Laparo-endoscopic transgastric resection of gastric submucosal tumors.

BACKGROUND: Laparoscopic and endoluminal surgical techniques have evolved and allowed improvements in the methods for treating benign and malignant gastrointestinal diseases. To date, only case reports have been reported on the application of a laparo-endoscopic approach for resecting gastric submucosal tumors (SMT). In this study, we aimed to evaluate the efficacy, safety, and oncologic outcomes of a laparo-endoscopic transgastric approach to resect tumors that would traditionally require either a laparoscopic or open surgical approach. Herein, we present the largest single institution series utilizing this technique for the resection of gastric SMT in North America. METHODS: We performed a retrospective review of a prospectively collected patient database. Patients who presented for evaluation of gastric SMT were offered this surgical procedure and informed consents were obtained for participation in the study. RESULTS: Fourteen patients were included in this study between August/2010 and January/2013. Eight (8) patients (57.1 %) were female and the median age was 56 years (range 29-78). Of the 14 cases, 8 patients (57.1 %) underwent laparo-endoscopic resection of SMTs with transgastric extraction, 5 patients (35.7 %) had conversions to traditional laparoscopic surgery, and 1 patient (7.2 %) was abandoned intraoperatively. The median operative time for this cohort was 80 min (range 35-167). Ten patients (71.4 %) had GISTs, 3 (21.4 %) had leiomyomas, and 1 (7.1 %) had schwannoma. There were no intraoperative complications. Two patients had postoperative staple line bleeding that required repeat endoscopy. The median hospital stay was 1 day (range 1-6) and there were no postoperative mortalities. At 12-month follow-up visit, only one GIST patient (10 %) had tumor recurrence. CONCLUSION: Our experience suggests that this surgical approach is safe and efficient in the resection of gastric SMT with transgastric extraction. This study found no intraoperative complications and optimal oncologic outcomes during the follow-up period. Minimally invasive surgical approaches are emerging as a valid and potentially better approach for resecting malignancies; however, continued investigation is underway to further validate this data.

Transgastric large-organ extraction: the initial human experience.

INTRODUCTION: In laparoscopy, it often is the case that port sites are enlarged for specimen extraction. This leads to higher risk of trocar site complications, such as infection or incisional hernia. Natural orifice surgery (NOTES) is beneficial for minimizing these complications, and this is emphasized when the extracted specimen is of large volume. We have been using transgastric technique for appendectomy, cholecystectomy, and laparoscopic sleeve gastrectomy (LSG). Of these transgastric operations, we focus on the one with relatively large-organ extraction: LSG with transoral remnant extraction (TORE). We describe the details and feasibility of this procedure and compare the outcomes to conventional LSG. METHODS: All patients undergoing LSG were considered candidates for TORE and were consented for this procedure if interested after an informed discussion. Eighteen LSGs with TORE (TORE group) and ten conventional LSGs (non-TORE group) were performed from August 2010 to March 2011. We retrospectively compared these two groups for the age, sex, preoperative body mass index, operating room time, hospital stay, excess weight loss (EWL), and trocar site complications. Laparoscopic sleeve gastrectomy with TORE consists of conventional LSG and transgastric retrieval of the resected stomach. The procedure exceeds exactly the same manner as conventional LSG until the initial stapling of the stomach. For TORE, the gastrectomy is initiated 5 cm proximal to the pylorus than usual LSG to save the space for the gastrotomy used for specimen retrieval. After the gastrectomy is completed, the full thickness of the distal most part of the staple line is incised open as wide as 2 cm by using electric cautery or ultrasonic dissector. A flexible upper endoscope, which has been in the stomach already as a bougie for gastrectomy, is then guided into the peritoneal cavity through the gastrotomy. The specimen is grasped endoscopically with a snare and extracted transorally. Following this, the gastrotomy is closed laparoscopically. The final shape of the gastric sleeve is identical to the one of conventional LSG. RESULTS: There was no significant difference between the TORE and the non-TORE group for patients' profile, operating room time, hospital stay, and EWL. Neither group has experienced perioperative complications. All specimens were extracted readily and safely in the TORE group. Of the ten cases in the non-TORE group, four required extension of the trocar site. No trocar site complications were found in the TORE group, whereas the extended trocar site developed panniculitis in two cases of the non-TORE group; one required panniculectomy for refractory induration. CONCLUSIONS: TORE can be safely and easily performed by surgeons with laparoscopic and endoscopic skill, and with commonly available instruments. While producing identical outcomes, our initial experience with the TORE technique demonstrates an advantage over traditional LSG, because it minimizes trocar site complications. Transgastric organ extraction is potentially applicable to other large-organ extractions in laparoscopic surgery without excessive risk or resources. Larger case volume and longer follow-up period is awaited.

Initial experience with an innovative endoscopic clipping system.

There are few options for the treatment of fistulas, leaks, and perforations endoscopically. Here we describe our experience with an endoscopic clipping system. A retrospective review of all cases using the Over-The-Scope-Clip system (Ovesco Endoscopy AG, Tuebingen, Germany) was performed. The system was utilized in ten patients with gastrointestinal surgical complications. Four patients had gastric leaks following sleeve gastrectomy, one had a post-operative colonic leak, two had gastro-gastric fistulas following gastric bypass, and three had esophageal perforations. Two leak patients had complete resolution, one had a contained leak following clip placement that was clinically insignificant, and the fourth patient had a persistent leak despite two clipping procedures. Two patients had gastro-gastric fistulas following roux-en-y gastric bypass surgery and, while they both had initial success, the fistulas recurred. One patient presented with anastomotic leak following colon resection but the system was unable to reach the treatment site. Three patients were successfully treated for esophageal perforation. There were no complications. This over-the-scope endoscopic clip system is simple to use, safe, and successful in approximating tissue to treat traditionally difficult surgical complications. Further experience and longer follow-up are needed to assess its indications as related to defect size and location.

3D Volumetry and its Correlation Between Postoperative Gastric Volume and Excess Weight Loss After Sleeve Gastrectomy.

BACKGROUND: The volume of the postoperative gastric remnant is a key factor in excess weight loss (EWL) after sleeve gastrectomy (SG). Traditional methods to estimate gastric volume (GV) after bariatric procedures are often inaccurate; usually conventional biplanar contrast studies are used. METHODS: Thirty patients who underwent SG were followed prospectively and evaluated at 6 months after the surgical procedure, performing 3D CT reconstruction and gastric volumetry, to establish its relationship with EWL. The gastric remnant was distended with effervescent sodium bicarbonate given orally. Helical CT images were acquired and reconstructed; GV was estimated with the software of the CT device. The relationship between GV and EWL was analyzed. RESULTS: The study allowed estimating the GV in all patients. A dispersion diagram showed an inverse relationship between GV and %EWL. 55.5% of patients with GV ≤ 100 ml had %EWL 25-75% and 38.8% had an %EWL above 75% and patients with GV ≥ 100 ml had an %EWL under 25% (50% of patients) or between 25 and 75% (50% of this group). The Pearson's correlation coefficient was R = 6.62, with bilateral significance (p ≤ .01). The Chi-square result correlating GV and EWL showed a significance of .005 (p ≤ .01). The 3D reconstructions showed accurately the shape and anatomic details of the gastric remnant. CONCLUSIONS: 3D volumetry CT scans accurately estimate GV after SG. A significant relationship between GV and EWL 6 months after SG was established, seeming that GV ≥ 100 ml at 6 months of SG is associated with poor EWL.

La vagina como sitio de extracción y puerto laparoscópico en NOSE y NOTES / The vagina as an extraction site and laparoscopic port in NOSE and NOTES

El objetivo del presente estudio es evaluar nuestra experiencia inicial utilizando la vagina para el retiro de especímenes quirúrgicos o como puerto laparoscópico en intervenciones de cirugía a través de orificios naturales (NOTES). Métodos: Analizamos retrospectivamente los datos de pacientes femeninos, intervenidos en el Instituto Medico La Floresta, Caracas, Venezuela, desde Junio de 2009 a junio de 2015. Dichos pacientes fueron sometidas a intervenciones involucrando resecciones laparoscópicas de órganos sólidos como pancreatectomías distales, esplenectomías y miomectomías uterinas, utilizando la vagina como sitio de extracción. También incluimos pacientes sometidas a apendicectomía transvaginal híbrida NOTES y a colecistectomía transvaginal híbrida. Reportamos el procedimiento técnico, las complicaciones relacionadas con el acceso transvaginal y el seguimiento clínico. Resultados: Cuatro pacientes fueron sometidas a pancreatectomía distal con esplenectomía, siete a esplenectomía laparoscópica, cuatro casos fueron resecciones de masas anexiales y seis miomectomías uterinas. Tres pacientes fueron intervenidas para apendicectomía laparoscópica hibrida transvaginal y cuatro a colecistectomía hibrida trans-vaginal. En todos los casos el espécimen quirúrgico fue retirado a través de la vagina. Todas las pacientes reportaron manchado vaginal mínimo por un máximo de 14 días (media de 8), sangramiento escaso durante el coito por un máximo de 54 días (media de 32) y ninguna paciente reportó dispareunia u otras molestias relacionadas con el acceso vaginal a los seis meses. Conclusiones: El uso de la vagina como sitio de extracción para especímenes quirúrgicos es posible y seguro, incluso en casos de órganos sólidos o especímenes contaminado(AU)

The objective of this study is to evaluate our initial experience, using the vagina, for the removal of surgical specimens, or as a laparoscopic port in surgical interventions through natural orifices "NOTES" or (natural orifice translumenal endoscopic surgery). Methods: We retrospectively analyzed data from female patients operated at the La Floresta Medical Institute in Caracas, Venezuela, from June 2009 to June 2015, who underwent interventions involving laparoscopic resections of solid organs, such as distal pancreatectomies, splenectomies, and uterine myomectomies. Using the vagina as an extraction site. We also included patients undergoing hybrid NOTES trans-vaginal appendectomy and hybrid trans-vaginal cholecystectomy. We report the technical procedure, complications related to trans-vaginal access and clinical follow-up. Results: Four patients underwent distal pancreatectomy with splenectomy, seven underwent laparoscopic splenectomy, four cases were resections of adnexal masses and six were uterine myomectomies. Three patients underwent surgery for trans-vaginal hybrid laparoscopic appendectomy and four for trans-vaginal hybrid cholecystectomy. In all cases, the surgical specimen was removed through the vagina. All patients reported minimal vaginal blood spotting for a maximum of 14 days (average of 8), scarce bleeding during intercourse for a maximum of 54 days (average of 32), and no patient reported dyspareunia or other discomfort related to vaginal access after six months. Conclusions: The use of the vagina as an extraction site for surgical specimens is possible and safe, even in cases of solid organs or contaminated specimens(AU)

Tumor maligno de la vaina de nervio periférico: y neurofibromatosis / Malignant tumor of the peripheral nerve shealth: and neurofibromatosis

Reportamos el caso de paciente femenina de 29 años de edad, diagnóstico de neurofibromatosis, en segundo mes de posoperatorio de resección local lesión en flanco izquierdo, biopsia reportó tumor mesenquimal maligno, presenta masa de rápido crecimiento en cicatriz quirúrgica. Examen físico: tumor en hemiabdomen izquierdo, duro, fijo, piel ulcerada. Resonancia magnética nuclear evidencia masa retroperitoneal con extensión a cavidad, pared abdominal, lobulada, desplaza grandes vasos, uréter, riñón izquierdo colon descendente. La laparotomía evidencia tumor retroperitoneal que desplaza grandes vasos, uréter, riñón, colon izquierdo, infiltra pared abdominal, piel, lobulado, encapsulado. Biopsia e inmunohistoquímica con proteína S-100 y LEU 7 son compatibles con tumor maligno de la vaina de los nervios periféricos asociado a neurofibromatosis alto grado de malignidad. La sobrevida es 15 por ciento-30 por ciento a 5 años. El tratamiento consiste en resección con biopsia intraoperatoria para comprobar negatividad de márgenes y radioterapia posoperatoria. Quimioterapia en casos de metástasis a distancia.

We report a case 29 year old female with history of neurofibromatosis and local resection of a left flank tumor. The pathology of surgical specimen reports malignant mesenchymal neoplasm. Two months after the procedure refers rapidly growing tumor located underneath the surgical scar. Physical examination: tumor in left lower quadrant of the abdomen, firm, with ulcerated skin. The magnetic nuclear resonance reveals retroperitoneal tumor extending into abdominal cavity, displacing aorta, vena cava, left kidney, left urether, descending colon. Laparotomy is performed, a retroperitoneal tumor infiltrating abdominal wall and skin, lobulated. The pathology and immunohistochemistry stains with S-100 protein and LEU 7 was compatible with peripheral malignant nerve sheath tumor associated neurofibromatosis malignant high grade neoplasia. Five year survival rates are low: 15 %-30 %. Management of these tumors includes wide local resection with intraoperative frozen section of surgical margins, postoperative external beam radiotherapy and chemotherapy for metastatic disease.

Glándulas salivares mayores: Hospital José A Vargas Instituto Venezolano de los Seguros Sociales Maracay / Mayor salivary glands; at José A Vargas Hospital Institute Venezuelan of the Social Secure Maracay

Nuestro objetivo es evaluar los resultados obtenidos en patología quirúrgica de glándulas salivales mayores en el Servicio de Cirugía General del Hospital José A. Vargas I.V.S.S. de Maracay, desde febrero 1993 a marzo de 2002. Estudio retrospectivo y descriptivo del diagnóstico, tratamiento complicaciones y seguimiento de los pacientes con patología quirúrgica de glándulas salivares mayores en un servicio de Cirugía General. Ingresaron 13 pacientes con patología de glándulas salivares mayores entre 1993-2002, 92 por ciento fueron tumores: 76 por ciento benignos, 15 por ciento malignos y una litiasis. El 85 por ciento mayores de 31 años, el 100 por ciento consultó por presencia de tumor, 69 por ciento se localizó en parótida, el diagnóstico preoperatorio: tumor benigno en 84 por ciento, un caso sospechoso por punción con aguja fina de lesión submaxilar T2N1M0 y un adenocarcinoma de parótida T4N0M0. Parotidectomía superficial y submaxilectomía se practicó en los benignos; en tumor maligno de parótida y submaxilar: parotidectomía total-resección del facial con piel; y submaxilectomía con disección modificada de cuello; biopsia intraoperatoria 92 por ciento; 69 por ciento fueron adenomas pleomórficos, 15 por ciento tumor maligno: un adenocarcinoma de células acinares y un mucoepidermoide GIII. Como complicaciones: 2 casos con paresia y uno con parálisis permanente. El 84 por ciento se controló regularmente por 4 años. La patología de glándulas salivares es poco frecuente, son más comunes los tumores benignos, el tratamiento de eleción es quirúrgico, la biopsia intraoperatoria debe considerarse para definir los márgenes de resección y disecciones ganglionares, no realizar resecciones limitadas o incompletas ya que las reoperaciones causan mayor enfermedad con menor probabilidad de curación, el seguimiento se hará en los tumores benignos y malignos, cada tres meses los dos primeros años, cada seis meses los tres años siguientes y una vez al año a partir del quinto año