Vibrio albensis bacteremia: A case report and systematic review.

Vibrio species are gram-negative rods usually known to cause gastroenteritis and infrequently extraintestinal infections in humans. V. cholerae are classically associated with cholera epidemics, particularly serogroup O1 and serogroup O139. However, Vibrio albensis, a non-O1/ non-O-139 serogroup is rarely implicated in human infections. Thus, there is a paucity of data available on the pathogenic profile of V. albensis infections in humans and more research is needed to further delineate the clinical course and management. To fill this gap in the literature, we present the successful management of V. albensis bacteremia in a 64-year-old patient, and we conducted a systematic review of V. albensis infections reported to date, aiming to explore the clinical presentation, course, and management of V. albensis infections.

Chronic myelogenous leukemia presenting with Morel Lavallée lesion: A case report of a rare presentation.

Chronic myelogenous leukemia is a myeloproliferative neoplasm characterized by the BCR-ABL1 fusion gene and the development of the Philadelphia chromosome, which leads to an increase in granulocytes and bone marrow myeloid precursors in the blood, it can lead to many possible complications depending on the disease stage at the time of diagnosis. The Morel-Lavallée lesion (MLL) is a closed traumatic soft-tissue degloving injury, that results from the separation of the hypodermis from the underlying fascia, with resultant hemo-lymphatic fluid collection between the tissue layers. We report a case of a 48-year-old male patient, with no chronic illnesses, who presented with 2 weeks history of posterior chest wall pain and swelling. Initial investigation showed a white blood cell count of 364.4 × 103/µl. Bone marrow pathology report findings were consistent with chronic myeloid leukemia (CML), and the BCR-ABL test came positive. CT chest with contrast showed a large chest wall lesion, suggestive of a Morel-Lavallee lesion. Ultrasound-guided aspiration of the lesion yielded 20 mm of fluid from the thick hematoma. Histopathology of the fluid showed Necrotic debris with mixed inflammation. Patient's condition improved, and he was discharged on Dasatinib with follow-up in hematology and surgery clinics.

The prevalence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in brucellosis patients: Systematic review and meta-analysis.

BACKGROUND: Hyponatremia is a prevalent electrolyte abnormality amongst hospitalized patients. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatremia. Minimal literature described an association between SIADH and brucellosis. This paper aimed to systematically review the literature to synthesize the prevalence of SIADH in brucellosis patients. METHODS: We comprehensively searched PubMed, EMBASE, and Google scholar for observational studies examining the prevalence of SIADH in brucellosis patients. There were no age, language, or date limitations. We used a prevalence meta-analysis using the random-effects model with double arcsine and back transformation. I squared (I2) was used to determine heterogeneity. The MetaXl software was used for statistical analysis. RESULTS: Three observational studies met our inclusion criteria. The reported prevalence of SIADH in the constituent studies ranged from 3 to 56%. The quantitative synthesis, encompassing 306 patients' data, revealed a pooled SIADH prevalence of 20% (95% CI 0.00-52%, I2 96%). The quality assessment revealed a moderate quality of included studies. The results were heterogeneous, as depicted by a high I2. DISCUSSION AND CONCLUSION: The results from this review revealed a relatively high prevalence of SIADH of 20% in patients with brucellosis. Thus, hyponatremia in patients with chronic fever should prompt SIADH and brucellosis workup, particularly in endemic brucellosis areas. Likewise, patients with brucellosis merit hyponatremia screening. More extensive studies are needed to ascertain the exact prevalence of hyponatremia and SIADH in this patient cohort and their impact on the diagnosis and the overall prognosis.

Rhino-orbital Mucormycosis as a complication of severe COVID-19 pneumonia.

Mucormycosis has multiple clinical phenotypes, which are more common in immunocompromised patients, especially those with diabetes mellitus. Debilitating rhino-orbital-cerebral and pulmonary infections by far represent the most typical clinical phenotypes associated with these fungi. Mucormycosis is an uncommon infection; however, there have been isolated sporadic tiny outbreaks around the world. With the substantial increase in COVID-19 cases in India, there is a parallel increase in the number of cases of Mucormycosis. A few reports raising unusual concomitant mucormycosis in COVID-19 patients have raised a possible association between the two diseases. We report a 59-year-old male with an established history of uncontrolled diabetes mellitus admitted to the hospital with severe COVID-19 pneumonia (severity ascertained according to WHO classification) treated with steroids and discharged home following full recovery. However, one week later, he presented with right eye ophthalmoplegia and complete loss of vision, which was subsequently established as orbital Mucormycosis. This case highlights the need for heightened awareness of this atypical secondary infection (especially systemic mycosis) in patients recovering from COVID-19 infection.

Thyrotoxicosis Presenting With Acute Cholecystitis: A Case Report and Literature Review.

Hyperthyroidism primarily presents with the symptoms and signs of thyrotoxicosis. However, many cases might present with a precipitating factor that unmasks the hyperthyroid status of the patients. These factors are associated with a stress condition, with infections being the most common factors, diabetic ketoacidosis, acute coronary syndrome, and pulmonary embolism. We present a case of hyperthyroidism masqueraded as acalculous cholecystitis.

Case Report: COVID-19 Masquerading as an Acute Surgical Abdomen.

SARS-CoV-2 infection can present with various clinical features, among which gastrointestinal manifestations such as nausea, diarrhea, vomiting, and mild abdominal pain have been reported. Recognition of rare presentations of SARS-CoV-2 infection has increased over time. These atypical and rare presentations may lead to difficulties in establishing the diagnosis in a timely manner; furthermore, they may lead to unnecessary investigations, extended hospital stays, adverse outcomes, and more strain on healthcare resources. We present three cases admitted to our hospital with a picture that mimicked an acute abdomen, necessitating surgical assessment and evaluation. All cases turned out to be SARS-CoV-2 positive and did not require surgical management. We discuss the management course, highlight the importance of abdominal symptoms in the setting of COVID-19, and discuss the implications of this association for medical practice amid the current pandemic in both resource-rich and resource-limited settings.

Case Report: COVID-19-Related Pneumothorax-Case Series Highlighting a Significant Complication.

COVID-19 is a recent outbreak in China and rapidly spread worldwide. Lung consolidation is the most common radiologic finding of COVID-19 pneumonia. Pneumothorax has been rarely reported as a complication of severe COVID-19 pneumonia. Early recognition and management are detrimental to the outcome. We here report three cases of SARS-CoV-2 infection complicated by pneumothorax. In addition, we present a brief literature review.