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An Acad Bras Cienc ; 96(1): e20230791, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38656058

RESUMO

Although control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and outcomes between patients with active tuberculosis infection and matched controls. This is a matched case-control study based on data from the Brazilian Covid-19 Registry, in hospitalized patients aged 18 or over with laboratory confirmed Covid-19 from March 1, 2020, to March 31, 2022. Cases were patients with tuberculosis and controls were Covid-19 patients without tuberculosis. From 13,636 Covid-19, 36 also had active tuberculosis (0.0026%). Pulmonary fibrosis (5.6% vs 0.0%), illicit drug abuse (30.6% vs 3.0%), alcoholism (33.3% vs 11.9%) and smoking (50.0% vs 9.7%) were more common among patients with tuberculosis. They also had a higher frequency of nausea and vomiting (25.0% vs 10.4%). There were no significant differences in in-hospital mortality, mechanical ventilation, need for dialysis and ICU stay. Patients with TB infection presented a higher frequency of pulmonary fibrosis, abuse of illicit drugs, alcoholism, current smoking, symptoms of nausea and vomiting. The outcomes were similar between them.


Assuntos
COVID-19 , Coinfecção , Hospitalização , SARS-CoV-2 , Humanos , COVID-19/complicações , Masculino , Brasil/epidemiologia , Estudos de Casos e Controles , Feminino , Pessoa de Meia-Idade , Coinfecção/epidemiologia , Hospitalização/estatística & dados numéricos , Adulto , Sistema de Registros , Tuberculose/complicações , Tuberculose/epidemiologia , Mortalidade Hospitalar , Pandemias , Idoso , Pneumonia Viral/complicações , Pneumonia Viral/epidemiologia , Betacoronavirus , Infecções por Coronavirus/complicações , Infecções por Coronavirus/epidemiologia
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