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1.
Pediatr Cardiol ; 41(5): 1058-1066, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32367307

RESUMO

To evaluate whether avoidance of a risk factor associated with loss of pulse (LOP) following femoral artery (FA) catheterization in infants identified from previous study, was associated with decreased incidence of LOP during a prospective evaluation. Since initiation of routine ultrasound guided femoral arterial access (UGFAA) for infants undergoing catheterization in Jan 2003-Dec 2011 (Period-1), our incidence of LOP had stayed steady. Prospective evaluation between Jan 2012-Dec 2014 (Period-2), identified FA-diameter < 3 mm as risk factor for LOP. Between Jan 2015-Dec 2018 (Period-3), an initiative to avoid UGFAA for FA-diameter < 3 mm was implemented to determine whether that led to a decreased incidence of LOP. FA-diameter was measured prior to USGFAA and ratio of outer diameter of arterial sheath to luminal diameter of cannulated artery (OD/AD ratio) was calculated during Periods-2 and 3. The incidence and risk factors for LOP were assessed during the three periods. FA-access rates dropped significantly during Period-3 (56.7% vs. 93.8% and 90.4% during Periods-1 and 2, respectively, p < 0.001). Incidence of LOP in Period-3 decreased to 2.7% compared to 12.5% (Period-1) and 17.4% (Period-2) (p < 0.001). By multivariate analysis, FA size < 3 mm and an OD/AD ratio > 40% were the only significant independent predictors for LOP (OR 6.48, 95% CI 2.3-11.42, p < 0.001 and OR 4.16, 95% CI 1.79-8.65, p < 0.01, respectively). Access of femoral artery < 3 mm and OD/AD ratio > 50% are associated with increased incidence of LOP. Avoidance of these factors may help decrease complications in infants undergoing cardiac catheterizations.


Assuntos
Cateterismo Cardíaco/métodos , Artéria Femoral/patologia , Pressão Arterial , Cateterismo Cardíaco/efeitos adversos , Feminino , Artéria Femoral/diagnóstico por imagem , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Estudos Prospectivos , Pulso Arterial , Fatores de Risco , Ultrassonografia de Intervenção/métodos
2.
Pediatr Cardiol ; 41(6): 1135-1144, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32363434

RESUMO

The objectives of this study were to construct femoral artery (FA) and femoral vein (FV) nomograms in children aged 0-4 years and to construct probability curves for the occurrence of arterial access complications based on the size of the FA. The FV and FA are commonly accessed during cardiac catheterizations in children with congenital heart diseases (CHD). However, nomograms for vessel dimensions based on child's age or size are not available. This knowledge may be helpful for interventional planning. A prospective study was performed on 400 children (age 0-4 years) with CHD undergoing cardiac catheterizations over a 3-year period. Ultrasound evaluation of the right and left FA and FV was performed under anesthesia prior to vascular access. Regression modeling was applied to derive nomograms based on quantile polynomial regression, which yielded good fit to the data judged by R-squared. GAMLSS transformation method was used to formulate smoothed percentiles. A separate prospective evaluation of FA to determine the size below which loss of pulse (LOP) are likely to occur was performed. Nomograms for FA and FV diameter and cross-sectional area against age and body surface area and probability curves for FA LOP were constructed. It is now possible to examine ultrasound-based normal sizes of femoral vein and artery in children 0-4 years of age. Femoral vessel nomograms and LOP probability curves may help with interventional planning. Future studies with larger sample size, including children of other ages may be useful.


Assuntos
Artéria Femoral/diagnóstico por imagem , Nomogramas , Cateterismo Cardíaco/métodos , Pré-Escolar , Feminino , Artéria Femoral/patologia , Cardiopatias Congênitas/cirurgia , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Prospectivos , Ultrassonografia
3.
Catheter Cardiovasc Interv ; 90(4): 618-625, 2017 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-28707365

RESUMO

OBJECTIVE: To compare image quality, radiation and contrast doses required to obtain 3D-Digital subtraction rotational angiography (3D-DSRA) with 3D-Digital rotational angiography (3D-DRA) in infants (children ≤ 2 years of age) and adults with congenital heart diseases (ACHD). BACKGROUND: 3D-DRA can be performed with radiation doses comparable to bi-plane cine-angiography. However, 3D-DRA in infants requires a large contrast volume. The resolution of 3D-DRA performed in ACHD patients is limited by their soft tissue density. We hypothesized that the use of 3D-DSRA could help alleviate these concerns. METHODS: Radiation (DAP) and contrast doses required to obtain 3D-DSRA was compared with 3D-DRA in 15 age-, size-, and intervention-matched infants and 15 ACHD patients. The diagnostic quality and utility of these two modalities were scored by 4 qualified independent observers. RESULTS: Both in infants and adults, the median contrast volume for 3D-DSRA was lower than 3D-DRA (0.98 vs. 1.81 mL/kg; P < 0.001 and 0.92 vs. 1.4 mL/kg; P < 0.001, respectively) with an increased DAP (median: 188 vs. 128 cGy cm2 ; P = 0.068 and 659 vs. 427 cGy cm2 ; P = 0.045, respectively). The diagnostic quality and utility scores for rotational-angiography, and 3D-reconstruction were superior for 3D-DSRA (score = 94 vs. 80%, P = 0.03 and 90 vs.79%, P = 0.01, respectively) and equivalent for multi-planar-reformation and 3D-roadmapping in ACHD patients compared with 3D-DRA. All scores for both modalities were equivalent for infants. CONCLUSIONS: 3D-DSRA can be acquired using lower contrast volume with a mildly higher radiation dose than 3D-DRA in infants and ACHD patients. The diagnostic quality and utility scores for 3D-DSRA were higher in ACHD patients and equivalent for infants compared with 3D-DRA.


Assuntos
Angiografia Digital , Cateterismo Cardíaco , Angiografia Coronária/métodos , Vasos Coronários/diagnóstico por imagem , Cardiopatias Congênitas/diagnóstico por imagem , Imageamento Tridimensional , Interpretação de Imagem Radiográfica Assistida por Computador , Fatores Etários , Pré-Escolar , Meios de Contraste/administração & dosagem , Feminino , Humanos , Lactente , Masculino , Variações Dependentes do Observador , Valor Preditivo dos Testes , Doses de Radiação , Exposição à Radiação , Reprodutibilidade dos Testes , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
4.
Catheter Cardiovasc Interv ; 89(4): 709-716, 2017 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-27888578

RESUMO

OBJECTIVES: The aim of this study was to evaluate the effectiveness of UltraBLOX™ radiation attenuating hand cream during lengthy cardiac catheterization procedures in children. BACKGROUND: The hands of interventional cardiologists receive high doses of radiation due to their proximity to the X-ray beam. Radiation attenuating gloves have about a 26% attenuation rate, but reduce dexterity and tactile sensation. The UltraBLOX™ cream is a new FDA-approved X-ray attenuating cream that can be applied to the operator's hands for radio-protection. METHODS: Two nanoDot™ dosimeters were secured side by side on the dorsum of the operator's (n = 2) left hand close to the wrist. One dosimeter and the rest of the hand were covered with 0.2 mm layer of the cream. The other dosimeter was unshielded. Procedures were performed using 110 kVp fluoroscopy at 15 pulses/sec. The measurements were categorized into four groups dependent on the duration of the procedure. The patients in all four groups were well matched for age and size. RESULTS: Procedural and cumulative hand radiation doses were higher with longer procedural duration. The overall % attenuation by the cream was 39.7% (28.6-51.5) and was unaffected by the length of the procedure (median: 40.9% at 30 min and 41.4% at 180 min; P = 0.66) or the dose of radiation. The kappa statistic for interobserver agreement for good tactile sensitivity was 0.82. CONCLUSIONS: UltraBLOX™ cream provides a new option for radio-protection for the hands of interventional cardiologists without impairing tactile sensitivity. There was no decrease in attenuation up to 180 min. © 2016 Wiley Periodicals, Inc.


Assuntos
Cateterismo Cardíaco/métodos , Cardiologistas , Fluoroscopia/efeitos adversos , Lesões por Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Radiografia Intervencionista/efeitos adversos , Creme para a Pele , Adolescente , Criança , Pré-Escolar , Feminino , Seguimentos , Mãos/efeitos da radiação , Humanos , Lactente , Masculino , Exposição Ocupacional/prevenção & controle , Estudos Prospectivos , Doses de Radiação
5.
Catheter Cardiovasc Interv ; 87(2): 310-7, 2016 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-26525611

RESUMO

OBJECTIVES: The aim of this study was to describe and differentiate the morphology of patent ductus arteriosus (PDA) seen in children born prematurely from other PDA types. BACKGROUND: PDAs are currently classified as types A-E using the Krichenko's classification. Children born prematurely with a PDA morphology that did not fit this classification were described as Type F PDA. METHODS: A review of 100 consecutive children who underwent transcatheter device closure of PDA was performed. The diameter and length (L) of the PDA and the device diameter (D) were indexed to the descending aorta (DA) diameter. RESULTS: Comparison of 26 Type F PDAs was performed against, 29 Type A, 7 Type C and 32 Type E PDAs. Children with Type F PDAs (median 27.5 weeks gestation) were younger during the device occlusion compared with types A, C, and E (median age: 6 vs. 32, 11, and 42 months; P = 0.002). Type F PDAs were longer and larger, requiring a relatively large device for occlusion than types A, C, and E (Mean L/DA: 1.88 vs. 0.9, 1.21, and 0.89, P ≤ 0.01 and Mean D/DA: 1.04 vs. 0.46, 0.87, and 0.34, P ≤0.01). The Amplatzer vascular plug-II (AVP-II) was preferred for occlusion of Type F PDAs (85%; P <0.001). CONCLUSIONS: Children born prematurely have relatively larger and longer PDAs. These "fetal type PDAs" are best classified separately. We propose to classify them as Type F PDAs to add to types A-E currently in use. The AVP-II was effective in occluding Type F PDAs.


Assuntos
Aortografia , Cateterismo Cardíaco/instrumentação , Permeabilidade do Canal Arterial/diagnóstico , Canal Arterial/diagnóstico por imagem , Ecocardiografia Doppler em Cores , Recém-Nascido Prematuro , Dispositivo para Oclusão Septal , Criança , Pré-Escolar , Canal Arterial/anormalidades , Permeabilidade do Canal Arterial/classificação , Permeabilidade do Canal Arterial/terapia , Feminino , Idade Gestacional , Humanos , Lactente , Recém-Nascido , Masculino , Seleção de Pacientes , Valor Preditivo dos Testes , Desenho de Prótese , Estudos Retrospectivos , Terminologia como Assunto , Resultado do Tratamento
6.
Catheter Cardiovasc Interv ; 88(7): 1098-1107, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27535615

RESUMO

OBJECTIVES: The objectives of this study were to describe the prevalence, mechanisms, and identify risk factors for acute loss of arterial pulse (LOP) in children who had ultrasound-guided femoral arterial access (UGFAA) during cardiac catheterization. BACKGROUND: LOP is a known complication in children following femoral arterial (FA) access for cardiac catheterization. The prevalence of LOP requiring treatment ranges between 4% and 8%. METHODS: A prospective study was performed including 486 cardiac catheterizations using UGFAA in children ≤18 years over a 3 years period. Ultrasound and Doppler evaluations were performed prior to and at the end of the procedure. RESULTS: LOP was identified in 33 cases (6.8%) with 23 (4.7%) requiring treatment. For children ≤6 months, the prevalence of LOP requiring treatment was 13.6%. FA diameter <3 mm was the only significant independent predictor for LOP (OR: 8.44, 95% CI: 2.07-34.5, P < 0.001). Smaller patient size, number of access attempts, time required for access, operator experience, sheath size, and length of procedure were not found to be significant predictors. Children with LOP had a greater percentage decrease in vessel diameter (median 62% vs 18%, P < 0.001) compared to those without LOP. FA thrombus was diagnosed only in 9 patients (27% of those with LOP). CONCLUSIONS: The prevalence of LOP requiring treatment is 4.7% when UGFAA is used during pediatric cardiac catheterizations. Arterial spasm was more common than thrombus as a cause of LOP. FA diameter <3 mm was the only independent predictor for LOP in this carefully designed prospective study. © 2016 Wiley Periodicals, Inc.


Assuntos
Arteriopatias Oclusivas/epidemiologia , Cateterismo Cardíaco/efeitos adversos , Cateterismo Periférico/efeitos adversos , Artéria Femoral/diagnóstico por imagem , Pulso Arterial , Trombose/epidemiologia , Ultrassonografia Doppler , Ultrassonografia de Intervenção , Adolescente , Fatores Etários , Arteriopatias Oclusivas/diagnóstico por imagem , Arteriopatias Oclusivas/fisiopatologia , Arteriopatias Oclusivas/terapia , Cateterismo Cardíaco/métodos , Cateterismo Periférico/métodos , Criança , Pré-Escolar , Feminino , Artéria Femoral/fisiopatologia , Humanos , Lactente , Masculino , Prevalência , Estudos Prospectivos , Punções , Medição de Risco , Fatores de Risco , Tennessee/epidemiologia , Trombose/diagnóstico por imagem , Trombose/fisiopatologia , Trombose/terapia , Resultado do Tratamento , Vasoconstrição
7.
Asian J Transfus Sci ; 13(1): 30-33, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31360007

RESUMO

BACKGROUND: Antigen "N" is a high-frequency antigen of the MNS blood groups and carried on glycophorin B that is resistant to enzymatic cleavage by trypsin, and provides differential diagnosis of its antibody specificity to N being present of glycophorin A. Naturally occurring IgM antibodies to N are known to be clinically insignificant, as against the IgG counterpart with clinical relevance. AIM: Auto-anti-"N" association with the bladder cancer was explored for its clinical significance as well as its interference in grouping anomaly. MATERIALS AND METHODS: A warm environment was created while blood sampling for the laboratory work up as the patient had a high-titer auto-cold agglutinin causing spontaneous hemagglutination. The antibody was tested by standard serological methods with the red cell, antisera, and enzymes prepared in house or obtained commercially. RESULTS: The case was admitted to hospital with high fever and hematuria; he was diagnosed with malaria and bladder cancer. He required transfusions in the face of severe anemia. His blood sample posed problems in compatibility tests due to autoantibody present. Serological workup revealed its specificity as anti-"N." CONCLUSION: Auto-anti-"N" as a cause of severe anemia could not be attributed to, for concurrent malarial infection. However, its presence may have some association with the underlying malignant condition.

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