Big Data in sleep apnoea: Opportunities and challenges.

Sleep apnoea is now regarded as a highly prevalent systemic, multimorbid, chronic disease requiring a combination of long-term home-based treatments. Optimization of personalized treatment strategies requires accurate patient phenotyping. Data to describe the broad variety of phenotypes can come from electronic health records, health insurance claims, socio-economic administrative databases, environmental monitoring, social media, etc. Connected devices in and outside homes collect vast amount of data amassed in databases. All this contributes to 'Big Data' that, if used appropriately, has great potential for the benefit of health, well-being and therapeutics. Sleep apnoea is particularly well placed with regards to Big Data because the primary treatment is positive airway pressure (PAP). PAP devices, used every night over long periods by millions of patients across the world, generate an enormous amount of data. In this review, we discuss how different types of Big Data have, and could be, used to improve our understanding of sleep-disordered breathing, to identify undiagnosed sleep apnoea, to personalize treatment and to adapt health policies and better allocate resources. We discuss some of the challenges of Big Data including the need for appropriate data management, compilation and analysis techniques employing innovative statistical approaches alongside machine learning/artificial intelligence; closer collaboration between data scientists and physicians; and respect of the ethical and regulatory constraints of collecting and using Big Data. Lastly, we consider how Big Data can be used to overcome the limitations of randomized clinical trials and advance real-life evidence-based medicine for sleep apnoea.

An interprofessional approach to managing children with treatment-resistant enuresis: an educational review.

Enuresis (intermittent urinary incontinence during sleep in a child aged ≥ 5 years) is commonly seen in paediatric practice. Despite the availability of effective interventions, treatment resistance is encountered in up to 50% of children. In this educational review we attempt to provide insight into the causes of treatment resistance, and offer practical suggestions for addressing this condition using an interprofessional approach. We explore the pathophysiology of and standard treatments for enuresis and discuss why standard treatments may fail. An interprofessional approach to treatment resistance is proposed which utilises the expertise of professionals from different disciplines to address the problems and barriers to treatment. The two interprofessional approaches include a multidisciplinary approach that involves the patient being sent to experts in different disciplines at different times to address their treatment resistance utilising the skills of the respective experts, and an interdisciplinary approach that involves a patient being managed by members of interdisciplinary team who integrate their separate discipline perspectives into a single treatment plan. Although an interdisciplinary approach is ideal, interdisciplinary teams may not be available in all circumstances. Understanding the roles of other disciplines and engaging clinicians from other disciplines when appropriate can still be helpful when treatment resistance is encountered.

Treatment options for disorders of arousal: a case series.

BACKGROUND: Non-rapid-eye-movement parasomnias or disorders of arousal (DOA) are more prevalent in children, but they do occur in adults. There are no practice parameters published for treatment of DOAs. METHODS: After obtaining institutional review board approval, an electronic search was conducted for ICD9 codes related to DOAs in our clinic databases. The resulting charts were reviewed by the authors for accuracy, and 103 out of 232 were included in the final analysis. RESULTS: Sleepwalking is the most common DOA presentation. Treatment with low-dose clonazepam has a response rate of 73.7%. Cognitive behavioral therapy (CBT) for insomnia, sertraline, clomipramine and temazepam may also be effective alternatives. CONCLUSION: DOAs respond to benzodiazepines, antidepressants and CBT. Large, randomized trials are needed to further assess these therapeutic alternatives.

Update on nonpharmacological interventions in parasomnias.

Parasomnias are abnormal behaviors that occur during sleep and can be associated, in particular during adulthood, with impaired sleep quality, daytime dysfunction, and occasionally with violent and harmful nocturnal behaviors. In these cases, therapies are often considered. Longterm pharmacological treatments are not always well tolerated and often have limited efficacy. Therefore, behavioral approaches remain an important treatment option for several types of parasomnias. However, the evidence-based approaches are limited. In the current review, we highlight results from various nonpharmacological techniques on different types of parasomnias and provide a glimpse into the future of nonpharmacological treatments in this field.

Kids that go bump in the night.

BACKGROUND: Incomplete arousal from deep sleep in children causes night time disruption and can present as confusional arousals, sleep walking or night terrors. These nocturnal events are common in childhood but can be extremely concerning to parents and disruptive to families. OBJECTIVE: This article provides a framework for the initial assessment of children's nocturnal events. DISCUSSION: Occasionally night time disturbances are seizures. A framework discussing the clinical features of typical benign childhood events and how to differentiate them from seizure disorders is presented. Generally, sleep walking and night terrors are self limiting and children grow out of them. However, in some cases there are ongoing precipitants that are important to identify and treat.

Treating insomnia improves depression, maladaptive thinking, and hyperarousal in postmenopausal women: comparing cognitive-behavioral therapy for insomnia (CBTI), sleep restriction therapy, and sleep hygiene education.

INTRODUCTION: Depression increases during menopause, and subclinical depressive symptoms increase risk for major depression. Insomnia is common among postmenopausal women and increases depression-risk in this already-vulnerable population. Recent evidence supports the efficacy of cognitive-behavioral therapy for insomnia (CBTI) to treat menopausal insomnia, but it remains unclear whether treating insomnia also alleviates co-occurring depressive symptoms and depressogenic features. This trial tested whether CBTI improves depressive symptoms, maladaptive thinking, and somatic hyperarousal in postmenopausal women with insomnia; as well as whether sleep restriction therapy (SRT)-a single component of CBTI-is equally efficacious. MATERIALS AND METHODS: Single-site, randomized controlled trial. 117 postmenopausal women (56.34 ± 5.41 years) with peri-or-postmenopausal onset of chronic insomnia were randomized to three treatment conditions: sleep hygiene education control (SHE), SRT, and CBTI. Blinded assessments were performed at baseline, posttreatment, and six-month follow-up. RESULTS: CBTI produced moderate-to-large reductions in depressive symptoms, whereas SRT produced moderate reductions but not until six months posttreatment. Treatment effects on maladaptive thinking were mixed. CBTI and SRT both produced large improvements in dysfunctional beliefs about sleep, but weaker influences on presleep cognitive arousal, rumination, and worry. Presleep somatic arousal greatly improved in the CBTI group and moderately improved in the SRT group. Improvements in depression, maladaptive thinking, and hyperarousal were linked to improved sleep. SHE produced no durable treatment effects. CONCLUSIONS: CBTI and SRT reduce depressive symptoms, dysfunctional beliefs about sleep, and presleep somatic hyperarousal in postmenopausal women, with CBTI producing superior results. Despite its cognitive emphasis, cognitive arousal did not respond strongly or durably to CBTI. NAME: Behavioral Treatment of Menopausal Insomnia: Sleep and Daytime Outcomes. URL: clinicaltrials.gov. REGISTRATION: NCT01933295.

Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea.

ABSTRACT: Sleep-related abnormal sexual behaviors (sexsomnia) are classified as a subtype of NREM sleep parasomnias. Sexsomnia has been reported as part of parasomnia overlap disorder (POD) in two other patients. We present the case of a 42-year-old male patient with video-polysomnography (vPSG) documented POD. The patient had sleepwalking, sleep-related eating, confusional arousals, sexsomnia, sleeptalking, and REM sleep behavior disorder (RBD). Confusional arousals and RBD were documented during the vPSG. This case had the added complexity of obstructive sleep apnea (OSA) playing a role in sleepwalking and sleep related eating, with good response to nasal continuous positive airway pressure (nCPAP). The sexsomnia did not respond to nCPAP but responded substantially to bedtime clonazepam therapy.

Arousal disorders.

Arousal Disorders (AD) are motor behaviours arising from NREM sleep. They comprise a spectrum of manifestations of increasing complexity from confusional arousal to sleep terror to sleepwalking. AD usually appear in childhood with a low frequency of episodes and spontaneously disappear before adolescence. The advent of video-polysomnography disclosed the existence of other phenomena alongside AD, in particular nocturnal frontal lobe seizures, requiring a differential diagnosis from AD. History-taking is usually sufficient to establish a correct diagnosis of AD even though viewing the episodes is essential for the clinician to distinguish the different motor events. Videopolysomnographic recording in a sleep laboratory is not always necessary and homemade video-recordings are useful to capture events closest to real life episodes.

Dramatic parasomnias: recognition and treatment.

As each of the many parasomnias requires its own specific treatment, confusion between them can have serious consequences. By recognizing their distinctive features, misdiagnosis can be avoided and the appropriate management decided.

[Diagnostic criteria and treatment for sleep-disordered breathing: RERA]. / Critérios diagnósticos e tratamento dos distúrbios respiratórios do sono: RERA.

In polysomnography, RERA is defined as a respiratory parameter that indicates an arousal associated with a respiratory event and an increase in respiratory effort. Initially, RERA was described by means of esophageal manometry for the evaluation of respiratory effort. This greater respiratory effort occurs as a response to an increase in upper airway resistance, which is a factor present in the pathophysiology of sleep-disordered breathing, such as obstructive sleep apnea syndrome and upper airway resistance syndrome. Later, the use of a nasal pressure cannula was reported to be a reliable means of identifying airflow limitation and one that is more sensitive than is a thermistor. In addition, the nasal pressure cannula method has been used as a surrogate for esophageal manometry in the identification of periods in which upper airway resistance increases. Consequently, the American Academy of Sleep Medicine recommend the use of either method for the identification of RERA, which is defined by the flattening of the inspiratory curve, characteristic of airflow limitation. Although RERA has been identified and evaluated in current medical practice, it has yet to be standardized. Therefore, it is recommended that polysomnographic reports indicate which abnormal respiratory events were taken into consideration in the evaluation of the severity of sleep-disordered breathing.

Parasomnias and movement disorders in children and adolescents.

Childhood parasomnias and movement disorders arise from a variety of etiologic factors. For some children, psychopathology plays a causal role in sleep disorders; in other cases, recurrent parasomnia episodes induce psychopathology. Current research reveals complex interconnections between sleep and mental health. As such, it is important that clinicians consider the impact psychiatric disorders have on childhood parasomnias. This article describes common parasomnias and movement disorders in children and adolescents, with emphasis on psychologic and behavioral comorbidities.

Critérios diagnósticos e tratamento dos distúrbios respiratórios do sono: RERA / Diagnostic criteria and treatment for sleep-disordered breathing: RERA

Na polissonografia, RERA é definido como um parâmetro respiratório que indica um despertar associado a um evento respiratório e um aumento do esforço respiratório. Inicialmente, RERA foi descrito com o uso da manometria esofágica utilizada para avaliação do esforço respiratório. Esse maior esforço respiratório ocorre como resposta a um aumento da resistência da via aérea superior, aspecto presente na fisiopatologia dos distúrbios respiratórios do sono, entre esses, SAOS e SRVAS. Posteriormente, o uso de cânula de pressão nasal foi relatado como uma maneira confiável e mais sensível que o termistor para a identificação de eventos de redução do fluxo aéreo e também como um substituto da manometria esofágica para a identificação de períodos de aumento da resistência na via aérea superior. Consequentemente, a American Academy of Sleep Medicine recomenda o uso de um dos métodos para a identificação de RERA, que é definido por um padrão de achatamento da curva inspiratória, característico da limitação ao fluxo aéreo. Embora RERA seja identificado e avaliado na pratica médica, sua padronização ainda é necessária. Portanto, recomenda-se que os laudos de polissonografia indiquem quais eventos respiratórios anormais foram considerados na avaliação do grau de gravidade do distúrbio respiratório.

In polysomnography, RERA is defined as a respiratory parameter that indicates an arousal associated with a respiratory event and an increase in respiratory effort. Initially, RERA was described by means of esophageal manometry for the evaluation of respiratory effort. This greater respiratory effort occurs as a response to an increase in upper airway resistance, which is a factor present in the pathophysiology of sleep-disordered breathing, such as obstructive sleep apnea syndrome and upper airway resistance syndrome. Later, the use of a nasal pressure cannula was reported to be a reliable means of identifying airflow limitation and one that is more sensitive than is a thermistor. In addition, the nasal pressure cannula method has been used as a surrogate for esophageal manometry in the identification of periods in which upper airway resistance increases. Consequently, the American Academy of Sleep Medicine recommend the use of either method for the identification of RERA, which is defined by the flattening of the inspiratory curve, characteristic of airflow limitation. Although RERA has been identified and evaluated in current medical practice, it has yet to be standardized. Therefore, it is recommended that polysomnographic reports indicate which abnormal respiratory events were taken into consideration in the evaluation of the severity of sleep-disordered breathing.