Detalhe da pesquisa
1.
Lipid metabolism in astrocytic structure and function.
Semin Cell Dev Biol
; 112: 123-136, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32773177
2.
C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.
Brain
; 142(12): 3771-3790, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647549
3.
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.
Brain
; 142(3): 586-605, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30698736
4.
Peripheral Glycolysis in Neurodegenerative Diseases.
Int J Mol Sci
; 21(23)2020 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33255513
5.
Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response.
Int J Mol Sci
; 21(21)2020 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33126586
6.
Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions.
Neuropathol Appl Neurobiol
; 41(2): 201-26, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24750211
7.
From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis.
Int Rev Neurobiol
; 176: 209-268, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38802176
8.
Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.
Brain Pathol
; 33(1): e13104, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35871544
9.
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Front Aging Neurosci
; 15: 1151848, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37251807
10.
Adenosine deaminase, not immune to a mechanistic rethink in central nervous system disorders?
Histol Histopathol
; 37(3): 189-212, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34881804
11.
Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis.
Brain Commun
; 4(2): fcac069, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35441136
12.
Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts.
Neurobiol Aging
; 105: 64-77, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34044197
13.
Why TDP-43? Why Not? Mechanisms of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis.
Neurosci Insights
; 15: 2633105520957302, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32995749
14.
A High-throughput and Pathophysiologically Relevant Astrocyte-motor Neuron Co-culture Assay for Amyotrophic Lateral Sclerosis Therapeutic Discovery.
Bio Protoc
; 9(17)2019 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31579294
15.
Understanding metabolic flexibility: a potential key to unlocking metabolic therapies in amyotrophic lateral sclerosis?
Neural Regen Res
; 15(9): 1654-1655, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32209766
16.
Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients.
Neurobiol Aging
; 36(10): 2893-903, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26344876
17.
Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis.
Neurobiol Aging
; 35(6): 1499-509, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24439480
18.
The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.
PLoS One
; 8(6): e68256, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23840839
19.
S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.
Free Radic Biol Med
; 61: 438-52, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23608463