagnóstico por imagen , Mandíbula/cirugía , Mandíbula/patología
4.
J Pediatr Orthop ; 43(3): e199-e203, 2023 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-36729607

RESUMEN

BACKGROUND: Once a child has developed chronic ankle instability with recurrent events despite conservative treatment, then ligamentous repair is warranted. We utilize a modification of the modified Broström-Gould technique that further incorporates the distal fibular periosteum into the construct. The purpose of this study was to describe the intermediate-term outcomes of our modified Broström-Gould technique for chronic lateral ankle instability in childhood athletes. METHODS: A retrospective review of children who underwent the surgical technique over a 10-year time period (2010 to 2019) was performed, excluding those with <2 years of follow-up. Demographic, surgical, and clinical data were recorded, as well as outcome scores: (1) the Marx activity scale, (2) University of California, Los Angeles activity score, and (3) foot and ankle outcomes score. Recurrent instability events, repeat surgeries, satisfaction with the surgical experience, and return to sport (if applicable) were also recorded. RESULTS: Forty-six children (43 females) with 1 bilateral ankle met the criteria with a mean age at surgery of 14.8 years, and a mean follow-up duration of 4.9 years. The mean Marx activity score was 9.0±5.1, the mean University of California, Los Angeles score was 8.3±1.8, and the mean total foot and ankle outcomes score was 84.0±15.6. Twenty-six ankles (55.3%) reported having at least 1 recurrent episode of instability and 6 of the ankles (12.8%) underwent revision surgery between 3.5 months and 6.5 years of the index procedure. Thirty-nine (84.8%) patients responded that they would undergo our surgery again. CONCLUSION: A modified Broström-Gould procedure can be performed in children with the incorporation of the adjacent periosteum, but recurrence of instability is distinctly possible with longer follow-up with a risk for revision surgery despite good subjective outcomes. LEVEL OF EVIDENCE: Level IV; retrospective case series.


Asunto(s)
Inestabilidad de la Articulación , Ligamentos Laterales del Tobillo , Femenino , Niño , Humanos , Adolescente , Tobillo , Estudios Retrospectivos , Periostio/cirugía , Articulación del Tobillo/cirugía , Ligamentos Laterales del Tobillo/cirugía , Inestabilidad de la Articulación/cirugía , Resultado del Tratamiento
5.
Bull Exp Biol Med ; 175(2): 286-290, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-37464195

RESUMEN

An experimental in vivo model has been developed on the rabbit mandible to study reparative regeneration of alveolar bone after intercortical split osteotomy and the role of the periosteum in the process of reparative osteogenesis. The peculiarity of this model is fixation of the periosteum over the reconstruction zone, which allows preserving the bone block displaced during surgery and leads to the formation of an organotypic structure of the regenerate with cortical and spongy bone.


Asunto(s)
Regeneración Ósea , Mandíbula , Animales , Conejos , Mandíbula/cirugía , Osteogénesis , Periostio/cirugía , Modelos Teóricos
6.
Ann Plast Surg ; 88(1s Suppl 1): S27-S32, 2022 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-35225845

RESUMEN

BACKGROUND: The concept of gingivoperiosteoplasty (GPP) in the mixed dentition stage as compared with secondary alveolar bone grafting (ABG) in management of alveolar cleft has not been much discussed upon. The authors present the experience with extensive GPP and ABG in the mixed dentition stage in complete bilateral alveolar cleft cases. METHODS: A retrospective review of nonsyndromic patients with complete bilateral alveolar cleft operated on with either GPP or ABG (iliac crest) in the mixed dentition stage with at least 1-year follow-up was performed. Dental occlusal radiographs were evaluated for level of bone gain using Bergland and Witherow scales. Statistical evaluation of clinical success and procedure-related complications was conducted using χ2 test and odds ratio. RESULTS: Twenty-four patients in the GPP group and 20 in the ABG group were comparatively studied. Clinical success rate as indicated by Bergland scales I and II (87.5% in GPP vs 82.5% in ABG; P = 0.731), complication rate (20.83% in GPP vs 30% in ABG; P = 0.484), and status of canine eruption showed no significant differences in clinical outcomes in both groups. CONCLUSIONS: The technique of extensive GPP as described by authors shows equal efficacy to secondary ABG for management of bilateral alveolar clefts during the mixed dentition period.


Asunto(s)
Injerto de Hueso Alveolar , Labio Leporino , Fisura del Paladar , Injerto de Hueso Alveolar/métodos , Trasplante Óseo , Labio Leporino/cirugía , Fisura del Paladar/cirugía , Dentición Mixta , Humanos , Periostio/cirugía , Estudios Retrospectivos
7.
Ann Plast Surg ; 89(2): 218-224, 2022 08 01.
Artículo en Inglés | MEDLINE | ID: mdl-35276708

RESUMEN

PURPOSE: Gradual elevation of periosteum from the bone surface is known to promote the adaptation of soft tissues and the formation of hard tissues. The aim of our study was to estimate the benefit of periosteal distraction osteogenesis (PDO) on de novo bone formation in a rat model. MATERIALS AND METHODS: After device placement, animals were allowed for a latency period of 7 days. Animals in the PDO group were subjected to distraction at a rate of 0.1 mm/d for 10 days. In the periosteal pumping (PP) group, the animals were subjected to distraction at a rate of 0.1 mm/d. The direction of distraction was alternated every 2 days. The animals were euthanized at 17, 31, and 45 days after surgery, and the samples were analyzed histologically and by microcomputed tomography. RESULTS: In both groups, the new bone was characterized as primary woven bone that was located at the leading edge of bone apposition. Bone volumes significantly increased throughout the observation period both in the PP group ( P = 0.018) and in the PDO group ( P < 0.001). The new bone was denser and more mature in the PP group than in the PDO group, and the difference was significant at the 31-day time point ( P = 0.024). However, the volume of the new bone was higher in the PDO at the 45-day time point ( P < 0.001). CONCLUSIONS: We propose that the PP may be applied to enhance the osteogenic capacity of periosteum without plate elevation. Because this is only a proof-of-principle study, the alternated protocol of periosteal distraction warrants evaluation in the future studies.


Asunto(s)
Osteogénesis por Distracción , Periostio , Animales , Estudios de Factibilidad , Osteogénesis , Osteogénesis por Distracción/métodos , Periostio/cirugía , Ratas , Cráneo/cirugía , Microtomografía por Rayos X
8.
Cleft Palate Craniofac J ; 59(8): 1017-1023, 2022 08.
Artículo en Inglés | MEDLINE | ID: mdl-34259074

RESUMEN

OBJECTIVE: To compare the prevalence of dental malformations and agenesis in patients who received or did not receive gingivoperiosteoplasty (GPP). DESIGN: Retrospective cohort study. PATIENTS: Review of patients born January 1, 2000, to December 31, 2007, with unilateral cleft lip and alveolus, with or without clefting of the secondary palate, who received GPP and/or secondary alveolar bone grafting (ABG). Patients were included if they had clinical images and dental radiographs available at ages 5 to 9 and 10 to 12 years. Ninety-four patients met the inclusion criteria; 46 treated with GPP, and 48 who did not receive GPP. OUTCOME MEASURES: Records were assessed for supernumerary, missing, and malformed teeth by a blinded examiner, and prevalence compared between groups using χ2 tests. RESULTS: Cleft side lateral incisors were absent in 54% of GPP patients, compared to 50% in the no-GPP group. Two patients in the GPP group and 1 in the no-GPP group had supernumerary lateral incisors. Most lateral incisors were undersized or peg shaped in both the no-GPP (83.3%) and GPP (71.4%) groups. In the GPP group, 5 (10.9%) patients exhibited central incisor agenesis, and 3 had significant hypoplasia. In the no-GPP group, 4 (8.3%) patients exhibited central incisor agenesis, and 5 (10.5%) significant hypoplasia. These differences were not statistically significant. CONCLUSIONS: Gingivoperiosteoplasty was not associated with increased prevalence of dental malformation or agenesis. When performed appropriately, GPP is a safe treatment technique that does not increase the risk of dental anomalies.


Asunto(s)
Labio Leporino , Fisura del Paladar , Labio Leporino/complicaciones , Labio Leporino/epidemiología , Labio Leporino/cirugía , Fisura del Paladar/complicaciones , Fisura del Paladar/epidemiología , Fisura del Paladar/cirugía , Humanos , Periostio/cirugía , Prevalencia , Estudios Retrospectivos
9.
BMC Oral Health ; 22(1): 439, 2022 10 08.
Artículo en Inglés | MEDLINE | ID: mdl-36209217

RESUMEN

BACKGROUND: Periodontal accelerated osteogenic orthodontics (PAOO) is a widely-used clinical procedure that combines selective alveolar corticotomy, particulate bone grafting, and the application of orthodontic forces. Different modifications of PAOO such as collagen-membrane coverage can better benefit patients from preventing displacement of grafts. Due to its stability, collagen-membrane coverage gradually gained popularity and became a widely-used procedure in traditional PAOO technique. OBJECTIVES: To quantitatively investigate the radiographic changes of alveolar bone, periodontal soft tissue changes of the mandibular anterior teeth and postoperative complications in periosteum-covered techniques compared with traditional surgical technique in PAOO. METHODS: Orthodontic camouflage for dental Class II or decompensation for skeletal Class III malocclusions were included; Patients with bone defects on the buccal aspects of the anterior mandible regions confirmed by clinical and radiographic examination were randomly divided into the periosteum coverage group or traditional technique group for PAOO. Cone-beam computerized tomography (CBCT) scans were obtained before treatment (T0) and 1 week (T1) and 12 months (T2) after operation. The primary outcome variable was the vertical alveolar bone level (VBL), the secondary evaluation parameters included labial horizontal bone thickness at the midpoint of the middle third (MHBT) or apical third (AHBT) to the limit of the labial cortical surface during a 12-month follow-up. Postoperative sequelae were evaluated after 2 days and 7 days in both the groups. Periodontal parameters were analyzed at T0 and T2. RESULTS: Thirty-six adult subjects were eligible and recruited in the present study. Although experimental group exhibited more severe infection, no significant differences of the postoperative symptoms or periodontal parameters was found between the 2 groups (P > 0.05). All patients were examined respectively using CBCT at baseline (T0), postoperative 1 week (T1) and 12 months (T2). Both alveolar bone height and width increased from T0 to T1 (P < 0.001) and then reduced from T1 to T2 (P < 0.001) in both groups. However, significant bone augmentation was achieved in each group from T0 to T2 (P < 0.001). Furthermore, the vertical alveolar bone augmentation in the experimental group increased significantly than that in the traditional surgery (P < 0.05). CONCLUSIONS: Compared with traditional PAOO surgery, the periosteum-covered technique provides superior graft stabilization and satisfactory vertical bone augmentation in the labial mandibular anterior area.


Asunto(s)
Maloclusión de Angle Clase III , Ortodoncia , Adulto , Colágeno/uso terapéutico , Tomografía Computarizada de Haz Cónico/métodos , Humanos , Maloclusión de Angle Clase III/cirugía , Periostio/diagnóstico por imagen , Periostio/cirugía
10.
BMC Musculoskelet Disord ; 21(1): 632, 2020 Sep 25.
Artículo en Inglés | MEDLINE | ID: mdl-32977786

RESUMEN

BACKGROUND: Management of Rüedi-Allgöwer III or AO/OTA type C3 pilon fracture presents numerous challenges to the orthopaedic surgeon. A joint preservation technique using a large autologous ilium with periosteum in combination with internal implant fixation was reported to improve the outcome of reconstruction. METHODS: Twenty-five patients according to Tscherne/Oestern FxCO-I closed fracture and FxOI open fractures classification after Rüedi-Allgöwer III or AO/OTA type C3 pilon fracture received a large autologous ilium with periosteum for tibiotalar joint reconstruction and open reduction and internal fixation (ORIF), between March 2015 and September 2018. The visual analog scale (VAS), American Orthopaedic Foot & Ankle Society (AOFAS) score, and Burwell and Charnley criteria were used for outcome analysis. RESULTS: Twenty patients with an average age of 45.2 years were followed for an average of 18.3 months. The VAS and AOFAS scores, and Burwell and Charnley ratings were recorded at the last follow-up after reconstructive surgery. Two patients developed redness and swelling at the wound site, but recovered after local care and dressing changes. No patient displayed deep surgical site infection, donor site complication, non-union or local complication during the final follow-up. The average bone union time was 18.3 months (range 3-36). CONCLUSIONS: Large autologous ilium with periosteum in combination with ORIF can be performed for tibiotalar joint reconstruction. This experimental procedure reduces the risk of post-operative complications following articular reconstruction for Rüedi-Allgöwer III or AO/OTA type C3 pilon fractures in short follow-up. LEVEL OF EVIDENCE: Level III, retrospective cohort study.


Asunto(s)
Ilion , Fracturas de la Tibia , Fijación Interna de Fracturas/efectos adversos , Humanos , Persona de Mediana Edad , Periostio/cirugía , Proyectos Piloto , Estudios Retrospectivos , Fracturas de la Tibia/diagnóstico por imagen , Fracturas de la Tibia/cirugía , Resultado del Tratamiento
11.
ScientificWorldJournal ; 2020: 8846285, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33293901

RESUMEN

BACKGROUND: Creating a secluded large space using guided bone regeneration (GBR) is a novel osteogenesis technique used in the prevention of premature membrane exposure complications. However, this technique is not considered clinically feasible. OBJECTIVES: This study aimed to compare the outcome of the insertion of two novel GBR devices in a rabbit calvarial model in terms of mode of action, simplicity, and amount of new space and bone gained. MATERIALS AND METHODS: The expansible GBR (EGBR) device, composed mainly of a titanium plate, silicone membrane, and activation screw, was inserted beneath the periosteum in the calvarial area of eight rabbits. The smart GBR (SGBR) device, composed of silicone sheets and Nitinol strips, were inserted beneath the periosteum in the calvarial area of another 10 rabbits. Half of each group was sacrificed 2 months after surgery, and the other half was sacrificed after 4 months. RESULTS: Histological and microradiographical analysis showed that, at 2 months, the EGBR device achieved a mean space gain of 207.2 mm3, a mean bone volume of 68.2 mm3, and a mean maximum bone height of 1.9 mm. Values for the same parameters at 4 months were 202.1 mm3, 70.3 mm3, and 1.6 mm, respectively. The SGBR device had significantly higher (P < 0.05) mean space gain (238.2 mm3; 239.5 mm3), bone volume (112.9 mm3, 107.7 mm3), and bone height (2.7 mm; 2.6 mm) than the EGBR device at 2 and 4 months, respectively. CONCLUSION: Both devices proved to be effective in augmenting bone vertically through the application of GBR and soft tissue expansion processes. However, the SGBR device was more efficient in terms of mode of action, simplicity, and amount of bone created in the new space.


Asunto(s)
Placas Óseas/normas , Regeneración Ósea/fisiología , Fijadores Internos/normas , Osteogénesis/fisiología , Cráneo/fisiología , Cráneo/cirugía , Animales , Tornillos Óseos/normas , Masculino , Periostio/fisiología , Periostio/cirugía , Conejos , Silicio/normas , Mallas Quirúrgicas/normas , Titanio/normas
12.
Surg Radiol Anat ; 42(1): 31-34, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31538246

RESUMEN

PURPOSE: Periosteal releasing incision (PRI) techniques are often used with guided bone regeneration procedures. As complications such as intra- and postoperative bleeding have been noticed, we aimed to study and clarify these as related to the PRI, especially on the mandibular buccal periosteum. METHODS: Fourteen sides from seven fresh-frozen Caucasian cadaveric heads were used in this study. The seven cadavers were derived from two females and five males. The mean age at the time of death was 75.9 ± 10.8 years. The PRI was made using a no. 15c blade using a surgical microscope. Subsequently, the fat tissue lateral to the periosteum was slightly dissected. The diameter of the facial artery (or its branch) and closest relationship between the tooth and position of the artery was recorded. Finally, the artery was traced back proximally to clarify its origin. RESULTS: On all sides, the inferior labial artery (ILA) was identified in the fat tissue lateral to and close to the periosteum. The ILA was closest to the periosteum at the midpoint of the PRI (approximately between the first and second molar teeth area or 10 mm mesial to the apex of the retromolar pad). The mean diameter of the ILA was 2.72 ± 0.26 mm. CONCLUSION: This anatomical finding should encourage dentists to make the PRI incision without invading the tissue underneath the periosteum.


Asunto(s)
Traumatismos de las Arterias Carótidas/etiología , Arteria Carótida Externa/anatomía & histología , Regeneración Tisular Guiada Periodontal/efectos adversos , Diente Molar/anatomía & histología , Periostio/anatomía & histología , Periostio/cirugía , Anciano , Anciano de 80 o más Años , Cadáver , Traumatismos de las Arterias Carótidas/prevención & control , Femenino , Regeneración Tisular Guiada Periodontal/métodos , Humanos , Masculino , Mandíbula/anatomía & histología , Diente Molar/cirugía , Colgajos Quirúrgicos
13.
Ann Chir Plast Esthet ; 65(1): 91-99, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31101396

RESUMEN

INTRODUCTION: Forehead osteoma is an uncommon benign bone tumor that causes cosmetic disfigurement and occasional pain. Traditional excision directly over the lesion creates a visible scar on the forehead. PROCEDURE: We describe a method of endoscopic resection of the forehead osteoma, via incisions within the hairline. The access incision was hidden behind the frontal hairline and the dissection plane went in the subperiosteal layer. The injury of the nerve branch and vessel can be easily avoided and endorsed by manipulating the endoscope. CONCLUSION: Aesthetic considerations are important features in the craniomaxillofacial region. Especially for patients who are not willing to accept the risk of a prominent forehead scar. Endoscopic resection of forehead osteomas might be a useful tool in forehead osteoma resections. It might be an alternative tool in an Oral and Maxillofacial Surgeon's and in a Plastic Surgeon's repertoire.


Asunto(s)
Cicatriz/prevención & control , Endoscopía/métodos , Neoplasias Faciales/cirugía , Frente/cirugía , Osteoma/cirugía , Complicaciones Posoperatorias/prevención & control , Neoplasias Craneales/cirugía , Disección/métodos , Humanos , Periostio/cirugía
14.
Oral Dis ; 25(2): 497-507, 2019 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-30325561

RESUMEN

PURPOSE: The management of maxillary medication-related osteonecrosis of the jaw (MRONJ) is challenging. Therefore, identifying the proper treatment is important. This study aimed to evaluate the surgical treatment of maxillary MRONJ using single-layer closure with mucoperiosteal flap and double-layer closure with buccal fat pad flap (BFPF) and mucoperiosteal flap and to find the outcomes after rehabilitation with obturators. METHODS: A retrospective analysis was conducted and included all surgically treated and followed-up maxillary MRONJ cases in a single center. Demographics and clinical data, stage of MRONJ, surgical treatment, and treatment outcome were collected. RESULTS: Seventy-nine lesions were included. Removal of necrotic bone was followed by coverage with mucoperiosteal flap in 60 lesions and BFPF in 14 lesions. Seven lesions (five primarily and two following unsuccessful treatment with BFPF) underwent necrectomy and were reconstructed with obturators. Complete mucosal healing was achieved in 76.7% of the lesions covered with mucoperiosteal flap. BFPF led to complete mucosal healing in 85.7% of the lesions. No complications were observed in the defects rehabilitated with obturators. CONCLUSION: Removal of necrotic bone followed by closure with mucoperiosteal flap is reliable for MRONJ treatment. BFPF is effective for closure of MRONJ-related oroantral communications (OACs).


Asunto(s)
Osteonecrosis de los Maxilares Asociada a Difosfonatos/cirugía , Enfermedades Maxilares/cirugía , Repitelización , Colgajos Quirúrgicos , Tejido Adiposo/cirugía , Anciano , Anciano de 80 o más Años , Conservadores de la Densidad Ósea/efectos adversos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Mucosa Bucal/cirugía , Periostio/cirugía , Estudios Retrospectivos
15.
Clin Orthop Relat Res ; 477(4): 741-755, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30810538

RESUMEN

BACKGROUND: Surgical reconstruction of large bone defects with structural bone allografts can restore bone stock but is associated with complications such as nonunion, fracture, and infection. Vascularized reconstructive techniques may provide an alternative in the repair of critical bone defects; however, no studies specifically addressing the role of vascularized periosteal flaps in stimulating bone allograft revascularization and osseointegration have been reported. QUESTIONS/PURPOSES: (1) Does a vascularized periosteal flap increase the likelihood of union at the allograft-host junction in a critical-size defect femoral model in rats? (2) Does a vascularized periosteal flap promote revascularization of a critical-size defect structural bone allograft in a rat model? (3) What type of ossification occurs in connection with a vascularized periosteal flap? METHODS: Sixty-four rats were assigned to two equal groups. In both the control and experimental groups, a 5-cm critical size femoral defect was created in the left femur and then reconstructed with a cryopreserved structural bone allograft and intramedullary nail. In the experimental group, a vascularized periosteal flap from the medial femoral condyle, with a pedicle based on the descending genicular vessels, was associated with the allograft. The 32 rats of each group were divided into subgroups of 4-week (eight rats), 6-week (eight rats), and 10-week (16 rats) followup. At the end of their assigned followup periods, the animals were euthanized and their femurs were harvested for semiquantitative and quantitative analysis using micro-CT (all followup groups), quantitative biomechanical evaluation (eight rats from each 10-week followup group), qualitative confocal microscopic, backscattered electron microscopic, and histology analysis (4-week and 6-week groups and eight rats from each 10-week followup group). When making their analyses, all the examiners were blinded to the treatment groups from which the samples came. RESULTS: There was an improvement in allograft-host bone union in the 10-week experimental group (odds ratio [OR], 19.29 [3.63-184.50], p < 0.05). In contrast to control specimens, greater bone neoformation in the allograft segment was observed in the experimental group (OR [4-week] 63.3 [39.6-87.0], p < 0.05; OR [6-week] 43.4 [20.5-66.3], p < 0.05; OR [10-week] 62.9 [40.1-85.7], p < 0.05). In our biomechanical testing, control samples were not evaluable as a result of premature breakage during the embedding and assembly processes. Therefore, experimental samples were compared with untreated contralateral femurs. No difference in torsion resistance pattern was observed between both groups. Both backscattered electron microscopy and histology showed newly formed bone tissue and osteoclast lacunae, indicating a regulated process of bone regeneration of the initial allograft in evaluated samples from the experimental group. They also showed intramembranous ossification produced by the vascularized periosteal flap in evaluated samples from the experimental group, whereas samples from the control group showed an attempted endochondral ossification in the allograft-host bone junctions. CONCLUSIONS: A vascularized periosteal flap promotes and accelerates allograft-host bone union and revascularization of cryopreserved structural bone allografts through intramembranous ossification in a preclinical rat model. CLINICAL RELEVANCE: If large-animal models substantiate the findings made here, this approach might be used in allograft reconstructions for critical defects using fibular or tibial periosteal flaps as previously described.


Asunto(s)
Trasplante Óseo/métodos , Fracturas del Fémur/cirugía , Fémur/irrigación sanguínea , Fémur/cirugía , Neovascularización Fisiológica , Oseointegración , Periostio/irrigación sanguínea , Periostio/cirugía , Colgajos Quirúrgicos/irrigación sanguínea , Aloinjertos , Animales , Modelos Animales de Enfermedad , Fracturas del Fémur/diagnóstico por imagen , Fracturas del Fémur/fisiopatología , Fémur/diagnóstico por imagen , Fémur/fisiopatología , Curación de Fractura , Masculino , Ratas Sprague-Dawley , Factores de Tiempo
16.
Clin Oral Investig ; 23(1): 351-359, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29680992

RESUMEN

OBJECTIVES: Actually, there is no detailed guidance on how to deal with wound closure after surgical removal of medication-related osteonecrosis of the jaw (MRONJ) lesions. This study attempts to compare the difference in outcome between the mucosal and the mucoperiosteal flap closure after surgery. PATIENTS AND METHODS: In this retrospective monocentric cohort study, patients (n = 61; 35 female/26 male) suffering from MRONJ and requiring surgical therapy at the University of Aachen between 2013 and 2015 were included. Due to intra-institutional variances, one group was treated with the mucosal, the other group with the mucoperiosteal technique. The success rate, i.e., mucosal closure and no relapse at the point of follow-up, was evaluated and compared. All patients were clinically investigated for the postoperative follow-up during a special consultation appointment. RESULTS: The success rates between the different techniques after 2 years follow-up were very similar. In the group of mucosal wound closure, 22 of 29 (75.86%) patients revealed mucosal integrity without signs of MRONJ. The rate in the mucoperiosteal wound closure group was almost identical (24 of 32 (75%)). CONCLUSION: No differences in the success rates between the two different techniques could be evaluated. CLINICAL RELEVANCE: The results of this study suggest that the complete removal of the necrotic bone might have a higher impact on the success rates than the technique of the wound closure. Due to the fact that the mucoperiosteal wound closure technique offers a better overview of the extent of the MRONJ lesion, the authors advise to use this technique.


Asunto(s)
Osteonecrosis de los Maxilares Asociada a Difosfonatos/cirugía , Mucosa Bucal/cirugía , Periostio/cirugía , Técnicas de Cierre de Heridas , Cicatrización de Heridas/fisiología , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento
17.
J Craniofac Surg ; 30(3): e231-e233, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30730515

RESUMEN

OBJECTIVE: To present and assess a new, simple, conservative modification of hyoidthyroidpexy using 2 sutures between hyoid periosteum and thyroid lamina. METHODS: Included patients had obstructive sleep apnea with apnea hypopnea index >20. Through a small midline neck incision, 2 Vicryl sutures were applied between the hyoid periosteum and thyroid cartilage. Infrahyoid and suprahyoid muscles were not traumatized. RESULTS: In 19 patients, the mean apnea hypopnea index significantly dropped (P < 0.0001) from 51.5 ±â€Š11.9 preoperatively to 10.1 ±â€Š4.9 postoperatively. The mean lowest oxygen saturation significantly increased from 79.2 ±â€Š10.2 to 89.5 ±â€Š8.1 (P = 0.0015). Moreover, Epworth sleepiness scale showed significant improvements (P < 0.0001) as its mean diminished from 13.8 ±â€Š2.9 to 5.3 ±â€Š2.9. CONCLUSION: The hyoid periosteum sutures technique (simple modification of hyoidthyroidpexy) is considered effective easily applicable, less costly with limited tissue dissection. It could be combined with other procedures in multilevel surgery for obstructive sleep apnea.


Asunto(s)
Hueso Hioides/cirugía , Tratamientos Conservadores del Órgano/métodos , Periostio/cirugía , Apnea Obstructiva del Sueño/cirugía , Técnicas de Sutura , Glándula Tiroides/cirugía , Humanos , Suturas
18.
J Craniofac Surg ; 30(1): e76-e77, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30480636

RESUMEN

The nasal lining by suturing a vomer flap onto the bony ridge of the cleft through a hole was repaired.A 16-month-old girl had an incomplete bilateral posterior cleft palate. While incising the periosteum and elevating the nasal mucosa from the cleft edge of the right side, the mucosa was sheared and a buttonhole was made, and as a result, the nasal lining could not be coapted. A vomer flap to close the nasal lining was applied. On the left side, the nasal mucosa from the cleft margin was sutured to the vomer flap. On the right side, where no nasal lining was available, 2 holes were drilled 5 mm lateral to each bony cleft margin, and the vomer flap was sutured to the palate with 4-0 vicryl through the holes. The elevated bilateral mucoperiosteal flaps were brought together to the midline and sutured to the anterior triangular flap in a V-Y pushback fashion.This method could be used to cover the nasal lining when nasal mucosa is not available.


Asunto(s)
Fisura del Paladar/cirugía , Paladar Duro/cirugía , Procedimientos de Cirugía Plástica/métodos , Colgajos Quirúrgicos , Técnicas de Sutura , Vómer/cirugía , Femenino , Humanos , Lactante , Mucosa Nasal/cirugía , Periostio/cirugía , Suturas
19.
J Orthop Sci ; 24(2): 342-346, 2019 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-30389310

RESUMEN

BACKGROUND: Osteofibrous dysplasia usually progresses until ten years of age and occasionally regresses spontaneously after puberty. Patients with osteofibrous dysplasia usually require close observation. Surgery is an option considered only for extensive, deforming lesions and those with pathological fractures and rapid progression prior to puberty. If surgery is indicated, the traditional intra-lesional curettage or subperiosteal resection usually leads to high recurrence. Hence, extraperiosteal wide excision and various methods of reconstruction after resection have been advocated for this lesion. We reviewed the clinical results of patients managed with extraperiosteal segmental excision and reconstruction by liquid nitrogen-treated tumor-bearing autograft combined with allograft. METHODS: From January 2010 to December 2014, twelve patients with final diagnosis of tibial osteofibrous dysplasia were studied retrospectively. All these patients were treated with extraperiosteal segmental excision and reconstruction by liquid nitrogen-treated tumor-bearing autograft combined with allograft. RESULTS: The patient group consisted of 5 males and 7 females, with a median age of 13 years (6-24 years). 3 lesions were located in left tibia and 9 in right. The median length of resected segment was 8 cm (5-11 cm). The patients were followed for 36-84 months (median 52 months). Follow-up radiographs showed that the median time for complete union of the grafted bone was 9 months (6-15 months). There was no evidence of recurrence. All patients had full range of motion in the knee and ankle joints after surgery. CONCLUSIONS: Extraperiosteal segmental excision for osteofibrous dysplasia of tibia with reconstruction by liquid nitrogen-treated recycled autograft and allograft is a good surgical option to prevent recurrence and fill bone defects in this rare lesion.


Asunto(s)
Enfermedades del Desarrollo Óseo/cirugía , Neoplasias Óseas/cirugía , Osteotomía/métodos , Procedimientos de Cirugía Plástica/métodos , Tibia/cirugía , Adolescente , Aloinjertos , Autoinjertos , Enfermedades del Desarrollo Óseo/diagnóstico por imagen , Enfermedades del Desarrollo Óseo/patología , Neoplasias Óseas/diagnóstico por imagen , Neoplasias Óseas/patología , Placas Óseas , Niño , Estudios de Cohortes , Terapia Combinada , Legrado/métodos , Femenino , Humanos , Masculino , Nitrógeno/farmacología , Osteotomía/instrumentación , Periostio/cirugía , Cuidados Posoperatorios/métodos , Pronóstico , Estudios Retrospectivos , Factores de Riesgo , Tibia/patología , Resultado del Tratamiento , Cicatrización de Heridas/fisiología , Adulto Joven
20.
J Foot Ankle Surg ; 58(4): 674-678, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30962108

RESUMEN

Long-term results of anatomic reconstruction for chronic ankle instability are good, but no study has shown the results of fibular periosteum ligamentoplasty associated with extensor retinaculum flap at long-term follow-up. To demonstrate the efficacy of fibular periosteum ligamentoplasty and extensor retinaculum flap in chronic lateral instability, 40 patients underwent surgery for ankle instability. Thirty-three (82.5%) patients were reviewed, with a median follow-up duration of 8.2 (range 4 to 13) years. Functional results were assessed using the Karlsson score. Static and dynamic x-ray images were realized to measure varus tilt and anterior drawer, and osteoarthritis was evaluated with the van Dijk classification. The median Karlsson score was 95 (range 80 to 100). The mean decrease in varus laxity was 11° (range 0 to 18) and in anterior drawer was 1 (range -8 to 4) mm. At the last follow-up visit, 3 (7.5%) patients showed an evidence of osteoarthritis according to the preoperative criteria of the van Dijk classification (grade 2) and 6 (15%) patients had radiologic changes, without narrowing of the joint space (grade 1). Studies that have a follow-up time >5 years are rare. This study shows that despite the excellent control of ankle laxity, severe radiographic changes (grade 2) continue to evolve in the long term. This study indicates a good long-term outcome but suggests the need to monitor the occurrence of osteoarthritis over the long term.


Asunto(s)
Articulación del Tobillo/cirugía , Inestabilidad de la Articulación/cirugía , Ligamentos Articulares/cirugía , Procedimientos de Cirugía Plástica/métodos , Colgajos Quirúrgicos , Adulto , Traumatismos del Tobillo/complicaciones , Articulación del Tobillo/diagnóstico por imagen , Atletas , Femenino , Estudios de Seguimiento , Humanos , Inestabilidad de la Articulación/etiología , Masculino , Satisfacción del Paciente , Periostio/cirugía , Complicaciones Posoperatorias/diagnóstico por imagen , Radiografía , Estudios Retrospectivos
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