RESUMEN
1. Beta dimethylaminoethyl benzhydryl ether hydrochloride (Benadryl) is a member of a new group of pharmacologically active antihistamine drugs. 2. Its use in amounts of 50 to 100 mg. given orally one to five times daily to a diverse group of 18 patients with both acute and chronic urticaria is reported. 3. Eleven patients experienced prompt relief of symptoms as long as the drug was taken. Three had definite and real improvement, and many of the wheals which did appear were not pruritic. Four patients were not benefited. 4. The drug has a wide margin of safety, and the only toxic manifestations noted were drowsiness and muscular aching (2 cases) and dizziness, weakness and vertigo (1 case). No cumulative toxic symptoms were noted in patients who ingested the drug as long as six or seven months. All toxic symptoms promptly disappeared when the drug was discontinued. 5. The effect is palliative, and in many patients the urticaria recurred when the administration of the drug was discontinued. 6. Since an antihistamine drug seems to be effective in controlling urticaria, it may be assumed that this is further indirect evidence that histamine is a factor in the production of urticaria.
Asunto(s)
Dermatología/historia , Difenhidramina/historia , Urticaria/historia , Adolescente , Adulto , Anciano , Difenhidramina/uso terapéutico , Femenino , Historia del Siglo XX , Humanos , Masculino , Persona de Mediana Edad , Urticaria/tratamiento farmacológicoRESUMEN
Urticaria and angioedema are ancient diseases. Many different names have been used to describe them, and many different theories have been postulated to explain their origin and pathogenesis. The current classification and nomenclature of urticaria and angioedema have evolved over several millennia, with many detours and problems, some of which still remain to be solved. This chapter describes the history of urticaria and angioedema. The evolution of selected aspects of today's understanding of both conditions is also traced, based on the review of original sources and previously published research on this topic.
Asunto(s)
Angioedema/etiología , Urticaria/etiología , Angioedema/historia , Animales , Hipersensibilidad a los Alimentos/etiología , Historia del Siglo XVI , Historia del Siglo XVIII , Historia del Siglo XIX , Historia Antigua , Humanos , Medicina Tradicional China , Urticaria/historiaAsunto(s)
Dermatología/historia , Prurigo/historia , Urticaria/historia , Francia , Historia del Siglo XX , HumanosRESUMEN
La urticaria crónica (VC), es una variante común de la urticaria que se define como un síndrome reactivo de la piel y mucosas caracterizado por la presencia de placas eritematosas, habones o ronchas edematosas y pruriginosas que se prolonga durante más de seis semanas. La etiología de la VC no es muy clara en la mayoría de los casos, multitud de causas se han implicado. La patogenia es compleja. El conocimiento y estudio de cada uno de los factores celulares y solubles, su interacción dinámica, vías efectoras y trama de citoquinas conducirá al logro de una terapéutica efectiva y racional de la urticaria crónica.
Chronic urticaria (VC) is a common variant of urticaria which is defined as a reactive skin and mucous membranes syndrome characterized by the presence of plaques erythematous, wheals, or swollen and itchy hives that lasts more than six weeks. The etiology of the VC is not very clear in the majority of cases, multitude of causes have been implicated. The pathogenesis is complex. Knowledge and study of each cell and soluble factors, their dynamic interaction, effector pathways and cytokines plot will lead to the achievement of an effective and rational therapy of chronic urticaria.