Detalhe da pesquisa
1.
Radiation in Combination with Immune Checkpoint Blockade and DNA Damage Response Inhibitors in Mice: Dosage Optimization in MC38 Syngeneic Tumors via Modelling and Simulation.
J Pharmacol Exp Ther
; 387(1): 44-54, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37348964
2.
Evaluation of area under the concentration curve adjusted by the terminal-phase as a metric to reduce the impact of variability in bioequivalence testing.
Br J Clin Pharmacol
; 88(2): 619-627, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272747
3.
Dose individualisation in oncology using chemotherapy-induced neutropenia: Example of docetaxel in non-small cell lung cancer patients.
Br J Clin Pharmacol
; 87(4): 2053-2063, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33075149
4.
Intravitreal Pharmacokinetic Study of the Antiangiogenic Glycoprotein Opticin.
Mol Pharm
; 17(7): 2390-2397, 2020 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32437164
5.
A study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months.
Paediatr Anaesth
; 29(2): 161-168, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30447167
6.
Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I-IV drugs.
J Pharmacokinet Pharmacodyn
; 46(1): 27-42, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552544
7.
Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: data from 10 phase I trials.
Br J Clin Pharmacol
; 84(1): 52-63, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28833380
8.
Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research.
J Appl Toxicol
; 38(9): 1244-1250, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29766525
9.
Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population.
Pharmacogenet Genomics
; 27(1): 27-38, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27787353
10.
What do we mean by identifiability in mixed effects models?
J Pharmacokinet Pharmacodyn
; 43(1): 111-22, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26660913
11.
Physiologically based pharmacokinetic model for 6-mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity.
Br J Clin Pharmacol
; 80(1): 86-100, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25614061
12.
Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data.
Br J Clin Pharmacol
; 79(1): 48-55, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24033787
13.
A physiologically based pharmacokinetic model for clobazam and stiripentol in adults and children.
Pharm Res
; 32(1): 144-57, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25052507
14.
Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects.
Pharm Res
; 32(5): 1764-78, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25425054
15.
Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach.
Pharm Res
; 32(6): 1864-83, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25446771
16.
Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics.
J Pharmacokinet Pharmacodyn
; 42(6): 639-57, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26231433
17.
Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations.
J Pharmacokinet Pharmacodyn
; 42(4): 349-73, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26006250
18.
Handling missing data in a duloxetine population pharmacokinetic/pharmacodynamic model - imputation methods and selection models.
Pharm Res
; 31(10): 2829-43, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24792830
19.
The use of ROC analysis for the qualitative prediction of human oral bioavailability from animal data.
Pharm Res
; 31(3): 720-30, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24072264
20.
Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.
J Pharmacokinet Pharmacodyn
; 41(2): 159-71, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24651961