Detalhe da pesquisa
1.
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Proc Natl Acad Sci U S A
; 116(27): 13320-13329, 2019 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31209056
2.
Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 22(8): 2932-7, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22421020
3.
Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists.
Bioorg Med Chem Lett
; 21(6): 1748-53, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316962
4.
Design, synthesis, and structure-activity relationships of indole-3-heterocycles as agonists of the CB1 receptor.
Bioorg Med Chem Lett
; 21(1): 506-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21075630
5.
Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate.
Bioorg Med Chem Lett
; 21(8): 2541-6, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21411321
6.
Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists.
Bioorg Med Chem Lett
; 20(16): 4918-21, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20634067
7.
Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.
Bioorg Med Chem Lett
; 20(24): 7327-30, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074434
8.
Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships.
J Med Chem
; 45(9): 1806-16, 2002 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11960492