RESUMO
BACKGROUND: Psoriasis, a chronic autoimmune condition, imposes significant burdens on patients' well-being. While corticosteroid medications are commonly used, their prolonged use presents risks. Statins, known for their immunoregulatory and anti-inflammatory properties, have emerged as potential alternatives. Previous reviews indicated that statins might improve psoriasis symptoms but showed inconsistent results and lacked meta-analyses that generated pooled effect estimates. Therefore, this study addresses this gap by providing a comprehensive overview of the impact of statins on psoriasis severity and quality of life (QoL) for patients with psoriasis. METHODS: A thorough search of four electronic databases (PubMed, Cochrane Central Register of Controlled Trials, Scopus, and Science Direct) was conducted for relevant studies published before April 2024. RESULTS: Seven studies involving 369 patients were included. This meta-analysis showed a statistically significant reduction in PASI scores at week 8 with statin treatment (MD = -1.96, 95% CI [-3.14, -0.77], p = 0.001). However, no statistically significant difference was found between statins and placebo at week 12 (MD = 0.19, 95% CI [-0.18, 0.55]). Additionally, DLQI scores indicated a significant improvement in quality of life with statins compared to placebo (MD = -3.16, 95% CI [-5.55, -0.77]). CONCLUSIONS: Statins can improve disease severity and quality of life in psoriasis patients, suggesting the potential benefits of statin therapy. However, further research is needed to determine the optimal treatment duration, address outcome heterogeneity, and explore additional benefits such as cholesterol and triglyceride reduction.
RESUMO
BACKGROUND: Nomophobia, or no mobile phone phobia, is a term used to describe psychological conditions when people fear being without a mobile phone. OBJECTIVES: This study aimed to measure the prevalence of nomophobia, its associated factors, and its impact on the academic performance of medical undergraduates at Umm Al-Qura University (UQU), Makkah City, Saudi Arabia. METHODS: A descriptive cross-sectional study included a simple random sample of 595 medical undergraduates. The study administered the Nomophobia Questionnaire, which had been validated in previous articles, using an interview-based model. The collected data were reviewed and entered into the IBM SPSS Statistics for Windows, Version 26 (Released 2019; IBM Corp., Armonk, New York) for analysis. RESULTS: A total of 595 medical students were included in this study. Most of them (99%, n = 589) had different degrees of nomophobia, while only a small percentage (1%, n = 6) did not exhibit it. The younger medical students (18-19 years old) showed significantly higher percentages of moderate to severe nomophobia in comparison to older students (P = 0.028), while there was no significant relationship between nomophobia and academic performance, despite the fact that 128 (77.1%) of students with severe nomophobia had grade point averages (GPAs) of 3.5-4.0, compared to 244 (69.1%) of students with moderate nomophobia (P = 0.150). CONCLUSIONS: This study concludes that the prevalence rate of nomophobia is generally high among medical undergraduates at UQU in Makkah City, Saudi Arabia. This disorder was detected more among younger medical undergraduates, with no significant effects on their academic performance. It is mandatory to conduct more studies with larger sample sizes of different university students (medical and non-medical) to identify factors that lead to the development of nomophobia. Qualitative research among groups of university students will add more deep information about this disorder. Health education programs should be designed and targeted at university students, focusing on the harmful health effects of excessive use of mobile phones and measures to prevent this disorder.